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Published on: 2/23/2026

Is It Adenomyosis? Why Your Uterus Is Inflamed & Medical Next Steps

Adenomyosis is a common reason a uterus appears enlarged or inflamed, caused by endometrial tissue growing into the uterine muscle and triggering bleeding within the wall that leads to heavy, painful periods, pelvic pressure, and sometimes anemia or fertility challenges. Diagnosis relies on history, exam, and imaging such as transvaginal ultrasound or MRI, and treatment ranges from NSAIDs and hormonal options including a hormonal IUD to procedures like uterine artery embolization, ablation, or hysterectomy based on symptoms and pregnancy goals. There are several factors to consider, including red flags and which option fits you best, so see the complete details below to guide your next medical steps.

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Explanation

Is It Adenomyosis? Why Your Uterus Is Inflamed & Medical Next Steps

If you've been told your uterus looks "bulky," "enlarged," or "inflamed," or you're dealing with heavy, painful periods that seem to be getting worse with age, you may be wondering: Is it adenomyosis?

Adenomyosis is a common but often misunderstood condition. It can significantly affect quality of life, yet many women go years without a clear diagnosis. Understanding what adenomyosis is, what symptoms to watch for, and what to do next can help you take informed, confident steps toward better health.


What Is Adenomyosis?

Adenomyosis happens when tissue that normally lines the inside of the uterus (the endometrium) grows into the muscular wall of the uterus (the myometrium).

Each month, this misplaced tissue thickens, breaks down, and bleeds—just like regular uterine lining. But because it's trapped within the muscle wall, it can cause:

  • Inflammation
  • Swelling
  • Uterine enlargement
  • Significant pain

Over time, the uterus may become enlarged and tender. Some women describe it as feeling "heavy" or "full" in the lower abdomen.

Adenomyosis is not cancer, but it can be painful and disruptive.


Why Does Adenomyosis Cause an Inflamed Uterus?

The inflammation comes from repeated monthly bleeding inside the uterine muscle. Unlike normal menstrual blood, this blood cannot exit the body easily. The result can be:

  • Thickened uterine walls
  • Swelling and pressure
  • Increased sensitivity to pain
  • Stronger, more painful contractions during periods

The condition often worsens during the reproductive years because it is influenced by estrogen. Symptoms may improve after menopause when hormone levels decline.


Common Symptoms of Adenomyosis

Symptoms vary. Some women have mild issues. Others experience severe pain and heavy bleeding.

Common signs include:

  • Heavy or prolonged menstrual bleeding
  • Severe menstrual cramps
  • Chronic pelvic pain
  • Pain during sex
  • Passing large blood clots
  • A feeling of pelvic pressure or fullness
  • An enlarged or tender uterus on exam
  • Fatigue from anemia caused by heavy bleeding

If your periods have become heavier or more painful in your 30s or 40s, adenomyosis may be worth discussing with your doctor.


Who Is at Higher Risk?

Adenomyosis is more common in:

  • Women aged 35–50
  • Those who have had children
  • Women with prior uterine surgery (such as C-sections or fibroid removal)
  • Those with endometriosis (the two conditions can occur together)

However, younger women can develop adenomyosis too.


Adenomyosis vs. Other Conditions

Symptoms of adenomyosis overlap with several other gynecological conditions. It is often mistaken for:

  • Fibroids
  • Endometriosis
  • Hormonal imbalances
  • Pelvic inflammatory conditions

The key difference is where the abnormal tissue is located. In adenomyosis, the tissue is embedded in the uterine muscle wall. In endometriosis, similar tissue grows outside the uterus.

Because symptoms overlap, imaging is often needed for a clearer diagnosis.


How Is Adenomyosis Diagnosed?

There is no single blood test for adenomyosis.

Doctors typically diagnose it through:

1. Medical History

Your doctor will ask about:

  • Bleeding patterns
  • Pain severity
  • Duration of symptoms
  • Prior pregnancies or surgeries

2. Pelvic Exam

The uterus may feel enlarged, soft, or tender.

3. Imaging Tests

  • Transvaginal ultrasound – Often the first step
  • MRI – More detailed and can confirm findings

In the past, adenomyosis was only definitively diagnosed after hysterectomy. Today, imaging technology allows for much earlier and less invasive detection.

If you're unsure whether your symptoms align with this condition, using a free AI-powered Adenomyosis symptom checker can help you assess your risk and prepare informed questions before your doctor's appointment.


Is Adenomyosis Dangerous?

Adenomyosis is not life-threatening. However, it can become serious if:

  • Heavy bleeding causes anemia
  • Pain interferes with daily life
  • Fertility becomes affected
  • Mental health suffers due to chronic discomfort

Ignoring severe symptoms is not recommended. Heavy bleeding that soaks through pads or tampons hourly, severe pelvic pain, or signs of anemia (fatigue, dizziness, shortness of breath) should prompt medical attention.


Medical Treatment Options

Treatment depends on:

  • Symptom severity
  • Age
  • Desire for future pregnancy
  • Overall health

1. Pain Management

For mild cases:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce cramps and inflammation.

2. Hormonal Treatments

Hormonal therapy aims to reduce bleeding and suppress abnormal tissue growth.

Options include:

  • Birth control pills
  • Hormonal IUD (often very effective for heavy bleeding)
  • Progesterone therapy
  • GnRH analogs (used short-term in more severe cases)

These treatments can reduce symptoms but do not permanently cure adenomyosis.

3. Uterine Artery Embolization (UAE)

This minimally invasive procedure reduces blood supply to affected tissue. It may improve symptoms in some women but is not suitable for everyone.

4. Endometrial Ablation

This procedure removes or destroys the uterine lining. It may reduce bleeding but is often less effective if adenomyosis extends deeply into the muscle.

5. Hysterectomy

Surgical removal of the uterus is the only definitive cure for adenomyosis.

It is typically considered when:

  • Symptoms are severe
  • Other treatments fail
  • Childbearing is complete

While effective, hysterectomy is major surgery and requires careful discussion with a gynecologist.


Can Adenomyosis Affect Fertility?

The relationship between adenomyosis and fertility is still being studied.

Some women conceive without difficulty. Others may experience:

  • Difficulty implanting embryos
  • Increased miscarriage risk
  • Coexisting endometriosis (which can impact fertility)

If you are trying to conceive and suspect adenomyosis, speak with a reproductive specialist early.


When Should You Speak to a Doctor?

Make an appointment if you experience:

  • Very heavy periods (soaking protection every hour)
  • Severe cramps that disrupt work or school
  • Pelvic pain outside your period
  • Symptoms of anemia
  • Sudden worsening of menstrual symptoms

Seek urgent care if you have:

  • Fainting
  • Severe, sudden abdominal pain
  • Signs of significant blood loss

While adenomyosis itself is not cancer, other serious conditions can cause similar symptoms. Always speak to a doctor about symptoms that could be serious or life threatening.


Living With Adenomyosis

If diagnosed, remember:

  • You are not alone.
  • Effective treatments are available.
  • Many women manage symptoms successfully.

Lifestyle adjustments that may help include:

  • Tracking your cycle
  • Iron supplementation (if recommended by your doctor)
  • Regular gentle exercise
  • Stress management techniques

Pain and heavy bleeding are not something you have to "just live with."


The Bottom Line

Adenomyosis is a common cause of an inflamed, enlarged uterus and heavy, painful periods. It happens when uterine lining tissue grows into the muscular wall of the uterus, leading to swelling and chronic inflammation.

While not life-threatening, it can significantly affect daily life. The good news is that modern imaging makes diagnosis easier than ever, and multiple treatment options exist—from hormonal therapies to surgical solutions.

If your periods are getting worse instead of better, trust your instincts. Take a few minutes to use this free AI-powered Adenomyosis symptom checker to better understand what you're experiencing, then bring those insights to your doctor. Most importantly, speak to a healthcare professional about any persistent, severe, or concerning symptoms.

You deserve answers—and relief.

(References)

  • * Chapron C, et al. Adenomyosis: A Systematic Review of Diagnosis and Interventions. Front Surg. 2020 Jul 15;7:47. doi: 10.3389/fsurg.2020.00047. PMID: 32766329.

  • * Struble J, et al. Adenomyosis: An Update on Diagnosis and Treatment. J Clin Med. 2023 Apr 1;12(7):2680. doi: 10.3390/jcm12072680. PMID: 37049877.

  • * Zervoudis S, et al. Adenomyosis and chronic pelvic pain: a comprehensive review. J Clin Med. 2023 Jan 3;12(1):326. doi: 10.3390/jcm12010326. PMID: 36615174.

  • * Guo Y, et al. The Role of Inflammation in Adenomyosis Pathogenesis. Front Immunol. 2021 Sep 1;12:735773. doi: 10.3389/fimmu.2021.735773. PMID: 34539851.

  • * Maia H, et al. Management of adenomyosis: current medical and surgical options. Arch Gynecol Obstet. 2022 Jul;306(1):1-14. doi: 10.1007/s00404-022-06484-z. PMID: 35332309.

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