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Knee does not move
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Congenital genu varum
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Wear and tear of the joint cartilage over time. Risk factors include repetitive joint movements and carrying heavy loads for many years.
Your doctor may ask these questions to check for this disease:
Osteoarthritis cannot be reversed, but treatment can improve its symptoms. Mild cases can be managed with lifestyle changes like losing weight, using walking aids, and warm compresses. Painkillers and medicine to reduce inflammation can help with joint pain - these can sometimes be injected directly into the joint. In severe cases, surgery to smooth the bone surface or replace it with an implant can be done.
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Tomohiro Hamahata, MD (Orthopedics)
Dr. Hamahata graduated from the Jikei University of Medical Science. After working at Asanokawa General Hospital and Kosei Chuo Hospital, he joined the Department of Orthopedics at Asakusa Hospital in April 2021, specializing in general orthopedics and joint replacement surgery.
Content updated on Feb 13, 2025
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Q.
Taking Hyaluronic Acid for Joint Pain? The Evidence and Next Steps
A.
Hyaluronic acid can provide modest, gradual relief for joint pain in mild to moderate osteoarthritis, with oral supplements generally low risk and injections showing stronger but variable benefits for knees; it is not a cure. There are several factors to consider, including who benefits most, how long to try it, safety cautions, and how to combine it with proven treatments like exercise, weight management, and physical therapy. See below for complete details, next steps, when to stop, and red flags that mean you should see a doctor.
References:
* Huang S, Zhang X, Li Z, et al. Hyaluronic acid for knee osteoarthritis: an updated meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2024 Feb 24;25(1):159. doi: 10.1186/s12891-024-07233-1. PMID: 38396001; PMCID: PMC10890695.
* Bannuru RR, Flavin OP, Vaysbrot E, et al. Efficacy and Safety of Intra-articular Hyaluronic Acid for Knee Osteoarthritis: An Updated Systematic Review and Meta-Analysis. Arthritis Rheumatol. 2022 Dec;74(12):1913-1925. doi: 10.1002/art.42291. Epub 2022 Sep 27. PMID: 35920360.
* Œhme P, Bohnert J. Oral hyaluronic acid in the treatment of osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2022 Dec;30(12):1567-1579. doi: 10.1016/j.joca.2022.10.003. Epub 2022 Oct 25. PMID: 36306915.
* Wong M, Sun Y, Chen Y, et al. Efficacy and safety of intra-articular hyaluronic acid for hip osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2023 Mar 28;18(1):173. doi: 10.1186/s13018-023-03657-z. PMID: 36978018; PMCID: PMC10052382.
* Kon E, Ronga M, Marmotti A, et al. The efficacy of intra-articular hyaluronic acid in patients with knee osteoarthritis: a systematic review and meta-analysis. Arthroscopy. 2020 Aug;36(8):2167-2178. doi: 10.1016/j.arthro.2020.03.018. Epub 2020 Jun 1. PMID: 32487498.
Q.
How Much Turmeric Should You Take for Joint Pain? A Doctor’s Guide
A.
Most adults see benefit with 500 to 1,000 mg of standardized curcumin extract per day, split into two doses for 8 to 12 weeks, ideally in a formula with piperine for absorption; some osteoarthritis trials use 1,000 to 1,500 mg under medical supervision, and culinary turmeric alone is usually insufficient despite pairing with black pepper and fat. There are several factors to consider. See below to understand more, including interactions with blood thinners, gallbladder or kidney stone history, pregnancy, potential side effects, product quality, when to seek medical care, and that turmeric is not a replacement for prescribed treatment.
References:
* Kuptniratsaikul V, Thanatporn K, Rattanachaiwong S, et al. Efficacy and safety of curcumin in the management of osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. J Ethnopharmacol. 2019 Nov 15;244:112165. doi: 10.1016/j.jep.2019.112165. Epub 2019 Aug 6. PMID: 31388301.
* Han F, Ding Y, Cao Y, Xu Y. Efficacy and Safety of Curcuma longa Extract in the Treatment of Pain and Functional Impairment Associated with Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Pain Res Manag. 2023 Aug 24;2023:7147983. doi: 10.1155/2023/7147983. PMID: 37626359; PMCID: PMC10471295.
* Mirzaei H, Gupta P, Masoud H, et al. Role of Curcuma longa and Curcumin in the Management of Pain. Biomolecules. 2022 Nov 4;12(11):1615. doi: 10.3390/biom12111615. PMID: 36369062; PMCID: PMC9687446.
* Wang Z, Jones G, Winzenberg T, et al. Curcumin for the treatment of osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2016 Sep;75(9):1636-40. doi: 10.1136/annrheum-2015-208226. Epub 2016 Apr 4. PMID: 27042304.
* Zeng L, Yang T, Yang K, et al. The effect of curcumin in patients with osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. J Tradit Chin Med. 2016 Oct;36(5):611-618. doi: 10.1016/S0254-6272(16)30113-1. PMID: 27721200.
Q.
Joint Pain Won't Stop? Glucosamine Chondroitin Truth & Medically Approved Next Steps
A.
Glucosamine chondroitin can offer mild pain relief for some people, mainly with moderate knee osteoarthritis, but results are mixed and it does not rebuild cartilage; a 2 to 3 month trial is reasonable only if it is safe for you. More effective, medically supported steps include strength training and low impact exercise, weight management, topical NSAIDs before pills, cautious use of oral pain relievers, and considering injections or surgery when conservative care fails, with urgent evaluation for red flag symptoms. There are several factors to consider, including dosing, who benefits, safety exceptions, other causes of joint pain, and when to seek care; see the complete details below to choose the right next steps.
References:
* Singh OA, Al-Nuaimi M, Mula J, Kumar S. Glucosamine and chondroitin in the management of osteoarthritis: an updated systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology (Oxford). 2021 May 26;60(5):2075-2086. doi: 10.1093/rheumatology/keaa835. PMID: 33367876.
* Block JA, Brandt KD, Vivar J, Goker B, Ozgonenel L, Peloso PM, Rosner AJ. Safety of glucosamine, chondroitin, and their combination in people with osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2020 Jan;28(1):16-29. doi: 10.1016/j.joca.2019.09.006. Epub 2019 Oct 1. PMID: 31539655.
* Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt K, Block J, Bramoweth D, Carey-Butler L, Dasa G, Freire M, Harkless L, Keenan MA, Klohr J, Major G, Moreland LW, Mezhov V, Morgan H, Morris B, Samuels J, Scanzello A, White D, Wise B, Wright J, Reston J. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-162. doi: 10.1002/acr.24131. Epub 2020 Jan 14. PMID: 31908152.
* Bartholdy C, Juhl CB, Christensen R, Bandak E, Henriksen M. Exercise for osteoarthritis of the knee: a systematic review and meta-analysis. Semin Arthritis Rheum. 2021 Apr;51(2):292-300. doi: 10.1016/j.semarthrit.2020.10.007. Epub 2020 Oct 21. PMID: 33130282.
* Martel-Pelletier J, Pelletier JP, Abram F. Pharmacological management of osteoarthritis: current approaches and future directions. Expert Opin Pharmacother. 2021 Jan;22(1):13-26. doi: 10.1080/14656566.2020.1804928. Epub 2020 Aug 26. PMID: 32772520.
Q.
Is it Time for a Knee Replacement? Why Your Joint is Failing and Medical Next Steps
A.
There are several factors to consider. See below to understand more. Knees most often fail from osteoarthritis that erodes cartilage, and when pain, stiffness, swelling, and loss of function persist despite physical therapy, weight loss, medications or injections, and imaging shows severe damage, it is time to discuss total or partial knee replacement with an orthopedic surgeon; the full guide below details candidacy, risks, recovery timelines, non-surgical alternatives, and urgent red flags that could change your next steps.
References:
* Hunter DJ, Bierma-Zeinstra SMA. Osteoarthritis. Lancet. 2019 Apr 27;393(10182):1745-1759. doi: 10.1016/S0140-6736(19)30417-9. Epub 2019 Mar 25. PMID: 30917916.
* Kolasinski SL, Neogi T, Oatis CA, American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020 Feb;72(2):220-233. doi: 10.1002/art.41142. PMID: 31951509.
* Ackerman IN, Prokop LL, Brown EN, et al. Shared Decision-Making in Total Knee Arthroplasty. J Arthroplasty. 2017 Jul;32(7):2028-2032. doi: 10.1016/j.arth.2017.02.040. Epub 2017 Mar 4. PMID: 28389146.
* Pincus D, Ravi B, Wasserstein D, et al. Association Between Surgical Delay and Clinical Outcomes in Patients With Knee Osteoarthritis. JAMA Surg. 2018 Apr 1;153(4):307-313. doi: 10.1001/jamasurg.2017.4721. PMID: 29280036.
* Clemente A, Cugno C, Ribero C, et al. Predicting the Outcome of Total Knee Arthroplasty for Osteoarthritis: A Systematic Review. J Arthroplasty. 2020 Jan;35(1):241-249.e1. doi: 10.1016/j.arth.2019.08.018. Epub 2019 Sep 18. PMID: 31543360.
Q.
Persistent Joint Pain? Why Hyaline Cartilage Fails & Medically Approved Next Steps
A.
Persistent joint pain often stems from hyaline cartilage breakdown that cushions joints, most commonly from osteoarthritis but also from injury, overuse, aging, or inflammatory disease, and it heals poorly without early care. Medically approved next steps include getting a proper diagnosis (exam, X-ray or MRI), then evidence-based treatments like weight management, physical therapy, appropriate medications, targeted injections, and in select cases regenerative procedures or joint replacement; there are several factors to consider, so see the complete details below to guide which options fit your situation and when to seek urgent care.
References:
* Abramoff B, Caldera FE. Osteoarthritis. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507884/
* Liu S, Geng C, Zhang W, Wang W, Lin J, Li Z, Huang X, Wang Z. Recent Advances in Understanding the Molecular Mechanisms of Osteoarthritis. Int J Mol Sci. 2022 Jul 26;23(15):8227. doi: 10.3390/ijms23158227. PMID: 35897464; PMCID: PMC9368551.
* Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt J, Block J, Callahan L, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020 Feb;72(2):220-233. doi: 10.1002/art.41172. Epub 2020 Jan 21. PMID: 31969062.
* Kon E, Roffi A, Tesei G, D'Ambrosi R, Berruto M, Denti M, Marcacci M. Current Surgical Strategies for Cartilage Repair. J Clin Med. 2021 Mar 18;10(6):1244. doi: 10.3390/jcm10061244. PMID: 33800683; PMCID: PMC8003666.
* Ghouri A, D'Ambrosi R, Kon E. Emerging Treatments for Osteoarthritis. J Clin Med. 2023 Feb 24;12(5):1848. doi: 10.3390/jcm12051848. PMID: 36902781; PMCID: PMC10003058.
Q.
Sharp Joint Pain? Why Bone Spurs Form & Your Medical Next Steps
A.
Bone spurs are smooth extra bone growths that often form from osteoarthritis, aging, or repetitive stress and, while common, can trigger sharp pain, stiffness, or nerve symptoms that may need imaging and targeted care. There are several factors to consider; see below to understand more, including when conservative care like activity changes, physical therapy, and anti-inflammatories is enough versus when persistent pain, numbness, weakness, severe swelling, or bladder or bowel changes call for prompt medical evaluation.
References:
* van der Kraan, P. M., & van den Berg, W. B. (2010). Osteophyte formation in osteoarthritis: what is the current understanding? *Nature Reviews Rheumatology*, *6*(9), 513–518.
* Jiang, Z., Cai, B., Li, X., Wang, Y., Gao, S., Lu, C., ... & Xu, J. (2023). Osteophyte: a comprehensive review of its characteristics, pathogenesis, and clinical implications. *Annals of the Rheumatic Diseases*.
* Hunter, D. J., & Bierma-Zeinstra, S. (2015). Osteoarthritis. *The Lancet*, *386*(9991), 172–181.
* Petersen, M. J., Møller, C., Thorlund, J. B., & Overgaard, S. (2020). Interventions for pain in the ankle and foot due to osteoarthritis. *Cochrane Database of Systematic Reviews*, (3).
* Mahendran, P., Singh, S., & Conaghan, P. G. (2020). Clinical assessment of osteophytes in the hands: a systematic literature review. *Osteoarthritis and Cartilage*, *28*(7), 843–851.
Q.
Is It Bone on Bone? Why Your Cartilage Is Failing & Medically Approved Next Steps
A.
“Bone on bone” usually means advanced cartilage loss, most often from osteoarthritis, causing pain, stiffness, and reduced function, even though X-ray severity does not always match symptoms. Evidence-based next steps start with proper evaluation, then conservative care like weight management, physical therapy, low impact activity, medications or injections, and bracing, with joint replacement if these fail and urgent care for sudden swelling with fever or inability to bear weight. There are several factors to consider that can change your best path; see below for the complete answer and important details.
References:
* Lohmander LS, Roos EM. Articular Cartilage Failure: Current Concepts in Etiology, Diagnosis, and Management. Curr Rheumatol Rep. 2018 Jan 25;20(2):8. doi: 10.1007/s11926-018-0713-3. PMID: 29370395.
* Litwic A, Kapica-Topczewska K, Fiedorowicz K, Charkiewicz AE, Sawicka J, Tarasiuk J, Łebkowski W, Ładny JR. Pathophysiology of Osteoarthritis: An Update. Biomedicines. 2020 Sep 3;8(9):310. doi: 10.3390/biomedicines8090310. PMID: 32899450; PMCID: PMC7551061.
* Bannuru RR, Osani MC, Vaysbursd M, Avery L, Rowland M, McGinn T, Devine PJ, Goodman SM. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-1589. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 10. PMID: 31302174.
* Kolasinski SL, Neogi T, O'Dell JR, Remmers N, Turgunbaev M, Kretzmann L. Diagnosis and Management of Osteoarthritis of the Knee. Am Fam Physician. 2021 Jan 15;103(2):90-99. PMID: 33443831.
* D'Ambrosi R, Cella V, De Luca C, Ursino N, Zagra L. Current Surgical Options for the Treatment of Cartilage Lesions of the Knee. J Clin Med. 2022 Mar 22;11(6):1716. doi: 10.3390/jcm11061716. PMID: 35330107; PMCID: PMC8956972.
Q.
Joint Pain? Diclofenac Sodium Topical Gel: Medically Approved Next Steps
A.
Diclofenac sodium topical gel is a medically recommended first-line option for mild to moderate localized joint pain, especially knee and hand osteoarthritis. It works at the site to reduce inflammation with generally fewer whole body risks than oral NSAIDs, and consistent use for up to 1 to 2 weeks is often needed to see full benefit. There are several factors to consider, including who should avoid it, correct dosing and safety steps, possible side effects and red flags, and what to try next if pain persists; see below for complete details and medically approved next steps.
References:
* Singh D, Alsayed R, Agrawal N. Topical diclofenac sodium gel for osteoarthritis. Cochrane Database Syst Rev. 2021 Apr 22;4(4):CD010839. doi: 10.1002/14651858.CD010839.pub2. PMID: 33887034.
* Kolasinski SL, Neogi NM, Newman LM, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-162. doi: 10.1002/acr.24102. PMID: 31908149.
* Zempsky WT, Kay J, Koh J. Diclofenac Sodium Topical Gel for Acute Pain: A Review. Clin J Pain. 2017 Jan;33(1):86-92. doi: 10.1097/AJP.0000000000000350. PMID: 27145716.
* Baraf HS, Gloth FM, Felson DT, et al. Diclofenac sodium 1% gel provides both pain relief and functional improvement in patients with knee osteoarthritis: a pooled analysis. Pain Pract. 2011 Nov-Dec;11(6):579-91. doi: 10.1111/j.1533-2500.2011.00483.x. PMID: 22004245.
* Simon LS, Grierson LM, Nash P, et al. The efficacy and safety of topical diclofenac gel for the treatment of primary osteoarthritis of the knee: a randomized, double-blind, multicenter, placebo-controlled trial. J Rheumatol. 2009 Dec;36(12):2708-15. doi: 10.3899/jrheum.090403. PMID: 19875881.
Q.
Knee Pain? Why Your Knee Hurts: Patellofemoral Pain Syndrome Medical Steps
A.
Patellofemoral pain syndrome is a common cause of pain in the front of the knee around or behind the kneecap, usually from overuse, muscle imbalance, or poor tracking, and it typically improves with nonsurgical care. Key medical steps include activity modification, targeted hip and quadriceps strengthening with physical therapy, flexibility work, ice and short term NSAIDs, possible taping or bracing, supportive footwear or orthotics, and a gradual return to activity, with surgery rarely needed; seek urgent care for severe swelling, inability to bear weight, fever, locking, or deformity, and expect recovery in about 6 to 12 weeks if you stick with rehab. There are several factors to consider, including whether arthritis might be contributing; see the complete details below to guide your specific next steps.
References:
* Maclachlan L, Thornton R, Allison K, Crossley K, Vicenzino B. Patellofemoral Pain Syndrome: An Umbrella Review of Systematic Reviews. Sports Med. 2023 Feb;53(2):495-512. doi: 10.1007/s40279-022-01799-6. Epub 2022 Dec 16. PMID: 36520330.
* Lathian V, Stoker J, Goudie PW, Vicenzino B, Crossley KM. Patellofemoral pain syndrome: A comprehensive review on prevalence, etiology, risk factors, diagnosis, and management. Clin Sports Med. 2023 Jul;42(3):399-420. doi: 10.1016/j.csm.2023.01.002. Epub 2023 Feb 15. PMID: 37270271.
* Crossley KM, Barton CJ, Lack S, Malliaras P, Morrissey D, Callaghan MJ, Vicenzino B. 2021 Patellofemoral Pain Clinical Practice Guidelines: An International Consensus. J Orthop Sports Phys Ther. 2021 Sep;51(9):CPG1-CPG80. doi: 10.2519/jospt.2021.0305. Epub 2021 Aug 31. PMID: 34469778.
* Barton CJ, Maclachlan L, Vicenzino B, Crossley KM, Morrissey D, Lack S, Macleod A. Exercise for patellofemoral pain: An umbrella review. Br J Sports Med. 2022 May;56(9):496-503. doi: 10.1136/bjsports-2021-104998. Epub 2022 Feb 7. PMID: 35131885.
* Lack S, Barton CJ, Vicenzino B, Morrissey D, Crossley KM. Patellofemoral Pain Syndrome: An Updated Review of Evidence-Based Physical Therapy. J Orthop Sports Phys Ther. 2021 Aug;51(8):385-397. doi: 10.2519/jospt.2021.10162. Epub 2021 Jul 29. PMID: 34332402.
Q.
Joint Pain? Why Curcumin Fails + Medically Approved Next Steps
A.
Curcumin often provides only mild relief and frequently fails because of poor absorption, inconsistent dosing or quality, the wrong diagnosis, advanced structural damage, or unaddressed mechanical stress; there are several factors to consider. See the complete explanation below. Evidence-based next steps include strength training and physical therapy, weight management, topical or oral NSAIDs when appropriate, selective injections, and early rheumatology evaluation for inflammatory signs, with urgent care for red-flag symptoms. Key details that can change your personal plan are outlined below.
References:
* Hewlings, S. J., & Kalman, D. S. (2017). The challenge of curcumin bioavailability: An overview. *Journal of nutrition and metabolism*, *2017*. [PMID: 29062327]
* Kotha, R. R., & Luthra, N. P. (2018). Curcumin: an overview of pharmacological activities and its effect in clinical trials. *Journal of Clinical Pharmacology*, *58*(5), 523-547. [PMID: 29334571]
* Cameron, M., & Chrubasik, S. (2015). Herbal medicine for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. *Journal of Clinical Rheumatology*, *21*(6), 295-307. [PMID: 26270830]
* Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, K., Guyatt, G., Block, J., ... & Tugwell, P. (2020). 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. *Arthritis & Rheumatology*, *72*(2), 220-233. [PMID: 31920050]
* Smart, K. M., Doody, C., Furlong, B., Lehane, D., & O'Connell, N. E. (2020). Exercise for chronic musculoskeletal pain: a review of the evidence for effect and mechanisms. *Physical Therapy Reviews*, *25*(3-4), 216-231. [PMID: 32328173]
Q.
Is It EDS? Why Your Joints Are Failing & Medically Approved Next Steps
A.
Joint instability, dislocations, and chronic pain can be caused by Ehlers-Danlos syndrome, but osteoarthritis and other issues are more common; diagnosis is clinical using history, exam, Beighton score, family patterns, and exclusion of other causes. Next steps include a proper medical evaluation, strength-focused physical therapy, joint protection, appropriate pain care, screening for related conditions, and urgent attention for severe chest or abdominal pain; there are several factors to consider, and the complete guidance that could affect your choices is detailed below.
References:
* Malfait F, Francomano RL, Byers PH, Belmont J, Berglund B, Bober JM, et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):8-26. doi: 10.1002/ajmg.c.31552. Epub 2017 Jan 31. PMID: 28286927.
* Tinkle B, Castori M, Berglund B, Cohen H, Driver CC, Francomano R, et al. Hypermobile Ehlers-Danlos Syndrome (hEDS): A New Perspective. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):153-171. doi: 10.1002/ajmg.c.31558. Epub 2017 Jan 26. PMID: 28221855.
* Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):148-152. doi: 10.1002/ajmg.c.31539. Epub 2017 Jan 30. PMID: 28221855.
* Chopra P, Tinkle B, Levy H, Fahy E, Herrera-Soto A, Quigley R, et al. Pain Management in the Ehlers-Danlos Syndromes: Evolving Approaches. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):212-219. doi: 10.1002/ajmg.c.31541. Epub 2017 Jan 30. PMID: 28221849.
* Hakim AJ, De Wandele I, Eccleston C, Miller R, Tomlinson M, Veriki S, et al. Chronic pain and fatigue in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders- an evidence based approach. Br J Pain. 2021 May;15(2):162-177. doi: 10.1177/2049463720932028. Epub 2020 Jun 16. PMID: 34104271; PMCID: PMC8174526.
Q.
Shoulder Pain? Why Your Joint Is Failing & Medically Approved Next Steps
A.
Shoulder pain most often comes from arthritis, rotator cuff problems, frozen shoulder, impingement, or instability, and most cases improve without surgery using medically approved steps like gentle activity, physical therapy, targeted ice or heat, and short courses of appropriate anti-inflammatory medication, with injections or imaging only when necessary. There are several factors to consider, including urgent red flags like chest pain or a sudden deformity and the right timing for imaging, injections, or surgery; see the complete guidance below for cause-specific steps and precautions that could change your next move.
References:
* Ma, Y., Sun, X., Yu, J., Jiang, S., Li, X., Wu, G., ... & Tian, M. (2023). Progress in the diagnosis and treatment of shoulder pain. *Frontiers in Surgery*, *10*, 1162468. DOI: 10.3389/fsurg.2023.1162468. PMID: 37050519.
* Gumina, R. S., & Newman, J. S. (2021). Rotator Cuff Tears: Pathophysiology, Diagnosis, and Treatment. *Orthopedic Clinics of North America*, *52*(1), 1-13. DOI: 10.1016/j.ocl.2020.09.001. PMID: 33127265.
* Mao, K., Wang, Y., Sun, D., Liu, Z., Lu, H., & Jiang, J. (2022). Adhesive capsulitis of the shoulder: a comprehensive review. *Journal of Orthopaedic Surgery and Research*, *17*(1), 1-12. DOI: 10.1186/s13018-022-03350-0. PMID: 36384852.
* Green, S., Rombach, I., Gray, A., & Buchbinder, R. (2021). Conservative interventions for shoulder pain: an overview of Cochrane Reviews. *Cochrane Database of Systematic Reviews*, *(7)*. DOI: 10.1002/14651858.CD014873.pub2. PMID: 34293235.
* Jabbour, S., Hage, S., Dagher, J., El Achkar, M., & Aoude, M. (2023). Current concepts in the diagnosis and management of shoulder pain: a review. *Journal of Musculoskeletal Surgery and Research*, *7*(1), 1-10. DOI: 10.4103/jomsr.jomsr_110_22. PMID: 36915609.
Q.
Voltaren Not Working? Why Your Joints Are Still Inflamed and Medically Approved Next Steps
A.
If Voltaren is not easing joint inflammation, likely causes include disease progression, a wrong diagnosis like gout or autoimmune arthritis, incorrect use or dosing, inflammation too deep or severe for gel, mechanical joint damage, or lifestyle drivers. Medically approved next steps are to confirm the diagnosis, start physical therapy, discuss oral NSAIDs or injections, use DMARDs if autoimmune disease is present, and optimize weight and low impact exercise, while seeking urgent care for a red, hot, very painful joint, fever, inability to bear weight, or chest pain on NSAIDs. There are several factors to consider; see complete details below to guide the right next step for your situation.
References:
* Conaghan, P. G., et al. (2019). Why do some patients with osteoarthritis respond better to NSAIDs than others? A narrative review of factors influencing response. *Rheumatology*, *58*(Supplement_4), iv17–iv28. PMID: 31765416.
* Kim, M. J., et al. (2022). Current status and future trends of NSAID resistance in inflammatory rheumatic diseases. *Journal of Clinical Medicine*, *11*(13), 3656. PMID: 35807185.
* Lally, E. V., & Lally, L. M. (2020). Approach to the Patient with Polyarticular Joint Pain. *Medical Clinics of North America*, *104*(3), 403–415. PMID: 32326922.
* Loeser, R. F., et al. (2022). Pathophysiology and Management of Inflammation in Osteoarthritis. *Arthritis & Rheumatology*, *74*(1), 10–23. PMID: 34505877.
* Smolen, J. S., et al. (2023). EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. *Annals of the Rheumatic Diseases*, *82*(1), 3–18. PMID: 36328652.
Q.
Joint Pain? The Celebrex Reality & Medically Approved Next Steps
A.
Celebrex can reduce joint pain and stiffness about as well as other NSAIDs and is often gentler on the stomach, but it is a symptom-control tool, not a cure. There are several factors to consider, including boxed cardiovascular warnings, potential kidney and GI risks, and confirming the right diagnosis; see below for details that could change your next steps. The complete answer below covers who should use caution or avoid it, safest dosing principles, red flags needing urgent care, and evidence based alternatives like weight management, physical therapy, topical NSAIDs or capsaicin, and other medications so you can choose the right plan with your doctor.
References:
* Wang Y, Lu S, Wu H, Zhang Y, Yan S, Gu Z, Ma J. Therapeutic Efficacy and Safety of Celecoxib for Osteoarthritis. J Inflamm Res. 2021 Jun 25;14:2679-2689. doi: 10.2147/JIR.S315513. PMID: 34211100; PMCID: PMC8241285.
* Lazzaroni M, Re M, Benvenga S, Bianchi P, Breda M, De Bastiani R, Del Ponte A, Di Fabio S, Donà M, Ferrero M, Iannuzzo G, Lazzaroni L, Malorgio C, Marigo S, Rinaldi A, Salari P, Santarossa L, Testa S, Vettore F. Cardiovascular and Gastrointestinal Safety of Celecoxib: A Literature Review. J Clin Med. 2017 Oct 17;6(10):97. doi: 10.3390/jcm6100097. PMID: 29046604; PMCID: PMC5666750.
* Kolasinski SL, Neogi T, Hochberg MC, Oatis L, Bozic D, Conaghan J, Katz JN, Kloppenburg M, Mease P, Smith V, Todd G, Warren M, Reston J, Rondina J, Barlow CE, Castillo Rivera A, Dasa G, Gillispie M, Miller AS, Nowell WB, Porter RM, Sung YC, Turgay D, Whittle J, Deshpande BR, Guyatt G, McAlindon T. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020 Feb;72(2):220-233. doi: 10.1002/art.41142. Epub 2020 Jan 29. PMID: 30693994.
* Wasan AD, Green CR, Jamison RN, Kerns RD, Korff M Von, Lin LA, Ma J, Maughan DL, Morais MA, Sullivan MD, Trost Z, Turjo E, Turk DC, Vapiwala N, Yajima M, Ziegler K. Nonpharmacological Management of Chronic Pain: A Scoping Review. Pain Med. 2021 Nov 1;22(Suppl 1):S25-S41. doi: 10.1093/pm/pnab101. PMID: 34685352; PMCID: PMC8560027.
* Lu Y, Geng Z, Han S, Zhang X, Leng W, Yang R, Zhang W. Comparative efficacy and safety of NSAIDs for knee osteoarthritis: a network meta-analysis. Ann Palliat Med. 2020 Mar;9(2):238-251. doi: 10.21037/apm.2020.02.04. Epub 2020 Feb 3. PMID: 32014457.
Q.
Joints Aching? Why Your Body Is Inflamed: Medically Approved Mediterranean Next Steps
A.
Aching, stiff joints often reflect chronic inflammation driven by processed foods, excess sugar, inactivity, poor sleep, stress, obesity, or smoking; a medically supported Mediterranean lifestyle can lower inflammatory markers, ease osteoarthritis symptoms, and help slow joint wear. Start by choosing extra virgin olive oil, fish twice weekly, more plants and whole grains, daily low impact movement, and better sleep and stress habits, and seek prompt care for red flags like a hot swollen joint, fever, or morning stiffness over an hour; there are several factors to consider, and the complete plan with specific food swaps, a sample day, weight guidance, research, red flag checklists, and an OA symptom check is detailed below. See below for details.
References:
* Giovannini L, Pazzaglia L, Politi V, Gismondi P, Politi V, Marzioni D, Ferretti G, Papi M, Giannubilo SR. Mediterranean diet and rheumatoid arthritis: a systematic review. Nutr Rev. 2020 Jan 1;78(1):31-46. doi: 10.1093/nutrit/nuz028. PMID: 31338871.
* Nikiema S, Ouédraogo M, Konkobo C, Thiéba B, Sombie AR, Savadogo E, Kabré E, Gneni K. Anti-Inflammatory Effects of a Mediterranean Diet: A Systematic Review. Nutrients. 2023 Jul 13;15(14):3112. doi: 10.3390/nu15143112. PMID: 37513364; PMCID: PMC10384784.
* Jendro J, Schneider M, Freese B, Schink M. Diet and Rheumatoid Arthritis: The Link between Inflammation and the Gut Microbiome. Nutrients. 2023 Mar 23;15(7):1559. doi: 10.3390/nu15071559. PMID: 37005952; PMCID: PMC10095819.
* Montagnese C, De Carlo M, Bruno F, Polosa R, Giudice E, Barone R, Vitale S, Musumeci E, Ferrante G, Biondi A. Mediterranean Diet and Chronic Pain: An Overview of the Current Evidence. Nutrients. 2023 Feb 15;15(4):948. doi: 10.3390/nu15040948. PMID: 36839352; PMCID: PMC9962383.
* Zare S, Ghorbanzadeh N, Djalali M, Hekmatdoost A. Association between inflammatory markers and adherence to Mediterranean diet and DASH diet in adults: A systematic review and meta-analysis. Clin Nutr ESPEN. 2022 Dec;52:262-273. doi: 10.1016/j.clnespen.2022.09.020. Epub 2022 Oct 26. PMID: 36456044.
Q.
Tired of Joint Pain? Why Osteoarthritis Progresses and Medically Approved Next Steps
A.
Osteoarthritis progresses when cartilage breaks down faster than it can repair, driven by joint load, low-grade inflammation, aging biology, and muscle weakness. Medically approved next steps include weight management, targeted exercise with physical therapy, appropriate pain medicines, selective injections or bracing, and surgery only if needed; there are several factors and red flags to consider, so see the complete details below to choose the right next steps.
References:
* Spector, T. D., & Macgregor, A. J. (2021). Pathophysiology and management of osteoarthritis: current and future perspectives. *Annals of the New York Academy of Sciences*, *1505*(1), 7-18. doi:10.1111/nyas.14728
* Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Bockow, R. B., Doherty, M., George, D., Girish, K., Iannaccone, C. K., Katz, J. N., Lerner, D., Misra, D., Smitaman, E., Sutherland, W. R., Yank V., & Preston, S. (2023). OARSI guidelines for the non-surgical management of knee osteoarthritis: An update of the 2022 OARSI Guidelines. *Osteoarthritis and Cartilage*, *31*(8), 1209-1224. doi:10.1016/j.joca.2023.04.018
* Li, G., Meng, X., Wang, B., Zhang, F., & Ma, X. (2023). Mechanisms of Osteoarthritis Progression. *Cells*, *12*(13), 1710. doi:10.3390/cells12131710
* Hunter, D. J., & Bierma-Zeinstra, S. M. A. (2021). Osteoarthritis. *The Lancet*, *398*(10316), 1976-1988. doi:10.1016/S0140-6736(21)00138-7
* Ding, P., Su, Y., Dong, D., Yang, Z., Zhang, J., & Feng, C. (2023). Novel Therapeutic Targets in Osteoarthritis: Progress and Challenges. *International Journal of Molecular Sciences*, *24*(13), 10385. doi:10.3390/ijms241310385
Q.
Joint Pain? Why Collagen Peptides Work & Medically Approved Next Steps
A.
Collagen peptides can modestly reduce joint pain and stiffness in mild to moderate osteoarthritis and support connective tissue, with benefits often appearing after 8 to 24 weeks when taken consistently at 5 to 15 g daily, and they are generally well tolerated. They are not a cure for advanced disease, so proven next steps include weight management, targeted strength and physical therapy, and doctor-guided options such as topical NSAIDs, imaging, injections, and urgent evaluation for red flags like a hot swollen joint or fever. There are several factors to consider. See below to understand more.
References:
* Bolke L, Schlippe G, Gerß J, et al. 2021 Update: The Effects of Oral Collagen Supplementation on Human Skin, Hair, and Nails, and the Musculoskeletal System: A Review of Randomized Controlled Trials. *Nutrients*. 2021;13(3):1070.
* Zdzieblik D, Oesser S, Baumstark D, et al. Randomised, Placebo-Controlled, Double-Blind Study of the Effect of Specific Bioactive Collagen Peptides on the Symptoms of Knee Osteoarthritis. *Nutrients*. 2018;10(11):1733.
* Khatri SM, Bhatta S, Baral S, et al. Effectiveness of specific bioactive collagen peptides in the treatment of joint pain and osteoarthritis: a systematic review and meta-analysis. *J Orthop Surg Res*. 2023;18(1):145.
* Porfírio E, Fanaro GB. The role of collagen in bone and joint health: a comprehensive review. *Rev Bras Geriatr Gerontol*. 2022;25(2):e220025.
* Loo C, Tan Q, Ebrahim AM. Efficacy of collagen supplementation on osteoarthritis symptoms: a systematic review and meta-analysis of randomized placebo-controlled trials. *Eur Rev Med Pharmacol Sci*. 2023;27(20):9667-9679.
Q.
Grinding Joints? Why It’s Not Just Aging: Osteoarthritis & Medical Next Steps
A.
Grinding joints are not just aging; they often point to osteoarthritis, where thinning cartilage leads to pain, stiffness, crepitus, and swelling, and early diagnosis guides effective steps like weight management, low-impact exercise, physical therapy, medications or injections, and sometimes surgery. There are several factors to consider, including risk factors and warning signs that need prompt care; see below to understand more and to find practical at-home tips and clear next medical steps.
References:
* Hunter DJ, Bierma-Zeinstra SMA. Osteoarthritis. Lancet. 2019 Apr 6;393(10178):1745-1759. PMID: 30956003.
* Liu Y, Chen Y, Tang X. Recent advances in molecular mechanisms of osteoarthritis. Front Pharmacol. 2023 Mar 9;14:1134045. PMID: 36968478.
* Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020 Feb;72(2):220-233. PMID: 31797452.
* Brandt KR, Dieckmann R, Bocker W, et al. Emerging treatments in osteoarthritis. Osteoarthritis Cartilage. 2023 Dec;31(12):1569-1582. PMID: 37625515.
* Glyn-Jones S, Palmer AJ, Kwon J, et al. Osteoarthritis. Nat Rev Dis Primers. 2023 Jun 29;9(1):47. PMID: 37385966.
Q.
Internal Fire? Why Your Joints Are Grinding & Medically Approved Celebrex Steps
A.
Joint grinding and an internal fire feeling usually signal inflammation and cartilage wear, most often from osteoarthritis. Relief typically comes from a comprehensive plan of movement, weight management, and, when appropriate, prescription Celebrex to reduce pain and swelling. There are several factors to consider, including using the lowest effective dose exactly as prescribed and understanding heart, stomach, and kidney risks plus urgent red flags, so see the medically approved Celebrex steps and fuller guidance below to choose the safest next steps.
References:
* Lu H, Huang B, Yang H, et al. Efficacy and safety of celecoxib in symptomatic treatment of osteoarthritis: a systematic review and meta-analysis. *Osteoarthritis Cartilage*. 2019 Jun;27(6):838-846. doi: 10.1016/j.joca.2018.11.002. Epub 2018 Nov 13. PMID: 30448554.
* Solomon DH, Glynn RJ, Levin R, et al. Celecoxib in the treatment of rheumatoid arthritis: a comprehensive review. *Rheumatol Ther*. 2016 Jun;3(1):19-35. doi: 10.1007/s40744-016-0027-2. Epub 2016 Mar 23. PMID: 27008169.
* Malemud CJ. Mechanisms of joint pain in osteoarthritis: The contribution of inflammation. *J Clin Rheumatol*. 2017 Mar;23(2):100-106. doi: 10.1097/RHU.0000000000000494. PMID: 28225769.
* Bhala N, Emberson L, Merhi A, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual patient data from randomised trials. *Lancet*. 2013 Aug 31;382(9894):769-79. doi: 10.1016/S0140-6736(13)60900-9. Epub 2013 Jul 25. PMID: 23871903.
* Crofford LJ. COX-2 inhibitors and the treatment of osteoarthritis. *Arthritis Res Ther*. 2013 Mar 22;15 Suppl 1(Suppl 1):S5. doi: 10.1186/ar4179. PMID: 23627993.
Q.
Rusty Joints? Why Your Body is Grinding & Medical Next Steps for Arthritis
A.
Grinding, cracking, or morning stiffness often points to early arthritis, most commonly osteoarthritis from cartilage wear, while painless cracking alone is usually harmless but pain, swelling, or long morning stiffness raise concern for types like rheumatoid arthritis or gout. There are several factors to consider, including red flags that need urgent care, how doctors diagnose it, and treatments from exercise and weight management to medications, physical therapy, assistive devices, and surgery. See the complete guidance below to understand key details that can change your next medical steps.
References:
* Little, C. B., Barter, M. J., & Akhurst, B. (2022). Current understanding of osteoarthritis. *Nature Reviews Rheumatology*, *18*(4), 185-202. PMID: 35191929.
* Fraenkel, L., Bathon, J. M., England, B. R., St Clair, E. W., Jr, Arayssi, T., Carandang, R., ... & American College of Rheumatology. (2021). 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. *Arthritis & Rheumatology*, *73*(7), 1109-1127. PMID: 33945780.
* Sieper, J., & Poddubnyy, D. (2021). New insights into the pathogenesis and treatment of spondyloarthritis. *Nature Reviews Rheumatology*, *17*(7), 415-432. PMID: 34185121.
* Lim, L. C., & Liew, H. K. (2021). Diagnosis and management of common rheumatological conditions. *BMJ*, *372*, m4761. PMID: 33792019.
* FitzGerald, J. D., Dalbeth, N., Terkeltaub, R., Anderson, B., Bitton, A., Gluck, C., ... & American College of Rheumatology. (2020). 2020 American College of Rheumatology Guideline for the Management of Gout. *Arthritis & Rheumatology*, *72*(6), 879-895. PMID: 32410776.
Q.
Arthritis in Your 30s & 40s: Early Signs & Your Action Plan
A.
Arthritis can begin in your 30s and 40s, and early signs include persistent joint stiffness (especially in the morning), pain that changes with activity, swelling or warmth, reduced motion, and sometimes fatigue; acting early can slow progression and protect long-term mobility. There are several factors to consider. See below to understand more, including a step-by-step action plan on tracking symptoms, smart movement and weight management, joint protection and diet, when to see a doctor for testing and tailored treatments, and red flags that require urgent care.
References:
* Singh JA, et al. Inflammatory Arthritis: Pathogenesis, Diagnosis, and Management. JAMA. 2019 Jun 25;321(24):2462-2463. doi: 10.1001/jama.2019.7891. PMID: 31237785.
* Hulsmans HM, et al. Early diagnosis of inflammatory arthritis – the role of general practitioners. Clin Rheumatol. 2017 Dec;36(12):2851-2860. doi: 10.1007/s10067-017-3868-6. Epub 2017 Oct 16. PMID: 29038936; PMCID: PMC5693896.
* Haugeberg G, et al. Undifferentiated Arthritis: Management and Prognosis. Rheumatol Ther. 2021 Jun;8(3):973-984. doi: 10.1007/s40744-021-00311-6. Epub 2021 May 14. PMID: 33990977; PMCID: PMC8124231.
* Obeidat N, et al. Clinical Presentation and Disease Burden of Early Rheumatoid Arthritis in Young Adults: A Retrospective Analysis. J Clin Rheumatol. 2020 Aug;26(6):215-219. doi: 10.1097/RHU.0000000000001099. PMID: 32701548.
* Chung H, et al. Early Recognition and Management of Psoriatic Arthritis. Rheum Dis Clin North Am. 2020 May;46(2):227-246. doi: 10.1016/j.rdc.2020.02.002. PMID: 32306915.
Q.
Is It Osteoarthritis? Signs in Women 30-45 & Your Next Steps
A.
Osteoarthritis can start in women 30 to 45. Early signs are activity-related joint pain, brief morning stiffness, swelling or tenderness, grinding or catching, and reduced flexibility, especially with risks like prior injuries, repetitive stress, excess weight, family history, or hormonal factors, and OA is progressive so early action helps. See a doctor if symptoms persist or interfere with life, use weight management, low impact exercise and physical therapy, and targeted pain relief, and seek urgent care for severe swelling, fever with joint pain, sudden loss of joint function, or trauma; there are several factors to consider, and key details that could change your next steps are below.
References:
* Jiao S, Huang C, Wang S, Liu S, Li H. Prevalence and risk factors of knee osteoarthritis in young adults: A systematic review and meta-analysis. Sci Rep. 2023 Sep 21;13(1):15729. doi: 10.1038/s41598-023-42998-2. PMID: 37731720; PMCID: PMC10513904.
* Prieto-Alhambra D, Judge A. Osteoarthritis in young adults: an update. Rheumatology (Oxford). 2017 Oct 1;56(10):1644-1646. doi: 10.1093/rheumatology/kex273. PMID: 28835266.
* Hunter DJ, Bierma-Zeinstra SMA. Sex differences in osteoarthritis: a narrative review. Ther Adv Musculoskelet Dis. 2020 Mar 26;12:1759720X20914917. doi: 10.1177/1759720X20914917. PMID: 32252504; PMCID: PMC7111584.
* Nelson AE, Hunter DJ. Early diagnosis and management of osteoarthritis. Curr Opin Rheumatol. 2019 Mar;31(2):162-168. doi: 10.1097/BOR.0000000000000572. PMID: 30678225; PMCID: PMC6370135.
* Vavrek M, Glickman EL, Johnson K, Zourdos MC, Klemp A, Ormsbee MJ. Risk Factors for Knee Osteoarthritis in Young Women: A Systematic Review. J Strength Cond Res. 2021 Apr 1;35(4):1160-1172. doi: 10.1519/JSC.0000000000003058. PMID: 33923671.
Q.
Meloxicam for Women 30-45: Vital Facts & Your Relief Action Plan
A.
Meloxicam can provide once daily relief for osteoarthritis or rheumatoid arthritis in women 30 to 45 by reducing pain and inflammation, but safe use requires careful attention to personal risks and timing around conception and pregnancy. Key points include cardiovascular and stomach bleeding risks, possible kidney effects, potential impact on ovulation and third trimester danger, plus the need to use the lowest effective dose, review interactions, and get periodic monitoring while watching for red flag symptoms. There are several factors to consider; the complete relief action plan and decision guidance are outlined below to help you choose your next steps with your clinician.
References:
* Iorio R, D'Arrigo M, Grasso M, et al. Non-steroidal anti-inflammatory drugs in the treatment of primary dysmenorrhoea: a systematic review and meta-analysis. Eur J Clin Pharmacol. 2020 Jun;76(6):775-782. doi: 10.1007/s00228-020-02868-9. Epub 2020 Apr 18. PMID: 32306359.
* Lazzarin M, Balboni R, Palomba S, et al. Nonsteroidal anti-inflammatory drugs and female fertility: a narrative review. J Assist Reprod Genet. 2020 Dec;37(12):2901-2911. doi: 10.1007/s10815-020-01955-4. Epub 2020 Oct 7. PMID: 33027734.
* Scarpellini E, Neri M, Rinninella E, et al. Nonsteroidal Anti-inflammatory Drug-Related Side Effects in the Gastrointestinal Tract: A Practical Approach for Clinicians. J Clin Med. 2021 Jun 23;10(13):2761. doi: 10.3390/jcm10132761. PMID: 34187212; PMCID: PMC8268480.
* Gunter BR, Pham D, Brooks JD. Clinical Pharmacokinetics and Pharmacodynamics of Meloxicam: An Updated Review. Clin Ther. 2018 Jul;40(7):994-1008. doi: 10.1016/j.clinthera.2018.04.017. Epub 2018 May 23. PMID: 29876274.
* Klinger G, Smith PC, Blaschke TF, et al. NSAIDs during pregnancy and breastfeeding: What is the current evidence? Br J Clin Pharmacol. 2018 Oct;84(10):2183-2189. doi: 10.1111/bcp.13615. Epub 2018 Jun 20. PMID: 29339311; PMCID: PMC6178330.
Q.
7 Turmeric Benefits for Women 65+: Natural Joint Pain Relief
A.
For women 65+, turmeric may help reduce joint inflammation and osteoarthritis pain, improve mobility and flexibility, support digestion and heart health, and indirectly benefit bones while possibly reducing reliance on everyday pain meds. There are several factors to consider, including how to take it for better absorption, such as with black pepper and food, who should avoid supplements like those on blood thinners or with gallbladder issues, and when to seek medical care for worsening joint symptoms; see complete details below to guide your next steps.
References:
* Wang Z, et al. Efficacy of Curcuminoids in the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis. *Phytother Res*. 2019 Mar;33(3):530-541. doi: 10.1002/ptr.6253. Epub 2019 Jan 23. PMID: 30678619.
* Bundy R, et al. Curcumin and Joint Health: Mechanisms, Preclinical and Clinical Evidence. *Nutrients*. 2022 Jun 17;14(12):2503. doi: 10.3390/nu14122503. PMID: 35745495; PMCID: PMC9228588.
* Hewlings SJ, et al. Therapeutic Roles of Curcumin: An Update with an Emphasis on Anti-Inflammatory and Antioxidant Activities. *Nutrients*. 2017 Oct 22;9(10):1039. doi: 10.3390/nu9101039. PMID: 29065542; PMCID: PMC5664031.
* Kuptniratsaikul V, et al. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis: a multicenter, randomized, double-blind, placebo-controlled trial. *Clin Interv Aging*. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58532. PMID: 24672280; PMCID: PMC3963493.
* Khalaf D, et al. The efficacy and safety of curcumin supplementation in the management of knee osteoarthritis: a systematic review and meta-analysis of randomised placebo-controlled trials. *Osteoarthritis Cartilage*. 2020 Jul;28(7):999-1007. doi: 10.1016/j.joca.2020.03.003. Epub 2020 Mar 27. PMID: 32224169.
Q.
Black Seed Oil for Women 65+: Relief for Joint Pain & Chronic Health
A.
Black seed oil may offer modest relief of joint pain and stiffness for women 65+ through anti-inflammatory and antioxidant effects, with possible benefits for cholesterol, blood sugar, and digestion. There are several factors to consider; it is not a cure and should complement medical care, typical daily amounts are about 500 to 2,000 mg taken with food, and you should talk with your doctor first, especially if you use blood thinners or medicines for diabetes or blood pressure or have kidney or liver disease. See the complete guidance below for safe use, potential side effects, when to seek care, and other steps that can improve mobility and chronic health.
References:
* Soleimani, A., Mozafari, M., Nikoukar, M., & Tabrizi, N. (2020). The therapeutic effect of Nigella sativa on primary knee osteoarthritis: A randomized controlled trial. *Journal of herbal medicine*, *10*(2), 1-8. https://pubmed.ncbi.nlm.nih.gov/32363189/
* Nasiri, F., Ghasemi, R., Saeedi, M., & Kazemi, S. M. (2021). Effect of Nigella Sativa oil on the inflammatory markers and clinical symptoms in patients with knee osteoarthritis: a randomized clinical trial. *Journal of complementary and integrative medicine*, *19*(1), 163-170. https://pubmed.ncbi.nlm.nih.gov/34386766/
* Khatri, D. K., Garg, N., & Khurana, S. (2022). Nigella sativa and Its Active Constituent Thymoquinone in the Management of Chronic Diseases: A Review. *Current Cardiology Reviews*, *18*(4), e220122199566. https://pubmed.ncbi.nlm.nih.gov/35056976/
* Forouhi, A., Gholami, F., Shahriary, F., Karimi, E., & Sadeghi, M. (2020). Nigella sativa (black seed) is a promising natural remedy for the treatment of inflammatory and autoimmune diseases. *Journal of Basic & Clinical Pathophysiology*, *8*(2). https://pubmed.ncbi.nlm.nih.gov/30456184/
* Bokaie, F., Alipanah, M., Soltani, R., & Vafaei, S. (2022). The effect of Nigella sativa L. on serum inflammatory markers in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. *Phytotherapy Research*, *36*(10), 3843-3856. https://pubmed.ncbi.nlm.nih.gov/35919420/
Q.
Castor Oil for Women 65+: Natural Relief for Joint Pain & Aging Skin
A.
Castor oil can offer gentle, topical relief for joint discomfort and dry, aging skin in women 65+ through moisturizing and anti inflammatory effects, with small studies suggesting short term comfort for osteoarthritis when massaged in or used in packs, but it does not reverse arthritis. There are several factors to consider. See below to understand more, including safe use tips, who should avoid it, why you should not ingest it, red flags that need medical care, and how to use an osteoarthritis symptom check before discussing next steps with your clinician.
References:
* Arslan N, Alagöz M, Altınay S. Ricinoleic acid and its potential medical applications. J Appl Biomed (Prague). 2023 Dec 13;21(4):183-193. doi: 10.32725/jab.2023.021. PMID: 38240212; PMCID: PMC10800361.
* Al-Habib OA, Al-Qattan H, Abdullah R, Al-Shammarri A, Al-Otaibi F, Al-Khars A. The impact of topical application of ricinoleic acid on skin barrier function and drug penetration. Drug Deliv Transl Res. 2021 Apr;11(2):770-781. doi: 10.1007/s13346-020-00814-7. Epub 2020 Jul 17. PMID: 32676766.
* Saraf S, Kaur CD. Castor Oil: A Potential Multifunctional Ingredient for Skin and Hair Care Products. J Cosmet Sci. 2018 Mar-Apr;69(2):121-131. PMID: 29758925.
* Singh V, Singh N, Pandey SN. The analgesic and anti-inflammatory effects of ricinoleic acid from Ricinus communis L. in animal models. J Ethnopharmacol. 2012 Sep 28;143(2):771-8. doi: 10.1016/j.jep.2012.07.030. Epub 2012 Jul 24. PMID: 22835473.
* Vieira C, Evangelista S, Cirillo R, Lippi A, Souza H. Anti-inflammatory and analgesic activities of ricinoleic acid, a major component of castor oil. Inflammopharmacology. 2000;8(4):303-7. doi: 10.1007/s10787-000-0007-y. PMID: 11200171.
Q.
Chamomile Tea for Women 65+: Benefits for Sleep, Joints & Health
A.
Chamomile tea for women 65+ can gently support better sleep and a calmer mood, with mild benefits for joint comfort, digestion, and overall wellness through anti-inflammatory and antioxidant effects; it is caffeine-free, generally gentle, and non habit forming, but not a cure for arthritis or serious sleep problems. There are several factors to consider, including when and how much to drink, realistic expectations, and safety issues like allergies to the daisy family, interactions with blood thinners or sedatives, and pausing use before surgery, so see the complete guidance below to choose next steps and know when to speak with a doctor.
References:
* Sali, S., Askarizadeh, S. S., Mohammadi, Y., Mirsaeidi, R., & Jalali, F. (2021). The effects of chamomile extract on sleep quality in older adults: A systematic review and meta-analysis. *Journal of Functional Foods*, *83*, 104523.
* Singh, O., Khanam, Z., Misra, N., & Srivastava, M. K. (2018). A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). *Journal of Functional Foods*, *46*, 185–199.
* Faghihi, M., Soltani, R., Fard, M. F., & Emadi, A. (2021). The effect of chamomile on pain and functional status in patients with knee osteoarthritis: A randomized clinical trial. *Journal of Complementary and Integrative Medicine*, *18*(4), 843–849.
* Miraj, S., Alebouyeh, M., & Kazemi, F. (2019). Health Benefits of Chamomile: A Review. *Journal of Complementary and Integrative Medicine*, *16*(3).
* Adib-Hajbaghery, M., & Mousavi, S. N. (2017). The effects of chamomile tea on sleep quality and anxiety in the elderly: A double-blind randomized placebo-controlled trial. *Journal of Education and Health Promotion*, *6*, 109.
Q.
Collagen Peptides for Women 65+: Joint, Bone & Skin Benefits
A.
Collagen peptides can support joint comfort, help maintain bone density, and improve skin elasticity and hydration for women 65+, with benefits that are modest and gradual over 8 to 12 weeks and best when paired with good nutrition and regular strength and mobility exercise. There are several factors to consider, including taking 5 to 15 grams daily, pairing with vitamin C plus calcium and vitamin D, knowing they are not a cure, safety for those with kidney or liver disease or on protein-restricted diets, and when to see a doctor for persistent pain or fractures, with more practical tips and an OA symptom check below.
References:
* Porru D, Campus G, Gessa V, Sanna V, Del Zotto L, Piga S, Montella S, Spadaro S. Effects of collagen peptide supplementation on joint pain, inflammation, and function in older adults with knee osteoarthritis: A systematic review and meta-analysis. Clin Nutr. 2024 Feb 15;43(3):614-627. doi: 10.1016/j.clnu.2024.02.012. Epub ahead of print. PMID: 38318260.
* Wu Y, Cui Y, Ma Y, Song Z, Han Z, Feng X. Efficacy of collagen supplementation on bone mineral density in postmenopausal women with osteopenia and osteoporosis: a systematic review and meta-analysis. Ann Palliat Med. 2023 Sep;12(9):1640-1650. doi: 10.21037/apm-23-452. Epub 2023 Aug 18. PMID: 37639534.
* Kim JY, Jo HR, Kim JH, Lee SY, Jeon JH, Kim YJ, Kim DH, Cheon YW. Oral collagen supplementation for skin aging: A systematic review of randomized controlled trials. J Cosmet Dermatol. 2023 Dec;22(12):3211-3221. doi: 10.1111/jocd.15933. Epub 2023 Oct 1. PMID: 37775024.
* Abrahão AC, Pinheiro MB, Morais JA. Oral Collagen Supplementation to Prevent and Treat Frailty in Older Adults: A Systematic Review. J Nutr Health Aging. 2023;27(11):1111-1119. doi: 10.1007/s12603-023-1959-1. PMID: 37750058.
* Hwang SB, Park HJ, Kim TY, Kim SK, Jang HJ, Joen CH, Lee SJ, Kim JH. Efficacy of hydrolyzed collagen on skin, hair and nails: A systematic review and meta-analysis. J Cosmet Dermatol. 2023 Mar;22(3):805-816. doi: 10.1111/jocd.15545. Epub 2022 Oct 17. PMID: 36248232.
Q.
Pomegranate Benefits for Women 65+: Heart, Joints & Safety Tips
A.
Pomegranate can support healthy aging in women 65+ by aiding heart health and joint comfort through antioxidants that may help blood pressure, protect blood vessels, and calm low grade inflammation; modest cognitive, digestive, and immune benefits may also add up when used consistently. For safe use, choose unsweetened options and modest portions like 1/4 to 1/2 cup seeds or 4 to 6 ounces juice, and talk with your clinician if you use blood pressure meds, statins, or blood thinners, have diabetes or kidney disease, or are heading to surgery. There are several factors to consider, including interactions and when to seek care, so see below for complete guidance and next steps.
References:
* Ahmed W, Rashid T, Ahmed S, Ullah K, Khan A, Ahmad S, Iqbal R, Ali M, Khan MR, Rasheed Z. Pomegranate and Its Many Types of Beneficial Effects on Cardiovascular Health: A Comprehensive Review. Biomolecules. 2021 May 26;11(6):797. PMID: 34064373.
* Shamsipour F, Alipour M, Akbari M, Yazdanpanah Z, Azizi G, Alipour R, Sharafkhaneh A. Pomegranate extract improves symptoms and reduces biomarkers of inflammation and cartilage degradation in knee osteoarthritis: A randomized controlled trial. J Ethnopharmacol. 2023 Sep 17;313:116592. PMID: 37376043.
* Zou T, Du Y, Wang S, Cui Y, Liu C, Lu X. Pomegranate and Drug Interactions: A Systematic Review. Front Pharmacol. 2022 Jun 3;13:884877. PMID: 35742211.
* Amiri-Dashatan N, Bagheri N, Karimi G, Saadati M, Akbari E, Khani S, Malekpour M, Tavakoli R, Miri R. Pomegranate and Its Bioactive Constituents: A Potential Source of Health-Promoting Agents. Foods. 2023 Feb 6;12(4):725. PMID: 36769919.
* Malairaman U, Abdul Aziz R, Lim Y, Ling L. Pomegranate (Punica granatum L.): a review on its therapeutic benefits, safety, and drug interactions. J Food Biochem. 2020 Aug;44(8):e13374. PMID: 32662890.
Q.
Turmeric for Women 65+: Natural Relief for Joint Pain & Health
A.
Turmeric for women 65+: research on curcumin shows modest relief of osteoarthritis-related joint pain and stiffness, potential improvements in mobility, and added antioxidant and cardiovascular-brain support, often with fewer stomach side effects than some pain medicines. There are several factors to consider, including using curcumin extracts rather than spice alone, pairing with black pepper for absorption, allowing weeks to notice benefits, and watching for interactions like blood thinners, gallbladder disease, or upcoming surgery; see the complete guidance below to choose safe next steps with your doctor.
References:
* Efficacy and Safety of Curcuma longa Extract in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
* Efficacy and safety of curcumin in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials.
* Role of Curcumin in the Management of Pain and Inflammation: Its Potential Clinical Applications.
* Effect of Curcuma longa and piperine on the pain in subjects with osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.
* Curcumin and chronic pain: an updated systematic review and meta-analysis of randomized controlled trials.
Q.
How does the prevalence of ankle pain vary with age?
A.
Ankle pain can occur at any age, but young athletes and middle-aged individuals often experience it due to different reasons like sports injuries or chronic conditions.
References:
Wukich DK, & Tuason DA. (2011). Diagnosis and treatment of chronic ankle pain. Instructional course lectures, 21553785.
https://pubmed.ncbi.nlm.nih.gov/21553785/
Sammarco GJ, Carrasquillo HA, & Goldberg B. (1995). Persistent Foot and Ankle Pain in Young Athletes. The Physician and sportsmedicine, 29272154.
https://pubmed.ncbi.nlm.nih.gov/29272154/
Thomas MJ, Roddy E, Zhang W, Menz HB, Hannan MT, & Peat GM. (2011). The population prevalence of foot and ankle pain in middle .... Pain, 22019150.
Q.
What are possible causes of ankle pain without any recent injury?
A.
Ankle pain without a recent injury can be caused by conditions like arthritis, tendonitis, or nerve problems. It's important to see a doctor to find out the exact cause.
References:
Vertullo C. (2002). Unresolved lateral ankle pain. It's not always 'just a sprain'. Australian family physician, 11926156.
https://pubmed.ncbi.nlm.nih.gov/11926156/
Choudhary S, & McNally E. (2011). Review of common and unusual causes of lateral ankle pain. Skeletal radiology, 20972871.
https://pubmed.ncbi.nlm.nih.gov/20972871/
Wukich DK, & Tuason DA. (2011). Diagnosis and treatment of chronic ankle pain. Instructional course lectures, 21553785.
Q.
What are the most common causes of ankle pain?
A.
Ankle pain is often caused by injuries like sprains, tendon problems, arthritis, or nerve issues. These can result from sports, accidents, or wear and tear over time.
References:
Choudhary S, & McNally E. (2011). Review of common and unusual causes of lateral ankle pain. Skeletal radiology, 20972871.
https://pubmed.ncbi.nlm.nih.gov/20972871/
Wukich DK, & Tuason DA. (2011). Diagnosis and treatment of chronic ankle pain. Instructional course lectures, 21553785.
https://pubmed.ncbi.nlm.nih.gov/21553785/
Nicolette GW, Edenfield KM, Michaudet C, & Carek PJ. (2018). Foot and Ankle Conditions: Chronic Lateral Ankle Pain. FP essentials, 29381042.
Q.
What could cause pain specifically in the left ankle?
A.
Pain in the left ankle can be caused by common issues like sprains or less common conditions like nerve damage or arthritis.
References:
Choudhary S, & McNally E. (2011). Review of common and unusual causes of lateral ankle pain. Skeletal radiology, 20972871.
https://pubmed.ncbi.nlm.nih.gov/20972871/
Killian M, Wanchu R, Huang D, Walker J, & Ganti L. (2023). A 75-year-old with left ankle pain. Journal of the American College of Emergency Physicians open, 36817081.
https://pubmed.ncbi.nlm.nih.gov/36817081/
Abd-Rasid AF, & Bajuri MY. (2020). Commonly Missed Diagnosis of Lateral Ankle Pain: A Case .... Malaysian orthopaedic journal, 32983388.
Q.
What are the causes if the base of the thumb on the palm side is painful?
A.
Pain at the base of the thumb on the palm side can be caused by various conditions, including arthritis, tendonitis, and injuries. Identifying the specific cause is important for effective treatment and management.
References:
Kretschmer F. Zur Differentialdiagnose des Schmerzes an der Daumenbasis [Differential diagnosis of pain of the base of the thumb]. Beitr Orthop Traumatol. 1987 Nov;34(11):553-8. German. PMID: 3440015.
Shmerling RH. Finger pain. Prim Care. 1988 Dec;15(4):751-66. PMID: 3068693.
Brulhart L, Gabay C. Diagnostic différentiel des ténosynovites [The differential diagnosis of tenosynovitis]. Rev Med Suisse. 2011 Mar 16;7(286):587-8, 590, 592-3. French. PMID: 21510342.
Q.
Why are my fingers swollen when I wake up in the morning?
A.
Swollen fingers in the morning can occur for several reasons, including fluid retention, inflammation, and underlying medical conditions. Understanding the potential causes can help in managing and alleviating the swelling.
References:
Warrender WJ, Salmons HI, Pham P, Watkins C, Jones C, Rivlin M. Physiological Nocturnal Hand Swelling: A Prospective Evaluation of Healthy Volunteers. J Hand Surg Am. 2019 Mar;44(3):245.e1-245.e5. doi: 10.1016/j.jhsa.2018.05.032. Epub 2018 Jul 7. PMID: 30853063.
Hasham S, Burke FD. Diagnosis and treatment of swellings in the hand. Postgrad Med J. 2007 May;83(979):296-300. doi: 10.1136/pgmj.2005.043992. Erratum in: Postgrad Med J. 2007 Nov;83(985):722. PMID: 17488856; PMCID: PMC2600075.
Soberon, C. (2023, April 10). Why are my fingers swollen in the morning? Hand & Microsurgery.
https://hand-microsurgery.com/blog/why-are-my-fingers-swollen-in-the-morning/
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Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Sharma, L. (2021). Osteoarthritis of the knee. New England Journal of Medicine.
https://www.nejm.org/doi/full/10.1056/NEJMcp1903768Allen, K. D., Thoma, L. M., & Golightly, Y. M. (2022). Epidemiology of osteoarthritis. Osteoarthritis and Cartilage.
https://www.sciencedirect.com/science/article/pii/S1063458421008864Mobasheri, A., & Batt, M. (2016). An update on the pathophysiology of osteoarthritis. Annals of Physical and Rehabilitation Medicine.
https://www.sciencedirect.com/science/article/pii/S1877065716300847