Drug-Induced Hypersensitivity Syndrome Quiz
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Reviewed By:
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
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Fever then no fever then fever again
Periodic fever (>100.4°F / 38°C)
Easily tired
Remittent fever of 102.2°F / 39°C
Stomach was uncomfortable, then had a fever
Fatigue that varies throughout the day
Extremely high fever of 106.7°F / 41.5°C or higher
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Learn more about Drug-induced hypersensitivity syndrome
Content updated on Sep 20, 2022
What is drug-induced hypersensitivity syndrome?
Drug-induced hypersensitivity syndrome, also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe reaction to a drug marked by fever, rash, and multiorgan failure. It can happen between 1-8 weeks after taking the drug. Drugs that most often cause DRESS include certain anti-seizure medications like carbamazepine, phenytoin, and phenobarbital, as well as allopurinol, which is used for gout.
Symptoms of drug-induced hypersensitivity syndrome
Fever
Fatigue
Taking medication for seizures or epilepsy
Skin over the entire body is red
Swollen lymph nodes, usually small swellings at the neck, armpits, groin and behind the ears
Skin problem on the chest, tummy or back
Skin rashes with tiny bumps
Rashes or fever, 2 to 6 weeks after starting a new medication
Questions your doctor may ask to check for drug-induced hypersensitivity syndrome
Your doctor may ask these questions to diagnose drug-induced hypersensitivity syndrome
Do you have a fever?
Do you feel fatigued?
Are you currently taking medicine to prevent seizures?
Do you have skin redness over the whole body?
Do you feel your lymph nodes are swollen and enlarged?
Treatment for drug-induced hypersensitivity syndrome
Treatment involves immediately stopping the drug causing the reaction, followed by close monitoring and supportive care. In serious cases, doctors may prescribe systemic corticosteroids to reduce inflammation.
View the symptoms of Drug-induced hypersensitivity syndrome
Diseases related to Drug-induced hypersensitivity syndrome
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Reviewed By:
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
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Dale Mueller, MD
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