Drug-Induced Hypersensitivity Syndrome Quiz

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Reviewed By:

Yuta Sasaoka, MD

Yuta Sasaoka, MD (Pediatrics)

Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.

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  • Fever then no fever then fever again

  • Periodic fever (>100.4°F / 38°C)

  • Easily tired

  • Remittent fever of 102.2°F / 39°C

  • Stomach was uncomfortable, then had a fever

  • Fatigue that varies throughout the day

  • Extremely high fever of 106.7°F / 41.5°C or higher

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Learn more about Drug-induced hypersensitivity syndrome

Content updated on Sep 20, 2022

What is drug-induced hypersensitivity syndrome?

Drug-induced hypersensitivity syndrome, also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe reaction to a drug marked by fever, rash, and multiorgan failure. It can happen between 1-8 weeks after taking the drug. Drugs that most often cause DRESS include certain anti-seizure medications like carbamazepine, phenytoin, and phenobarbital, as well as allopurinol, which is used for gout.

Symptoms of drug-induced hypersensitivity syndrome

  • Fever

  • Fatigue

  • Taking medication for seizures or epilepsy

  • Skin over the entire body is red

  • Swollen lymph nodes, usually small swellings at the neck, armpits, groin and behind the ears

  • Skin problem on the chest, tummy or back

  • Skin rashes with tiny bumps

  • Rashes or fever, 2 to 6 weeks after starting a new medication

Questions your doctor may ask to check for drug-induced hypersensitivity syndrome

Your doctor may ask these questions to diagnose drug-induced hypersensitivity syndrome

  • Do you have a fever?

  • Do you feel fatigued?

  • Are you currently taking medicine to prevent seizures?

  • Do you have skin redness over the whole body?

  • Do you feel your lymph nodes are swollen and enlarged?

Treatment for drug-induced hypersensitivity syndrome

Treatment involves immediately stopping the drug causing the reaction, followed by close monitoring and supportive care. In serious cases, doctors may prescribe systemic corticosteroids to reduce inflammation.

View the symptoms of Drug-induced hypersensitivity syndrome

Diseases related to Drug-induced hypersensitivity syndrome

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Reviewed By:

Yuta Sasaoka, MD

Yuta Sasaoka, MD (Pediatrics)

Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.

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