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Stomach ache
Abdominal pain
Bloating
Diarrhea
Constipation
Stomach pain with diarrhea
Mucus in stool
My stomach is rumbling
Stomach ache after eating
Loose stool not diarrhea
Pressure and fullness in upper abdomen
Lower abdominal pain
Not seeing your symptoms? No worries!
A condition with recurring episodes of abdominal discomfort, diarrhea, and constipation. IBS is diagnosed when no clear cause can be found despite investigations. The exact cause of IBS is unknown, but stress and certain foods are known to cause flare-ups.
Your doctor may ask these questions to check for this disease:
IBS is treated by avoiding triggers and alleviating symptoms. Identifying triggers like dairy, beans, fried food, or stress may help. The doctor may prescribe medications to relieve symptoms of diarrhea or stomach cramps. A FODMAPs diet may also be effective.
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Nov 15, 2024
Following the Medical Content Editorial Policy
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Q.
Bloody diarrhea—when is this an “ER now” problem?
A.
Go to the ER now if you have heavy or frequent bleeding or clots, severe abdominal pain, fever of 101 F or higher, signs of dehydration, dizziness or fainting, confusion, a rapid heartbeat or low blood pressure, you are pregnant or immunocompromised, have major conditions like heart, kidney, or liver disease, or you have a sudden severe IBD flare. If symptoms are mild, with fewer than 3 bloody stools a day, no or low grade fever, and you can drink and urinate, you can monitor closely, hydrate, and see a doctor within 24 to 48 hours. There are several factors to consider, and key causes, red flags, safe home care, and what to expect in the ER are explained below.
References:
Foxx-Orenstein AE, & McFarland LV. (2010). Approach to the adult patient with acute diarrhea: a clinical… Mayo Clin Proc, 20588852.
https://pubmed.ncbi.nlm.nih.gov/20588852/
Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver disease. Hepatology, 11157951.
https://pubmed.ncbi.nlm.nih.gov/11157951/
European Association for the Study of the Liver. (2014). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology, 24986678.
Q.
Can’t stop pooping: when does this become a red-flag symptom doctors take seriously?
A.
Doctors take persistent diarrhea seriously when key red flags are present: blood or pus, high fever, severe abdominal pain, signs of dehydration, unintentional weight loss, symptoms lasting more than 48 hours, recent antibiotics or travel, older age, or immunocompromise; see below for the full list and what to do next. These signs may point to infections like C. difficile, inflammatory bowel disease, malabsorption, or dangerous complications such as severe dehydration or acute kidney injury, so seek urgent care if any occur. There are several factors to consider, and the detailed guidance below explains self-care, when to see a doctor, and the tests doctors use.
References:
Foxx-Orenstein AE, & McFarland LV. (2010). Approach to the adult patient with acute diarrhea: a clinical… Mayo Clin Proc, 20588852.
https://pubmed.ncbi.nlm.nih.gov/20588852/
Wai CT, Greenson JK, & Fontana RJ. (2003). A simple noninvasive index can predict both significant fibrosis… Hepatology, 12703719.
https://pubmed.ncbi.nlm.nih.gov/12703719/
European Association for the Study of the Liver. (2014). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology, 24986678.
Q.
Chronic diarrhea—what if your gut is inflamed, not “sensitive”?
A.
There are several factors to consider. Chronic diarrhea lasting 4 or more weeks can reflect true gut inflammation rather than a sensitive gut, often from inflammatory bowel disease, microscopic colitis, or bile acid malabsorption; see below for specifics that could change your next steps. Red flags and tests that help distinguish causes include blood in stool, weight loss, anemia or fever, fecal calprotectin or lactoferrin and, if elevated, colonoscopy with biopsies, with treatments that differ from IBS such as anti-inflammatory drugs, bile acid binders and targeted nutrition; find the full checklist and when to seek urgent care below.
References:
Heida A, Keszthelyi D, & Masclee AA. (2013). Value of fecal biomarkers in diagnosis and monitoring patients wit… Annals of Gastroenterology, 23963732.
https://pubmed.ncbi.nlm.nih.gov/23963732/
Tsochatzis EA, Gurusamy KS, & Ntaoula S. (2011). Elastography for the diagnosis of severity of fibrosis in chronic l… Journal of Hepatology, 21761531.
https://pubmed.ncbi.nlm.nih.gov/21761531/
D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a systematic… Journal of Hepatology, 16516658.
Q.
Diarrhea for weeks: what causes persist past a virus, and what should you test?
A.
When diarrhea lasts weeks, look beyond a virus: common causes include postinfectious IBS, inflammatory or microscopic colitis, malabsorption such as celiac, pancreatic insufficiency or bile acid diarrhea, chronic infections or parasites, medication effects including C. difficile, endocrine issues like hyperthyroidism or diabetic neuropathy, and liver disease; there are several factors to consider, and key nuances that can change your next steps are outlined below. Useful tests include blood work for anemia, inflammation, electrolytes, liver and thyroid function; stool studies for culture, ova and parasites, C. difficile, fecal calprotectin and fat or elastase; celiac antibodies and breath tests for lactose or SIBO; and, when indicated, colonoscopy with biopsies or imaging. Seek prompt care for red flags like bleeding, fever, severe pain, dehydration or weight loss, and see below for full details and step-by-step guidance.
References:
Stevens T, Potter M, Cohen S, Rosberg M, & Fried M. (2008). Etiology, diagnostic approach, and outcome of chronic diarrhea in a tertiar… Clin Gastroenterol Hepatol, 18089189.
https://pubmed.ncbi.nlm.nih.gov/18089189/
Spiller R. (2006). Postinfectious irritable bowel syndrome. Curr Gastroenterol Rep, 16917587.
https://pubmed.ncbi.nlm.nih.gov/16917587/
D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis… Journal of Hepatology, 16337436.
Q.
Diarrhea with mucus: what does mucus suggest about inflammation in the gut?
A.
Mucus in diarrhea usually signals irritation or inflammation of the colon lining, as goblet cells ramp up mucin to protect an inflamed gut; mucus with blood, fever, or severe abdominal pain is more suggestive of an inflammatory or invasive process than a simple viral upset. There are several factors to consider, and mucus can also occur in IBS without true inflammation; see below for key causes, red flags that warrant medical care, and the diagnostic and treatment options that could shape your next steps.
References:
Foxx-Orenstein AE, & McFarland LV. (2010). Approach to the adult patient with acute diarrhea: a clinical… Mayo Clin Proc, 20588852.
https://pubmed.ncbi.nlm.nih.gov/20588852/
Johansson ME, Larsson JM, Hansson GC. (2012). The two mucus layers of colon are organized by the MUC2 mucin… Proc Natl Acad Sci U S A, 22058291.
https://pubmed.ncbi.nlm.nih.gov/22058291/
Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver… Hepatology, 11157951.
Q.
Fatigue and diarrhea—what if your tiredness is coming from your gut?
A.
Fatigue with diarrhea often points to a gut cause, driven by inflammation, nutrient and fluid losses, or microbiome imbalance, with common culprits including IBD, bile acid diarrhea, infections, liver disease, and malabsorption issues like celiac disease or SIBO. There are several factors to consider, including urgent red flags, the tests doctors use, and proven treatments from medications and diet to supplements, probiotics, and self care; see below for the details that can shape your next steps.
References:
Graff LA, & Walker JR. (2010). Fatigue in patients with inflammatory bowel disease: prevalen… Inflamm Bowel Dis, 20441821.
https://pubmed.ncbi.nlm.nih.gov/20441821/
Camilleri M. (2015). Bile acid diarrhea: pathophysiology, diagnosis, and manag… Clin Gastroenterol Hepatol, 26004922.
https://pubmed.ncbi.nlm.nih.gov/26004922/
D’Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indic… J Hepatol, 16325192.
Q.
Fecal calprotectin—could one stool test end months of guessing?
A.
A fecal calprotectin stool test can rapidly indicate whether gut symptoms are due to intestinal inflammation, helping tell IBD from IBS and sometimes sparing you an immediate colonoscopy. Low values make significant inflammation unlikely, while higher results point to active inflammation and the need for further evaluation. There are several factors to consider, including infections, medicines like NSAIDs, and how to act on borderline results. See complete details below, including result ranges, when to repeat testing, red flags that need urgent care, and how this test fits into your next steps.
References:
Costa F, Mumolo MG, Seegers V, Bellini M, Romano MR, Borrelli O, Camilleri M. (2005). Faecal calprotectin: a surrogate marker of intestinal inflammation in… Eur J Gastroenterol Hepatol, 15801221.
https://pubmed.ncbi.nlm.nih.gov/15801221/
Tibble JA, Sigthorsson G, Bridger S, Fagerhol MK, Bjarnason I. (2000). Surrogate markers of intestinal inflammation are predictive of relapse in… Gut, 10859218.
https://pubmed.ncbi.nlm.nih.gov/10859218/
Foucher J, Chanteloup E, Vergniol J, Castéra L, Le Bail B, Adhoute X, Bertet J, Couzigou P, de Lédinghen V. (2006). Diagnosis of cirrhosis by transient elastography: a prospec… Hepatology, 16961053.
Q.
If diarrhea wakes you up at night, what are you supposed to suspect?
A.
Nighttime diarrhea usually points to an organic cause rather than typical daytime IBS; key suspects include infections, inflammatory bowel disease, malabsorption such as celiac or bile acid diarrhea, hormonal issues like hyperthyroidism, medication effects, and complications of advanced liver disease. There are several factors to consider, and red flags like blood in the stool, fever, weight loss, severe abdominal pain, dehydration, or jaundice need prompt care; see below for the full list of causes, alarm signs, and how doctors evaluate and treat this.
References:
Chey WD, Grunwald GK, & DeLee R. (2010). Chronic diarrhea: a practical… Cleve Clin J Med, 20843474.
https://pubmed.ncbi.nlm.nih.gov/20843474/
European Association for the Study of the Liver. (2018). EASL clinical practice guidelines for decompensated cirrhosis. Journal of Hepatology, 29710135.
https://pubmed.ncbi.nlm.nih.gov/29710135/
Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver disease. Hepatology, 11157951.
Q.
Lower abdominal pain and diarrhea—why do the location details matter so much?
A.
Where your lower abdominal pain sits with diarrhea is a key clue that narrows causes and directs testing, for example right-sided pain pointing toward appendicitis or Crohn's, left-sided toward diverticulitis or ulcerative colitis, and midline toward bladder, uterus, or small bowel issues. There are several factors to consider. See below for the full list of causes, red flags that require urgent care, how diarrhea changes the picture, and the tests and treatments that can guide your next steps.
References:
Ford AC, Lacy BE, Talley NJ. (2017). Irritable bowel syndrome. N Engl J Med, 28177869.
https://pubmed.ncbi.nlm.nih.gov/28177869/
D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cir… Journal of Hepatology, 16219970.
https://pubmed.ncbi.nlm.nih.gov/16219970/
Angeli P, Bernardi M, Villanueva C, Francoz C, Caraceni P, Trebicka J, Arroyo V, Kamath PS. (2018). EASL Clinical Practice Guidelines for the management of pati… Journal of Hepatology, 29677121.
Q.
Rectal bleeding: what symptoms make it more likely inflammation vs a tear?
A.
There are several factors to consider. Diarrhea, urgency or tenesmus, cramping, mucus or pus, and systemic signs like fever, fatigue, or weight loss suggest inflammation, whereas small amounts of bright red blood on the paper or stool surface with sharp, well localized pain during or after a bowel movement, often after constipation, suggest an anal tear. See below for key red flags that need urgent care such as heavy bleeding, dizziness or fainting, black tarry stools, severe abdominal pain, or high fever, plus evaluation steps and treatments that can guide your next steps.
References:
Pardi DS, Tremaine WJ, Sandborn WJ, & Zinsmeister AR. (2001). Predicting inflammatory bowel disease among patients with rectal b… Am J Gastroenterol, 11467946.
https://pubmed.ncbi.nlm.nih.gov/11467946/
Strate LL, & Gralnek IM. (2016). ACG clinical guideline: management of patients with acute lower g… Am J Gastroenterol, 26757492.
https://pubmed.ncbi.nlm.nih.gov/26757492/
D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrh… Hepatology, 16899897.
Q.
Right lower abdominal pain and diarrhea: what diagnoses are usually considered first?
A.
First-line diagnoses include acute appendicitis, infectious ileocolitis (Yersinia, Salmonella, Campylobacter, C. difficile, parasites), and Crohn’s disease of the terminal ileum. Depending on age and risk factors, clinicians also consider mesenteric adenitis, IBS, NSAID enteropathy, and less commonly Meckel’s diverticulitis, ileocecal tuberculosis, ischemia, or tumors; important red flags and next tests are outlined below.
References:
Rieder F, & Fiocchi C. (2014). Differential diagnosis of ileitis: when it is not Crohn’s disease… Gastroenterology Clinics of North America, 25499990.
https://pubmed.ncbi.nlm.nih.gov/25499990/
Bottone EJ. (1997). Yersinia enterocolitica: a brief review of the role of pigs as a reservoir… Clinical Infectious Diseases, 9233542.
https://pubmed.ncbi.nlm.nih.gov/9233542/
Kim WR, & Kamath PS. (2021). Model for end‐stage liver disease (MELD) 3.0: updated calibration and validation in patients with cirrhosis… Hepatology, 34103975.
Q.
Sensation of incomplete evacuation: what does this symptom mean clinically?
A.
Clinically, the sensation of incomplete evacuation is the feeling that stool remains after a bowel movement even when the rectum is empty, most often tied to functional anorectal disorders like dyssynergic defecation or IBS-C, though structural issues such as rectocele or rectal prolapse can also play a role. There are several factors to consider, and appropriate next steps often include a focused history and exam, possible anorectal testing, and first-line care with fiber, hydration, pelvic floor physical therapy, and cautious use of laxatives, with urgent evaluation for red flags like bleeding, weight loss, or severe pain. See below to understand more.
References:
Bharucha AE, Wald A, & Enck P. (2016). Functional anorectal disorders… Gastroenterology, 27261812.
https://pubmed.ncbi.nlm.nih.gov/27261812/
D’Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis… Journal of Hepatology, 16879838.
https://pubmed.ncbi.nlm.nih.gov/16879838/
Castera L, Forns X, & Alberti A. (2008). Non-invasive evaluation of liver fibrosis using transient elastography… Journal of Hepatology, 18295713.
Q.
Urgent diarrhea: what does urgency suggest about the colon and rectum?
A.
Urgent diarrhea usually points to involvement of the distal colon and rectum, where inflammation or irritation reduces storage capacity, speeds transit, and makes the rectum hypersensitive with poor compliance. This leads to rapid, loose stools, tenesmus, and a strong need to pass small amounts of stool or mucus. There are several factors to consider, including infectious colitis, inflammatory bowel disease, IBS-D, radiation or ischemic injury, and medication effects, along with red flags that may require urgent care; see below to understand more.
References:
Riddle MS, Connor BA, Rao M, Sanders JW, Porter CK. (2016). ACG Clinical Guideline: diagnosis, treatment, and prevention of acute… Am J Gastroenterol, 27301435.
https://pubmed.ncbi.nlm.nih.gov/27301435/
Tsochatzis EA, Bosch J, Burroughs AK. (2014). Liver cirrhosis. Lancet, 24613338.
https://pubmed.ncbi.nlm.nih.gov/24613338/
Foucher J, Chanteloup E, Vergniol J, et al. (2006). Diagnosis of cirrhosis by transient elastography (FibroScan): a prospec… Gastroenterology, 16697759.
Q.
Urgent need to poop: what symptoms point to inflammatory bowel disease?
A.
Persistent urgent diarrhea, especially at night, with blood or mucus, abdominal cramping, tenesmus, unexplained weight loss, and fatigue suggests inflammatory bowel disease rather than IBS; extra clues outside the gut include joint pain or swelling, skin rashes, and eye inflammation. There are several factors to consider; see below for the key differences from IBS and the specific tests and red flags that guide next steps, including fecal calprotectin, blood work for inflammation and anemia, colonoscopy with biopsy, and imaging.
References:
Maaser C, Sturm A, Vavricka SR, et al. (2019). ECCO-ESGAR Guideline for Diagnostic Assessment in IBD: initial… Journal of Crohn’s and Colitis, 31104639.
https://pubmed.ncbi.nlm.nih.gov/31104639/
Halpin SJ, & Ford AC. (2012). Prevalence of IBS-type symptoms in inflammatory bowel… American Journal of Gastroenterology, 22745188.
https://pubmed.ncbi.nlm.nih.gov/22745188/
Merli M, Giannelli V, De Santis A, et al. (2011). Thrombocytopenia is associated with increased mortality in… Clinical Gastroenterology and Hepatology, 21473902.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora's box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89. PMID: 28702130; PMCID: PMC5495893.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495893/Fond G, Loundou A, Hamdani N, Boukouaci W, Dargel A, Oliveira J, Roger M, Tamouza R, Leboyer M, Boyer L. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):651-60. doi: 10.1007/s00406-014-0502-z. Epub 2014 Apr 6. PMID: 24705634.
https://link.springer.com/article/10.1007/s00406-014-0502-zAltomare A, Di Rosa C, Imperia E, Emerenziani S, Cicala M, Guarino MPL. Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms. Nutrients. 2021 Apr 29;13(5):1506. doi: 10.3390/nu13051506. PMID: 33946961; PMCID: PMC8146452.
https://www.mdpi.com/2072-6643/13/5/1506Nee J, Lembo A. Review Article: Current and future treatment approaches for IBS with diarrhoea (IBS-D) and IBS mixed pattern (IBS-M). Aliment Pharmacol Ther. 2021 Dec;54 Suppl 1:S63-S74. doi: 10.1111/apt.16625. PMID: 34927757.
https://onlinelibrary.wiley.com/doi/10.1111/apt.16625