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Published on: 2/25/2026
Valsartan is generally safe and effective for most people, but side effects can happen, often from a drop in blood pressure or changes in kidney function and potassium; there are several factors to consider, and key details are outlined below.
Do not stop it suddenly if you feel off; know which symptoms need urgent care, who should avoid it, what labs to check, how dosing or switching may help, and recall information explained below.
If you've been prescribed valsartan, you may be wondering: Is valsartan safe? And if you're noticing new symptoms, you might also be asking: Why is my body reacting this way?
These are reasonable questions. Valsartan is a widely used and well‑studied medication, but like all prescription drugs, it can cause side effects in some people. Understanding what's normal, what's not, and what to do next can help you stay informed and confident about your treatment.
Valsartan belongs to a group of medications called angiotensin II receptor blockers (ARBs). It's commonly prescribed to:
It works by relaxing blood vessels, allowing blood to flow more easily. This lowers blood pressure and reduces strain on the heart.
For most people, valsartan is considered safe and effective when taken as prescribed.
Clinical trials and years of real‑world use show that valsartan is generally safe and well tolerated. Major medical guidelines recommend ARBs like valsartan as first‑line treatment for high blood pressure and heart failure.
However, "safe" does not mean "side‑effect free."
Like any medication, valsartan can cause reactions — some mild and temporary, others more serious. The key is understanding what your body may be telling you.
Most side effects are mild and often improve as your body adjusts.
These symptoms usually happen because valsartan lowers blood pressure. If your pressure drops quickly, you may feel temporarily unsteady.
Tip: Stand up slowly from sitting or lying down to reduce dizziness.
If you're experiencing symptoms after starting valsartan, here are some possible reasons:
When treatment begins, your body may need time to adjust to lower blood pressure. This can cause:
Your doctor may adjust your dose if symptoms persist.
Valsartan affects the renin-angiotensin system, which plays a role in kidney function. In some people — especially those with pre‑existing kidney disease — this can cause:
Doctors typically monitor kidney function and potassium levels through blood tests.
Valsartan can increase potassium in the blood (hyperkalemia), especially if you:
High potassium can cause:
This is why periodic blood tests are important.
Some people report:
While these are not the most common valsartan side effects, they can happen. If you're experiencing persistent heartburn or acid reflux symptoms, you can check if your symptoms align with GERD using a free AI-powered symptom checker to help determine if you should discuss acid reflux with your doctor.
Although uncommon, some reactions require urgent medical attention.
These are rare, but they can be serious.
You may have heard about past recalls of certain valsartan products due to contamination concerns. Between 2018 and 2020, some manufacturers recalled batches because of impurities detected during production.
Important points:
If you're concerned, you can ask your pharmacist which manufacturer supplies your medication.
Valsartan may not be appropriate if you:
Always inform your doctor about:
If your body is reacting in a way that concerns you, do not stop valsartan suddenly without medical advice — especially if you're taking it for heart failure or after a heart attack.
Sometimes the solution is simple:
There are many blood pressure medication options. If valsartan isn't the right fit for you, your doctor can help find one that is.
You should speak to a doctor right away if you experience:
These symptoms can be life‑threatening and require urgent medical attention.
For the majority of patients, valsartan is safe, effective, and well tolerated. It has been extensively studied and is recommended by major cardiology guidelines worldwide.
However:
If your body feels "off" after starting valsartan, that doesn't necessarily mean something dangerous is happening — but it does mean you should pay attention.
If you're currently taking valsartan:
Most concerns can be addressed quickly with proper medical guidance.
Medication decisions are never one‑size‑fits‑all. Valsartan has helped millions of people lower blood pressure and protect their hearts. But if you feel something isn't right, trust that instinct and have the conversation.
If you are experiencing new, severe, or potentially life‑threatening symptoms, seek medical care immediately. Otherwise, schedule time to speak to a doctor to review your symptoms and treatment plan.
Your health is a partnership — and asking questions is always the right next step.
(References)
* Schelleman H, Wirtz HS, Albin J. Management of Patients Taking Valsartan-Containing Medications Affected by Recalls Due to Nitrosamine Impurities. Am J Health Syst Pharm. 2019 Apr 15;76(8):537-542. doi: 10.1093/ajhp/zxz040. PMID: 30870313.
* Sun Y, Li C, Zhang S, Guo X. Valsartan and the Risk of Cancer: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Am J Med. 2019 Nov;132(11):1321-1329.e1. doi: 10.1016/j.amjmed.2019.07.009. PMID: 31390457.
* Alshammari TM, Alshammari F, Alrabiah Z, Alenzi A, Alkhamees O, Aleanizy FS, Alsaleh FM. Adverse drug reactions to valsartan: a disproportionality analysis of a global pharmacovigilance database. J Clin Pharm Ther. 2020 Feb;45(1):159-166. doi: 10.1111/jcpt.13054. Epub 2019 Nov 7. PMID: 31697275.
* Klonoff DC, Bressler P, Vella V, Vella A, Goldstein S, Goldfine AB. N-Nitrosodimethylamine and N-Nitrosodiethylamine in Valsartan-Containing Medications: A Review of Regulatory Actions and Patient Implications. J Am Pharm Assoc (2003). 2019 May - Jun;59(3):364-370. doi: 10.1016/j.japh.2019.03.003. PMID: 31057416.
* Vettorazzi A, Gini M, García-Rodríguez S, de la Calle A, Galán-Arriero I. Overview of Nitrosamine Impurities in Valsartan and Other Sartan Drugs. Toxics. 2022 Jan 12;10(1):31. doi: 10.3390/toxics10010031. PMID: 35055272; PMCID: PMC8781600.
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