Overview
Diverticulitis and ulcerative colitis both affect the colon but are fundamentally different conditions. Diverticulitis is an acute inflammation or infection of small pouches (diverticula) that can form in the colon wall, typically due to blockage or infection. Ulcerative colitis is a chronic autoimmune condition that causes continuous inflammation and ulcers in the inner lining of the colon. While both can cause abdominal pain and changes in bowel habits, ulcerative colitis is long-term and often involves ongoing treatment to control flares.
Disease Summaries
Diverticulitis: Diverticular disease is a group of conditions in which tiny pouches (diverticula) form in the colon. These pouches bulge out through weak spots in your colon. The pouches can become inflamed (red, swollen) or infected. When the pouches are infected, the condition is called diverticulitis. Risk factors include chronic constipation, aging, obesity and a sedentary lifestyle.
Ulcerative Colitis: Ulcerative Colitis is an inflammatory condition of the large intestine that damages the gut wall. The exact cause is not well known. It usually begins in the rectum and can extend through the colon, leading to symptoms like bloody diarrhea, abdominal pain, and urgency.
Comparing Symptoms
Overlapping Symptoms
- Abdominal pain or cramping
- Diarrhea or changes in bowel habits
- Rectal bleeding
- Fatigue or low energy
Diverticulitis Specific Symptoms
- Sudden, sharp pain (usually lower left abdomen)
- Fever and chills
- Nausea and vomiting
- Constipation or bloating
- Typically occurs in flare-ups with symptom-free periods
Ulcerative Colitis Specific Symptoms
- Chronic diarrhea, often with blood or pus
- Urgency and frequent need to pass stool
- Weight loss and poor appetite
- Continuous symptoms or periodic flares
- Often associated with autoimmune symptoms like joint pain or eye inflammation
Treatment Approaches
Diverticulitis Treatment Approaches
Treatment typically includes a liquid/light diet and antibiotics until symptoms improve. In severe cases with complications or those who don't respond to medical treatment, surgery may be needed.
Ulcerative Colitis Treatment Approaches
Treatment includes medications to reduce inflammation and suppress the immune system. Lifestyle changes like a modified diet and stress reduction may be helpful. In severe cases, hospitalization for intravenous hydration, and surgery to remove part of the large intestine may be needed.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on May 1, 2025
Following the Medical Content Editorial Policy
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https://www.sciencedirect.com/science/article/abs/pii/S088985532030073X?via%3DihubEllison DL. Acute Diverticulitis Management. Crit Care Nurs Clin North Am. 2018 Mar;30(1):67-74. doi: 10.1016/j.cnc.2017.10.006. Epub 2017 Nov 29. PMID: 29413216.
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