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Published on: 7/15/2026

What are the causes if the base of the thumb on the palm side is painful?

Pain at the base of the thumb on the palm side is often caused by conditions such as osteoarthritis, De Quervain's tenosynovitis, carpal tunnel syndrome, thumb sprains, or repetitive strain injuries. Common symptoms include swelling, stiffness, weakness when gripping, and tenderness when pressing the area. Because these conditions share overlapping symptoms, pinpointing the exact cause is essential for choosing the right treatment—whether that's rest, splinting, physical therapy, or medical evaluation.

Since thumb pain can stem from many possible causes, guessing can delay relief and lead to worsening symptoms. Take a free, instant, online symptom check to better understand what may be causing your pain and get clear guidance on your next steps.

Reviewed for medical accuracy: 07/14/2026

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Explanation

Osteoarthritis:

One of the most common causes of pain at the base of the thumb is osteoarthritis. This degenerative joint disease occurs when the cartilage that cushions the joints wears down over time. As a result, the bones may rub against each other, leading to pain, swelling, and stiffness, particularly during activities that involve gripping or pinching.

Tendonitis:

Tendonitis, specifically de Quervain's tenosynovitis, is another potential cause of pain at the base of the thumb. This condition involves inflammation of the tendons that control thumb movement, leading to pain on the thumb side of the wrist and at the base of the thumb. Symptoms often worsen with activities that require repetitive thumb motion, such as texting or using a smartphone.

Injuries:

Injuries to the thumb, such as sprains or fractures, can also result in pain at the base. A sprain occurs when the ligaments that support the joint are stretched or torn, while a fracture involves a break in the bone. Both conditions can cause significant pain, swelling, and difficulty moving the thumb.

Ligament Injuries:

Injuries to the ligaments at the base of the thumb, such as a gamekeeper's thumb (also known as skier's thumb), can lead to pain and instability in the joint. This injury typically occurs when the thumb is forcibly bent backward, causing damage to the ulnar collateral ligament.

Other Conditions:

Other conditions, such as rheumatoid arthritis or gout, can also cause pain at the base of the thumb. Rheumatoid arthritis is an autoimmune condition that leads to joint inflammation, while gout is caused by the buildup of uric acid crystals in the joints, leading to sudden and severe pain. If you're experiencing persistent thumb pain and want to understand what might be causing it, try this free symptom checker to get personalized insights about your condition.

(References)

  • Kretschmer F. Zur Differentialdiagnose des Schmerzes an der Daumenbasis [Differential diagnosis of pain of the base of the thumb]. Beitr Orthop Traumatol. 1987 Nov;34(11):553-8. German. PMID: 3440015.

  • Shmerling RH. Finger pain. Prim Care. 1988 Dec;15(4):751-66. PMID: 3068693.

  • Brulhart L, Gabay C. Diagnostic différentiel des ténosynovites [The differential diagnosis of tenosynovitis]. Rev Med Suisse. 2011 Mar 16;7(286):587-8, 590, 592-3. French. PMID: 21510342.

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