Anosacral Cutaneous Amyloidosis Quiz

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Learn more about Anosacral cutaneous amyloidosis

Content updated on Sep 20, 2022

What is anosacral cutaneous amyloidosis?

Anosacral cutaneous amyloidosis is a rare condition affecting the skin of the anus to sacral region (bottom of the spine). It arises due to abnormal protein deposition in the skin. The exact cause is unclear. It is more common among Asians.

Symptoms of anosacral cutaneous amyloidosis

  • Black/blue/brown spots or moles, on the skin and lining of the mouth

  • Scaly skin that flakes off

  • Skin hardening

Questions your doctor may ask to check for anosacral cutaneous amyloidosis

Your doctor may ask these questions to diagnose anosacral cutaneous amyloidosis

  • Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)

  • Do you have scaly skin that flakes off?

  • Do you have hardening of the skin?

Treatment for anosacral cutaneous amyloidosis

There is no single standardized effective treatment. Different therapies, including medicated creams/ ointments, phototherapy, oral medication and laser therapy are utilised.

View the symptoms of Anosacral cutaneous amyloidosis


  • Wang WJ, Huang CY, Chang YT, Wong CK. Anosacral cutaneous amyloidosis: a study of 10 Chinese cases. Br J Dermatol. 2000 Dec;143(6):1266-9. doi: 10.1046/j.1365-2133.2000.03899.x. PMID: 11122031.

Medically Reviewed By:

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Yukiko Ueda, MD


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