Paroxysmal Kinesigenic Dyskinesia Quiz
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Uncontrolled movements
Hands have fine tremors
My body is jerking
Recently had a seizure
Involuntary movements
Seizures
Fine finger tremor
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What is Paroxysmal Kinesigenic Dyskinesia?
Paroxysmal exercise-induced dyskinesia (PED) is a movement disorder that is characterized by involuntary, irregular, unpredictable muscle movements triggered by exercise. People with PED appear as if they are dancing, restless, or fidgety. This disorder is caused by a mutation in the SLC2A1 gene.
Typical Symptoms of Paroxysmal Kinesigenic Dyskinesia
- Seizure
- Uncontrollable movements
- Seizures within the last 1 week
- Fine tremors of the hands or fingers
- The hand or leg on one side occasionally jerks or makes a sudden movement
- More than 1 episode of seizures within 24 hours
- Recurrent seizures
- Seizure with movements on only one side of the body
Diagnostic Questions for Paroxysmal Kinesigenic Dyskinesia
Your doctor may ask these questions to check for this disease:
- Have you experienced any seizures?
- Do you have uncontrollable movements in your hands, legs, or face?
- Did you have a seizure in the past week?
- Do you experience fine tremors in your hands or fingers?
- Have you had multiple seizures in the past 24 hours?
Treatment of Paroxysmal Kinesigenic Dyskinesia
Treatment depends on the condition's severity. Avoiding exercise triggers may greatly help with symptoms. Deep brain stimulation or surgery can also be offered in cases of severe impairment and when all other treatments have failed.
Reviewed By:
Benjamin Kummer, MD (Neurology)
Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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- Twitching
- Fever seizures (with fever of >100.4°F / 38°C)
- Shaking hands
- Slow twitching of arms and legs
- Seizures without fever
- Limb spasms on one side in the morning when waking up
- The first seizure
- Twitching in one side of the body
- Repetitive seizures
- Seizure with fainting
- Hand twitching
- Involuntary movements at night
- Seizures when I wake up
- I have a seizure that is not symmetric
- Right hand and leg jerks when I am about to wake up
See full list
Symptoms Related to Paroxysmal Kinesigenic Dyskinesia
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Erro R, Magrinelli F, Bhatia KP. Paroxysmal movement disorders: Paroxysmal dyskinesia and episodic ataxia. Handb Clin Neurol. 2023;196:347-365. doi: 10.1016/B978-0-323-98817-9.00033-8. PMID: 37620078.
https://www.sciencedirect.com/science/article/abs/pii/B9780323988179000338?via%3DihubBhatia KP. Paroxysmal dyskinesias. Mov Disord. 2011 May;26(6):1157-65. doi: 10.1002/mds.23765. PMID: 21626559.
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.23765Latorre A, Bhatia KP. Treatment of Paroxysmal Dyskinesia. Neurol Clin. 2020 May;38(2):433-447. doi: 10.1016/j.ncl.2020.01.007. PMID: 32279719.
https://www.sciencedirect.com/science/article/abs/pii/S0733861920300074?via%3DihubGardiner AR, Jaffer F, Dale RC, Labrum R, Erro R, Meyer E, Xiromerisiou G, Stamelou M, Walker M, Kullmann D, Warner T, Jarman P, Hanna M, Kurian MA, Bhatia KP, Houlden H. The clinical and genetic heterogeneity of paroxysmal dyskinesias. Brain. 2015 Dec;138(Pt 12):3567-80. doi: 10.1093/brain/awv310. Epub 2015 Nov 23. PMID: 26598494; PMCID: PMC4655345.
https://academic.oup.com/brain/article/138/12/3567/415439?login=falseBhatia KP, Marsden CD, Thomas DG. Posteroventral pallidotomy can ameliorate attacks of paroxysmal dystonia induced by exercise. J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):604-5. doi: 10.1136/jnnp.65.4.604a. PMID: 9771800; PMCID: PMC2170286.
https://jnnp.bmj.com/content/65/4/604.2