Drug-Induced Hypersensitivity Syndrome Quiz
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Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
Content updated on May 13, 2024
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Fatigued
Have a fever
Rashes
Feeling tired and no more energy
Simultaneous onset of fever and rash
Lymph swollen
There is a dry bumpy rash on the skin
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- Fever then no fever then fever again
- Swollen lymph nodes above collar bone
- Periodic fever (>100.4°F / 38°C)
- Swollen armpit
- Remittent fever of 102.2°F / 39°C
- Swollen lymph nodes continue to grow larger
- Stomach was uncomfortable, then had a fever
- Extremely high fever of 106.7°F / 41.5°C or higher
- It moves when I touch the lump
- Fever of 100.4°F / 38°C or more for weeks
- Multiple lymph nodes swollen in my groin
- Baby has a fever but is otherwise healthy and energetic
- Lymph nodes in the groin are swollen
- My body is hot
- Swollen lymph nodes
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Try Free Symptom QuizWhat is Drug-Induced Hypersensitivity Syndrome?
Drug-induced hypersensitivity syndrome, also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe reaction to a drug marked by fever, rash, and multiorgan failure. It can happen between 1-8 weeks after taking the drug. Drugs that most often cause DRESS include certain anti-seizure medications like carbamazepine, phenytoin, and phenobarbital, as well as allopurinol, which is used for gout.
Typical Symptoms of Drug-Induced Hypersensitivity Syndrome
- Taking medication for seizures or epilepsy
- Skin over the entire body is red
- Lymph node swelling that is persistent and increasing in size
- Fever
- Swollen lymph nodes, usually small swellings at the neck, armpits, groin and behind the ears
- Skin problem on the chest, tummy or back
- Skin rashes with tiny bumps
- Rashes or fever, 2 to 6 weeks after starting a new medication
Diagnostic Questions for Drug-Induced Hypersensitivity Syndrome
Your doctor may ask these questions to check for this disease:
- Are you on seizure medication?
- Is your whole body red?
- Are your swollen lymph nodes still getting bigger?
- Do you have a fever?
- Are your lymph nodes swollen and enlarged?
Treatment of Drug-Induced Hypersensitivity Syndrome
Treatment involves immediately stopping the drug causing the reaction, followed by close monitoring and supportive care. In serious cases, doctors may prescribe systemic corticosteroids to reduce inflammation.
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Drug-Induced Hypersensitivity Syndrome?
Try a symptom check testSymptoms related to Drug-Induced Hypersensitivity Syndrome
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References
Calle AM, Aguirre N, Ardila JC, Cardona Villa R. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organ J. 2023 Apr 8;16(3):100673. doi: 10.1016/j.waojou.2022.100673. PMID: 37082745; PMCID: PMC10112187.
https://pubmed.ncbi.nlm.nih.gov/37082745/
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Aug 30, 2024 (Female, 40s)
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
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Drug-Induced Hypersensitivity Syndrome?
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