Systemic Lupus Erythematosus (SLE) Quiz
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Rashes
Extreme tiredness
Sudden tiredness during the day
Joint pain
Both hips hurt
Heat rash
Chronic fatigue syndrome
Heat exhaustion
Fever
Chills but no fever
Butterfly rash
Erythema
Not seeing your symptoms? No worries!
What is Systemic Lupus Erythematosus (SLE)?
An autoimmune disease caused by the body's immune system attacking organs and cells. The exact cause is unclear, but risk factors include being female, childbearing age, and heredity. SLE may involve nearly every organ system in the body with a wide range of potential symptoms that often wax and wane over time.
Typical Symptoms of Systemic Lupus Erythematosus (SLE)
- Whole body pain
- Hair loss
- History of connective tissue, autoimmune or rheumatic disease
- Warmth in the joints
- Fatigue or low energy that is worse in the morning
- Red rash over cheeks
- Skin over the entire body is red
- Fever
Diagnostic Questions for Systemic Lupus Erythematosus (SLE)
Your doctor may ask these questions to check for this disease:
- Do you have pain all over your body?
- Are you experiencing increased hair loss?
- Have you ever been diagnosed with a connective tissue, autoimmune, or rheumatic disease?
- Do you feel warmth in your joints?
- Do you experience fatigue or low energy that is worse in the morning?
Treatment of Systemic Lupus Erythematosus (SLE)
Though there is no cure, treatment aims to keep the disease inactive and ease symptoms. This is done through medications that suppress or modify the immune system. Creams can be given for rashes, and anti-inflammatory medicines and painkillers for joint pain.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Kaito Nakamura, MD (Rheumatology)
Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.
Content updated on Feb 19, 2025
Following the Medical Content Editorial Policy
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How Ubie Can Help You
With a free 3-min Systemic Lupus Erythematosus (SLE) quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
Your symptoms
Our AI
Your report
Your personal report will tell you
✔ When to see a doctor
✔︎ What causes your symptoms
✔︎ Treatment information etc.
People with similar symptoms also use Ubie's symptom checker to find possible causes
- My whole body aches and I feel weak
- Loss of hair
- Body aches and chills
- Joint pain and stiffness all over body
- One or more joints feel warm
- Thinning hair
- Whole body aches no fever
- My whole body hurts
- Bald spots
- Whole body pain
- Knees hot, no pain
- Patchy hair loss
- Receding hairline
- Joint pain and redness
- Before the hair loss, the scalp was itchy
See full list
User Testimonials for Systemic Lupus Erythematosus (SLE)
Female, 30s
I have already seen a rheumatologist within the past year because of a positive ANA result. Not my favorite doctor, to put it politely. My PCP wants to refer me for a second opinion to another rheumatologist because she believes I might have lupus. I was surprised to see that the first result Ubie gave based on my symptoms was SLE (lupus). I downloaded the report to show her because it might be helpful in the future.
(Jul 30, 2025)
Female, 40s
Ubie gave me a direction to go in when looking into possible autoimmune immune symptoms. I found it very helpful. I now plan on booking an appointment and seeing a doctor soon.
(Jun 14, 2025)
Female, 30s
The downloadable symptoms list is a game-changer for me. Also, the suggestions for narrowing down on possible conditions. I found this website to be supremely helpful for me today with what I needed to accomplish. Thank you. I will book an appointment and see a doctor right away.
(Jun 12, 2025)
Female, 20s
I have been diagnosed with Ehlers-Danlos Syndrome, but recently have been thinking I have something that needs more intensive and direct treatment, like Multiple Sclerosis. Ubie suggested that I look at a couple different possible conditions, and I REALLY appreciated how detailed it was! I loved that I could add specifics and that it asked me to follow up on symptoms with more clarification. It genuinely feels like the people who developed Ubie care about helping people find the right resources and information to get an accurate diagnosis and find proper care. No other website has compared to my experience with Ubie, and as someone with a chronic disability, I have had an exorbitant amount of experience. The fact that this was all free was beyond my belief. I am amazed and grateful.
(May 21, 2025)
Symptoms Related to Systemic Lupus Erythematosus (SLE)
Diseases Related to Systemic Lupus Erythematosus (SLE)
FAQs
Q.
Bone-Deep Fatigue? Why Your Body is Attacking Itself & Your Lupus Roadmap
A.
Bone-deep fatigue, joint pain, rashes, and flares can signal lupus, an autoimmune disease where your immune system attacks healthy tissues in the joints, skin, kidneys, heart, lungs, brain, and blood, yet with early diagnosis and a personalized plan it is manageable. There are several factors to consider, including why the fatigue happens, how lupus is diagnosed, and a step-by-step roadmap for treatment, monitoring, flare prevention, energy support, organ protection, mental health, and urgent warning signs that could change your next steps. See the complete answer below to understand more.
References:
* Soria, A., et al. The Complex Nature of Fatigue in Systemic Lupus Erythematosus: A Comprehensive Review. *J Clin Med*. 2021 May 26;10(11):2347. doi: 10.3390/jcm10112347. PMID: 34070267. PMCID: PMC8197775.
* Tsokos, G. C., et al. Pathogenesis of systemic lupus erythematosus: an update. *Curr Opin Rheumatol*. 2022 Mar 1;34(2):107-113. doi: 10.1097/BOR.0000000000000867. PMID: 34964724.
* Fan, B., et al. Systemic lupus erythematosus: an update on the latest management guidelines and treatment strategies. *Ther Adv Musculoskelet Dis*. 2023 Apr 14;15:1759720X231165682. doi: 10.1177/1759720X231165682. PMID: 37077610. PMCID: PMC10098908.
* Bensadoun, E. S., et al. Neuropsychiatric manifestations of systemic lupus erythematosus: a review of the mechanisms and treatment. *Front Immunol*. 2023 Sep 11;14:1229712. doi: 10.3389/fimmu.2023.1229712. PMID: 37766922. PMCID: PMC10520697.
* Kneepkens, E. L., et al. Biomarkers of fatigue in systemic lupus erythematosus: a systematic review. *Lupus*. 2022 Sep;31(10):1153-1166. doi: 10.1177/09612033221106979. PMID: 35726666.
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Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Lazar S, Kahlenberg JM (Year). Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches. Annual review of medicine.
https://pubmed.ncbi.nlm.nih.gov/35804480/Arnaud L, Chasset F, Martin T (Year). Immunopathogenesis of systemic lupus erythematosus: An update. Autoimmunity reviews.
https://pubmed.ncbi.nlm.nih.gov/39343084/Siegel CH, Sammaritano LR (Year). Systemic Lupus Erythematosus: A Review. JAMA.
https://pubmed.ncbi.nlm.nih.gov/38587826/