Published on: 3/5/2025
Pain in both armpits is often due to inflammation or swelling of the lymph nodes, which can result from infections, autoimmune issues, or other systemic conditions.
Both armpits contain lymph nodes, which help your body fight infections and other problems. When these lymph nodes become inflamed or swollen, they can cause pain in the armpits on both sides. This inflammation can happen due to infections like common viruses or bacteria, which make the nodes tender as they work to protect you. In some cases, systemic conditions such as mixed connective tissue disease or psoriatic arthropathy (a type of joint and skin condition) can lead to bilateral (both sides) lymphadenopathy. In such autoimmune or inflammatory conditions, your body's immune response is more active, which can cause tenderness and discomfort in the lymph nodes. Other causes might include skin infections or irritation from deodorants or shaving, though these are typically milder. If you notice persistent pain in both armpits, especially if it comes with other symptoms like fever, unexpected weight loss, or widespread swelling, it is a good idea to see a healthcare provider. They can perform an examination and any necessary tests to determine the exact cause and help you feel better.
(References)
Hammond AM, Marion T, Carstens S, Saikaly SK. Bilateral, tender axillary nodules. JAAD Case Rep. 2022 Jul 6;27:49-51. doi: 10.1016/j.jdcr.2022.06.034. PMID: 36017193; PMCID: PMC9396251.
Giambersio E, Magni V, Sardanelli F. Bilateral lymphadenopathies on mammograms: a case of mixed connective tissue disease and psoriatic arthropathy. BJR Case Rep. 2023 Jan 23;9(2):20220077. doi: 10.1259/bjrcr.20220077. PMID: 36998332; PMCID: PMC10043603.
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