Overview
IBS and IBD can both cause abdominal pain and altered bowel habits. IBS is a non-inflammatory condition without structural damage, while IBD (like Crohn's disease or ulcerative colitis) involves chronic inflammation and can lead to complications. Diagnosis typically requires imaging and lab tests.
Disease Summaries
IBS: Irritable Bowel Syndrome (IBS) is a condition with recurring episodes of abdominal discomfort, diarrhea, and constipation. IBS is diagnosed when no clear cause can be found despite investigations. The exact cause of IBS is unknown, but stress and certain foods are known to cause flare-ups.
IBD: Inflammatory Bowel Disease (IBD), including Crohn's disease and ulcerative colitis, is a group of chronic conditions that cause inflammation of the digestive tract. Crohn's disease can affect any part of the gastrointestinal tract and often involves deeper tissue layers, while ulcerative colitis primarily affects the colon and rectum. Symptoms include abdominal pain, persistent diarrhea (sometimes with blood), weight loss, and fatigue. IBD typically follows a relapsing-remitting course, with periods of flare-ups and remission.
Comparing Symptoms
Overlapping Symptoms
- Abdominal pain
- Diarrhea
- Bloating
- Urgency to defecate
- Fatigue
IBS Specific Symptoms
- Pain relieved by bowel movements
- Symptoms triggered by stress or certain foods
- No inflammation
- Alternating constipation and diarrhea
- Normal colonoscopy
IBD Specific Symptoms
- Blood in stool
- Weight loss
- Fever during flares
- Inflammation visible on imaging
- Risk of intestinal damage or surgery
Treatment Approaches
IBS Treatment Approaches
Treatment involves dietary modifications to identify and avoid trigger foods, stress management techniques, and medications to control specific symptoms like diarrhea or constipation. Probiotics and fiber supplements may be helpful for some patients. Psychological support through cognitive behavioral therapy can help manage stress-related symptoms.
IBD Treatment Approaches
IBD is typically managed with anti-inflammatory medications, immunosuppressants, and biologic therapies that target specific parts of the immune system. In some cases, surgical intervention may be necessary to remove damaged sections of the intestine, particularly in severe or treatment-resistant cases.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Mar 27, 2024
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Feuerstein JD, Cheifetz AS (2017). Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clinic proceedings.
https://pubmed.ncbi.nlm.nih.gov/28601423/Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE (2018). ACG Clinical Guideline: Management of Crohn's Disease in Adults. The American journal of gastroenterology.
https://pubmed.ncbi.nlm.nih.gov/29610508/Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora's box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89. PMID: 28702130; PMCID: PMC5495893.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495893/