Drug-Induced Hypersensitivity Syndrome Quiz
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Reviewed By:
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
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Learn more about Drug-induced hypersensitivity syndrome
Content updated on Sep 20, 2022
What is drug-induced hypersensitivity syndrome?
Drug-induced hypersensitivity syndrome, also called drug rash with eosinophilia and systemic symptoms (DRESS), is a severe reaction to a drug characterized by fever, rash and multiorgan failure. It can occur anytime between 1-8 weeks after drug introduction. Drugs that most commonly cause DRESS include certain anti-seizures such as carbamazepine, phenytoin and phenobarbital, as well as allopurinol which is used for gout.
Symptoms of drug-induced hypersensitivity syndrome
Fever
Fatigue
Taking medication for seizures or epilepsy
Skin over the entire body is red
Swollen lymph nodes, usually small swellings at the neck, armpits, groin and behind the ears
Skin problem on the chest, tummy or back
Skin rashes with tiny bumps
Rashes or fever, 2 to 6 weeks after starting a new medication
Questions your doctor may ask to check for drug-induced hypersensitivity syndrome
Your doctor may ask these questions to diagnose drug-induced hypersensitivity syndrome
Do you have a fever?
Do you feel fatigued?
Are you currently taking medicine to prevent seizures?
Do you have skin redness over the whole body?
Do you feel your lymph nodes are swollen and enlarged?
Treatment for drug-induced hypersensitivity syndrome
Treatment includes immediate withdrawal of the causative drug followed by careful monitoring and supportive care. In severe cases, systemic corticosteroids to suppress inflammation may be prescribed by the doctor.
View the symptoms of Drug-induced hypersensitivity syndrome
Diseases related to Drug-induced hypersensitivity syndrome
Reviewed By:
Yuta Sasaoka, MD (Pediatrics)
Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.
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Seiji Kanazawa, MD, PHD
Obstetrics and gynecology (OBGYN)
National Center for Child Health and Development, Japan