What environmental factors can trigger restless leg syndrome?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Restless leg syndrome (RLS) is a neurological condition that causes an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations. Common triggers include inflammation, iron deficiency, pregnancy, kidney disease, and certain medications, though researchers are still working to fully understand why RLS develops in some people and not others.

Because RLS symptoms can overlap with other conditions—and because early identification of underlying causes often leads to better outcomes—it's worth taking a few minutes to evaluate your symptoms carefully. A free, instant, online symptom check can help you clarify what you're experiencing, understand possible causes, and determine the most appropriate next steps for care.

Reviewed for medical accuracy: 07/14/2026

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Explanation

Restless leg syndrome (RLS) is a condition that makes you feel like you have to move your legs. According to the research, certain factors might trigger or worsen RLS.

Inflammation: Some studies suggest that inflammation in the body might play a role in causing or worsening RLS. This means that when your body is fighting something, like an infection, it could make your legs feel more uncomfortable.
Medical Conditions: Conditions like kidney issues or having low iron levels in your blood might also make RLS worse. These conditions can affect how your body works and might lead to more leg movements.
Other Factors: There are also other things that could affect RLS, but scientists are still learning about them. More research is needed to understand exactly what causes RLS and how to help people who have it.

If you have concerns about your health, it's always a good idea to talk to a healthcare professional. You can start by using a free symptom checker to better understand what might be causing your discomfort.

(References)

Gamaldo CE, Benbrook AR, Allen RP, Scott JA, Henning WA, & Earley CJ. (2007). Childhood and adult factors associated with restless legs .... Sleep medicine, 17512781.
Weinstock LB, Walters AS, & Paueksakon P. (2012). Restless legs syndrome--theoretical roles of inflammatory .... Sleep medicine reviews, 22258033.
Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, & Winkelmann J. (2018). Comorbidities, treatment, and pathophysiology in restless .... The Lancet. Neurology, 30244828.

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