Paroxysmal Kinesigenic Dyskinesia Quiz

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Benjamin Kummer, MD

Benjamin Kummer, MD (Neurology)

Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

  • Twitching

  • Fever seizures (with fever of >100.4°F / 38°C)

  • Slow twitching of arms and legs

  • The first seizure

  • Limb spasms on one side in the morning when waking up

  • Repetitive seizures

  • Twitching in one side of the body

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Learn more about Paroxysmal Kinesigenic Dyskinesia

Content updated on Jan 19, 2024

What is paroxysmal kinesigenic dyskinesia?

Paroxysmal exercise-induced dyskinesia (PED) is a movement disorder that is characterized by involuntary, irregular, unpredictable muscle movements triggered by exercise. People with PED appear as if they are dancing, restless, or fidgety. This disorder is caused by a mutation in the SLC2A1 gene.

Symptoms of paroxysmal kinesigenic dyskinesia

  • Seizure

  • Uncontrollable movements

  • Seizures within the last 1 week

  • Fine tremor of the hands and fingers

  • The hand or leg on one side occasionally jerks or makes a sudden movement

  • More than 1 episode of seizures within 24 hours

  • Recurrent seizures

  • Seizure with movements on only one side of the body

Questions your doctor may ask to check for paroxysmal kinesigenic dyskinesia

  • Have you had a seizure?

  • Do you have uncontrollable movements in your hands, legs, or face?

  • Did you have a seizure in the past week?

  • Do your fingers tremble slightly?

  • Have you had multiple seizures in the past 24 hours?

Treatment for paroxysmal kinesigenic dyskinesia

Treatment depends on the condition's severity. Avoiding exercise triggers may greatly help with symptoms. Deep brain stimulation or surgery can also be offered in cases of severe impairment and when all other treatments have failed.

View the symptoms of Paroxysmal Kinesigenic Dyskinesia

References

  • Erro R, Magrinelli F, Bhatia KP. Paroxysmal movement disorders: Paroxysmal dyskinesia and episodic ataxia. Handb Clin Neurol. 2023;196:347-365. doi: 10.1016/B978-0-323-98817-9.00033-8. PMID: 37620078.

    https://www.sciencedirect.com/science/article/abs/pii/B9780323988179000338?via%3Dihub

  • Bhatia KP. Paroxysmal dyskinesias. Mov Disord. 2011 May;26(6):1157-65. doi: 10.1002/mds.23765. PMID: 21626559.

    https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.23765

  • Latorre A, Bhatia KP. Treatment of Paroxysmal Dyskinesia. Neurol Clin. 2020 May;38(2):433-447. doi: 10.1016/j.ncl.2020.01.007. PMID: 32279719.

    https://www.sciencedirect.com/science/article/abs/pii/S0733861920300074?via%3Dihub

  • Gardiner AR, Jaffer F, Dale RC, Labrum R, Erro R, Meyer E, Xiromerisiou G, Stamelou M, Walker M, Kullmann D, Warner T, Jarman P, Hanna M, Kurian MA, Bhatia KP, Houlden H. The clinical and genetic heterogeneity of paroxysmal dyskinesias. Brain. 2015 Dec;138(Pt 12):3567-80. doi: 10.1093/brain/awv310. Epub 2015 Nov 23. PMID: 26598494; PMCID: PMC4655345.

    https://academic.oup.com/brain/article/138/12/3567/415439?login=false

  • Bhatia KP, Marsden CD, Thomas DG. Posteroventral pallidotomy can ameliorate attacks of paroxysmal dystonia induced by exercise. J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):604-5. doi: 10.1136/jnnp.65.4.604a. PMID: 9771800; PMCID: PMC2170286.

    https://jnnp.bmj.com/content/65/4/604.2

User testimonials

Reviewed By:

Benjamin Kummer, MD

Benjamin Kummer, MD (Neurology)

Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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