Overview
Lupus and multiple sclerosis are both autoimmune diseases but affect different parts of the body. Lupus often causes joint pain, rashes, and organ inflammation, while MS primarily affects the nervous system, leading to weakness, vision problems, and coordination issues.
Disease Summaries
Lupus: This is an autoimmune disease caused by the body's immune system attacking organs and cells. The exact cause is unclear, but risk factors include being female, especialy of childbearing age, and heredity. Lupus (SLE) may involve nearly every organ system in the body with a wide range of potential symptoms that often wax and wane over time.
Multiple Sclerosis: This is a condition where the immune system attacks parts of the brain and spinal cord. The direct cause of MS remains unknown, but certain risk factors have been identified such as low vitamin D levels, tobacco smoking, exposure to UV radiation, childhood obesity, and infection with the virus that causes mononucleosis. The disease tends to affect young people more commonly as well as people living in higher latitudes. MS typically occurs in "attacks" which can include but are not limited to painful eye movements, blurry vision in one eye, numbness or weakness in hands or feet on one side, or double vision.
Comparing Symptoms
Overlapping Symptoms
- Fatigue
- Cognitive issues ("brain fog")
- Muscle weakness
- Numbness or tingling
- Mood changes
Lupus Specific Symptoms
- Butterfly-shaped facial rash
- Joint pain and swelling
- Photosensitivity
- Mouth ulcers
- Kidney involvement
Multiple Sclerosis Specific Symptoms
- Vision problems
- Balance issues
- Muscle weakness
- Symptoms vary by nerve involved
- Heat sensitivity
Treatment Approaches
Lupus Treatment Approaches
Though there is no cure, treatment aims to keep the disease inactive and ease symptoms. This is done through medications that suppress or modify the immune system. Creams can be given for rashes, and anti-inflammatory medicines and painkillers for joint pain.
Multiple Sclerosis Treatment Approaches
Treatment of MS includes medications, physical/occupational therapy, lifestyle changes, and psychological support. Some medications prevent immune system attacks on the central nervous system, whereas others speed up recovery from attacks, or others reduce MS symptoms such as urinary problems or imbalanced walking. Physical therapy accelerates recovery from attacks and Lifestyle changes like quitting smoking can help reduce risk of further attacks.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Content updated on Mar 27, 2024
Following the Medical Content Editorial Policy
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https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
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https://pubmed.ncbi.nlm.nih.gov/35804480/Siegel CH, Sammaritano LR (Year). Systemic Lupus Erythematosus: A Review. JAMA.
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