Published on: 5/6/2025
Late-onset hypogonadism usually shows symptoms in middle-aged and older men, often beginning around the age of 40.
Late-onset hypogonadism is a condition where testosterone levels naturally fall as a man gets older. Many men start noticing the signs in their 40s to 50s. During this time, a man’s body slowly makes less testosterone, which can affect energy levels, mood, muscle strength, and sexual function. Research shows that these changes are part of the normal aging process, but for some men, the decrease in testosterone is enough to cause noticeable symptoms that interfere with daily life. While the typical age is around 40 and older, the exact timing and intensity of symptoms can vary from one person to another. It is important to remember that every man is unique and some may not have noticeable problems until later. If anyone experiences symptoms or concerns, it is a good idea to speak with a healthcare provider to discuss what is normal for aging and what may need further evaluation.
(References)
Nieschlag E. Late-onset hypogonadism: a concept comes of age. Andrology. 2020 Nov;8(6):1506-1511. doi: 10.1111/andr.12719. Epub 2019 Nov 15. PMID: 31639279.
Dudek P, Kozakowski J, Zgliczyński W. Late-onset hypogonadism. Prz Menopauzalny. 2017 Jun;16(2):66-69. doi: 10.5114/pm.2017.68595. Epub 2017 Jun 30. PMID: 28721133; PMCID: PMC5509975.
Isidori AM, Aversa A, Calogero A, Ferlin A, Francavilla S, Lanfranco F, Pivonello R, Rochira V, Corona G, Maggi M. Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE). J Endocrinol Invest. 2022 Dec;45(12):2385-2403. doi: 10.1007/s40618-022-01859-7. Epub 2022 Aug 26. PMID: 36018454; PMCID: PMC9415259.
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