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Published on: 10/30/2025
How much acetaminophen does it take to damage the liver?
Taking too much acetaminophen can hurt your liver. Usually, more than 4,000 milligrams in a day can be harmful. See below to understand more.
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Explanation
Acetaminophen is a common medicine used to relieve pain and reduce fever, but taking too much can be dangerous for your liver. According to the research, if an adult takes more than 4,000 milligrams of acetaminophen in one day, it can lead to liver damage.
Key Points:
- Safe Limit: Adults should not exceed 4,000 milligrams of acetaminophen in 24 hours.
- Chronic Use: Even lower doses taken over a long time can be harmful if used excessively.
- Symptoms of Damage: Signs of liver damage can include nausea, vomiting, and pain in the upper right side of the stomach.
It's important to always follow the dosage instructions on the medicine label or given by a doctor. If you think you have taken too much acetaminophen, seek medical help right away.
(References)
- Barker JD Jr, de Carle DJ, & Anuras S. (1977). Chronic excessive acetaminophen use and liver damage. Annals of internal medicine, 900673.
- Fisher ES, & Curry SC. (2019). Evaluation and treatment of acetaminophen toxicity. Advances in pharmacology (San Diego, Calif.), 31307590.
- McClain CJ, Price S, Barve S, Devalarja R, & Shedlofsky S. (1999). Acetaminophen hepatotoxicity: An update. Current gastroenterology reports, 10980926.
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