Overview
Both IBS and Crohn's Disease can cause abdominal pain, diarrhea, and changes in bowel habits, making them difficult to distinguish without medical evaluation. While IBS is a functional disorder that doesn't cause physical damage to the digestive tract, Crohn's disease is an inflammatory condition that can cause tissue damage and complications.
Disease Summaries
IBS: It is a condition with recurring episodes of abdominal discomfort, diarrhea, and constipation. IBS (irritable bowel syndrome) is diagnosed when no clear cause can be found despite investigations. The exact cause of IBS is unknown, but stress and certain foods are known to cause flare-ups.
Crohn's Disease: It is an inflammatory condition of the gut. It is part of a group of diseases known as inflammatory bowel disease or IBD. It can affect anywhere from the mouth to the anus (end of the bowel).The exact cause is not well known.
Comparing Symptoms
Overlapping Symptoms
- Abdominal pain
- Diarrhea
- Fatigue
- Reduced appetite
- Bloating
IBS Specific Symptoms
- Pain relieved by bowel movements
- Symptoms triggered by stress
- No inflammation
- No weight loss
- Mucus in stool
Crohn's Disease Specific Symptoms
- Persistent fever
- Unintended weight loss
- Blood in stool
- Mouth sores
- Joint pain
Treatment Approaches
IBS Treatment Approaches
Treatment involves dietary modifications to identify and avoid trigger foods, stress management techniques, and medications to control specific symptoms like diarrhea or constipation. Probiotics and fiber supplements may be helpful for some patients. Psychological support through cognitive behavioral therapy can help manage stress-related symptoms.
Crohn's Disease Treatment Approaches
Treatment includes anti-inflammatory medications, immune system suppressors, and biologics to control inflammation and prevent flare-ups. Nutritional support and dietary modifications play a crucial role in management. Surgery may be needed for complications, and lifestyle changes such as stress management and smoking cessation are important for maintaining remission.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Mar 13, 2024
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Feuerstein JD, Cheifetz AS (2017). Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clinic proceedings.
https://pubmed.ncbi.nlm.nih.gov/28601423/Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE (2018). ACG Clinical Guideline: Management of Crohn's Disease in Adults. The American journal of gastroenterology.
https://pubmed.ncbi.nlm.nih.gov/29610508/Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora's box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89. PMID: 28702130; PMCID: PMC5495893.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495893/