Our Services
Medical Information
Helpful Resources
Published on: 2/24/2026
High cortisol often stems from chronic stress, poor sleep, blood sugar swings, steroid medicines, or endocrine disorders like Cushing’s, and can show up as fatigue with insomnia, abdominal weight gain, high blood pressure or sugar, mood changes, and frequent infections.
There are several factors to consider; medical steps include timed blood, saliva, or 24-hour urine testing, treating root causes, improving sleep, stabilizing blood sugar, right-sized exercise, evidence-based stress therapies, weight management, and limiting alcohol and nicotine. See below for red flags, nuances about thyroid and adrenal fatigue, and detailed guidance that could change your next steps.
If you feel constantly "on edge," wired but tired, or unable to relax, you may have wondered whether your cortisol levels are too high. Cortisol is often called the "stress hormone," but it does far more than respond to pressure. It plays a vital role in your metabolism, immune system, blood pressure, sleep-wake cycle, and even memory.
When cortisol stays elevated for too long, it can affect nearly every system in your body. The good news? High cortisol is usually manageable once you understand the cause.
Below, we'll explain what cortisol does, why it may be high, how doctors evaluate it, and evidence-based medical steps that can help restore balance.
Cortisol is a hormone made by your adrenal glands, which sit on top of your kidneys. It is controlled by the brain through the hypothalamic-pituitary-adrenal (HPA) axis.
Your body naturally releases cortisol:
Short-term increases in cortisol are normal and helpful. Problems arise when cortisol remains chronically elevated.
Persistently high cortisol levels can cause a range of symptoms. Not everyone experiences all of them, but common signs include:
It's important to note that these symptoms are common and not specific to high cortisol alone. Other conditions—such as thyroid disorders—can overlap. If you're experiencing unexplained fatigue, neck pain, or fever along with these symptoms, it's worth checking whether Subacute Thyroiditis could be behind your discomfort, as this thyroid inflammation can mimic stress-related symptoms.
There are several possible reasons cortisol levels become elevated. These range from lifestyle stress to medical conditions.
Ongoing work stress, caregiving responsibilities, financial strain, or poor sleep can keep your HPA axis activated. Over time, this may lead to persistently higher cortisol patterns.
Sleep and cortisol are tightly connected. Inadequate or irregular sleep can:
Shift workers and people with insomnia are especially at risk.
In some cases, high cortisol is caused by a medical disorder.
This is a condition where the body produces too much cortisol. It may result from:
Symptoms often include:
Cushing's syndrome requires medical diagnosis and treatment.
Prednisone and other corticosteroids are commonly prescribed for:
These medications can raise cortisol levels and cause similar side effects when used long term.
Frequent spikes and crashes in blood sugar can stimulate cortisol release. This is especially common in:
An overactive or inflamed thyroid can mimic high cortisol symptoms. That's why evaluating thyroid function is often part of a comprehensive assessment.
If high cortisol is suspected, your doctor may recommend:
Timing matters. Cortisol follows a daily rhythm, so testing at the wrong time can be misleading.
If you have symptoms like severe high blood pressure, unexplained muscle weakness, rapid weight gain, or purple stretch marks, speak to a doctor promptly. These can signal a more serious underlying condition.
Treatment depends on the cause. Here are evidence-based approaches:
If a condition like Cushing's syndrome or a tumor is identified, treatment may include:
If steroids are the cause, your doctor may carefully taper the medication (never stop steroids suddenly without medical supervision).
Restoring healthy sleep patterns is one of the most powerful ways to regulate cortisol.
Evidence-based steps include:
Even modest improvements in sleep can normalize cortisol rhythms over time.
Balanced blood sugar reduces unnecessary cortisol spikes.
Focus on:
Regular meals (not skipping breakfast) may also help stabilize cortisol levels.
Exercise lowers stress and improves cortisol regulation—but excessive high-intensity training can temporarily raise cortisol.
Best approaches:
Consistency matters more than intensity.
You can't eliminate stress, but you can change how your body responds to it.
Clinically supported techniques include:
Even 10–15 minutes daily can shift cortisol patterns over time.
Excess abdominal fat can increase cortisol production and sensitivity. Gradual, sustainable weight loss—if needed—can improve hormone balance.
Crash dieting, however, may raise cortisol further. Avoid extreme calorie restriction.
Both substances can elevate cortisol and disrupt sleep. Reducing intake can significantly improve hormone balance.
You may have heard of "adrenal fatigue." This term is popular online but is not recognized as a medical diagnosis by major endocrine societies. While people can feel exhausted and burned out, the adrenal glands themselves are usually functioning normally.
If symptoms are severe or persistent, it's important to evaluate for:
A proper medical workup is more effective than self-diagnosing.
Seek medical attention if you have:
These could signal a serious endocrine disorder. Speak to a doctor promptly about anything that could be life-threatening or serious.
Cortisol is not your enemy. It is essential for survival. The issue is not cortisol itself—it's chronic imbalance.
High cortisol can result from:
The good news is that most causes are treatable. By improving sleep, stabilizing blood sugar, managing stress, exercising wisely, and addressing underlying medical issues, cortisol levels often normalize.
If symptoms persist, don't ignore them. A thorough medical evaluation can identify whether cortisol is truly elevated and, more importantly, why.
You don't have to live in a constant state of stress. With the right information and medical guidance, balance is possible.
(References)
* Jankovic M, Peric M, Pavlovic S, Maric NP, Milovanovic S, Ignjatovic S. Targeting the HPA Axis in Psychiatric Disorders: From Mechanisms to Clinical Implications. Front Psychiatry. 2021 Jul 15;12:701721. doi: 10.3389/fpsyt.2021.701721. PMID: 34322079; PMCID: PMC8319692.
* Biller BMK, Findling JW, Gadelha MR, Gagliardi R, Gillam MP, Grassi G, Jørgensen JOL, Leung TH, Vance ML. The Many Faces of Hypercortisolism: Clinical and Biochemical Features, Diagnosis, and Management. Endocr Rev. 2023 Jun 20;44(3):477-505. doi: 10.1210/endrev/bnac038. PMID: 36879815.
* Deussing JM, Chen A. Glucocorticoid Receptor Antagonists for the Treatment of Psychiatric Disorders. Expert Opin Investig Drugs. 2020 Jul;29(7):727-738. doi: 10.1080/13543784.2020.1772648. Epub 2020 May 29. PMID: 32470129.
* Wu Y, Chen M. Non-Cushing's Hypercortisolism: The Diagnosis and Management. Ann Transl Med. 2021 Jun;9(12):1070. doi: 10.21037/atm-2021-36. PMID: 34277490; PMCID: PMC8263177.
* Lau N, Maric NP, Pavlovic S, Maric NP. Pharmacological Interventions for Stress-Induced Disorders: From Molecules to Behavior. Front Neurosci. 2020 Feb 4;14:26. doi: 10.3389/fnins.2020.00026. PMID: 32063854; PMCID: PMC7008711.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.