Published on: 8/19/2025
How does YCT-529 block sperm production?
YCT-529 blocks sperm production by interfering with retinoic acid signaling, which is crucial for making sperm.
What brings you in today?
Explanation
YCT-529 is a compound that affects how sperm is made by targeting something called retinoic acid signaling. Retinoic acid is important because it helps sperm develop properly.
How YCT-529 Works
- Retinoic Acid Role: Retinoic acid is like a signal that tells the body to make sperm. It works through special proteins called receptors.
- Blocking the Signal: YCT-529 stops this signal by blocking these receptors. When the signal is blocked, the body can't make sperm as it usually does.
Why It Matters
- Contraception: By stopping sperm production, YCT-529 could be used as a way to prevent pregnancies.
- Research: Scientists are studying how safe and effective this method is for use as a male contraceptive.
This approach is promising because it targets a specific part of sperm production, which might mean fewer side effects compared to other methods.
(References)
- Zhao Y, Deng S, Li C, Cao J, Wu A, Chen M, et al. (2024). The Role of Retinoic Acid in Spermatogenesis and Its .... Cells, 11240464.
- Esposito M, Amory JK, & Kang Y. (2024). The pathogenic role of retinoid nuclear receptor signaling .... The Journal of Experimental Medicine, 11318670.
- Noman MA, Kyzer JL, Chung SS, Wolgemuth DJ, & Georg GI. (2020). Retinoic acid receptor antagonists for male contraception. Biology of Reproduction, 7401398.
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