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Published on: 2/24/2026
Persistent bleeding can signal hemophilia, which occurs when clotting factors are missing or blocked, most often from inherited factor VIII or IX deficiency and sometimes from an immune problem that develops later in life.
There are several factors to consider; see below for key symptoms, risk clues, urgent red flags, and medically approved treatments including factor replacement, newer non factor medicines, and immune therapy for acquired cases, any of which can change your next steps. If bleeding does not stop after 10 to 15 minutes of firm pressure or follows a head injury, seek urgent care now.
If bleeding won't stop after a minor cut, dental work, or injury, it can be alarming. While many causes of prolonged bleeding are mild, one important condition doctors look for is hemophilia — a rare bleeding disorder that affects the body's ability to form blood clots properly.
Understanding why hemophilia happens and knowing the right next steps can help you respond quickly and safely.
Hemophilia is a medical condition where the blood does not clot the way it should. Normally, when you get hurt, your body uses special proteins called clotting factors to stop bleeding. In people with hemophilia, one of these clotting factors is missing or doesn't work correctly.
There are two main inherited types:
Both types lead to similar symptoms, but Hemophilia A is more common.
There is also a rare condition called Acquired Hemophilia, which develops later in life and is not inherited.
Most cases of hemophilia are inherited. The condition is linked to the X chromosome. Because males have only one X chromosome, they are more likely to have hemophilia if they inherit the affected gene. Females can be carriers and sometimes have mild symptoms.
You may be at higher risk if:
Acquired Hemophilia is different. It happens when the immune system mistakenly attacks clotting factor VIII. This can occur:
Unlike inherited hemophilia, Acquired Hemophilia often affects older adults and people with no personal or family history of bleeding disorders.
If you're experiencing unexplained or prolonged bleeding and have no family history of bleeding disorders, you can use a free Acquired Hemophilia symptom checker to help determine whether your symptoms may be related to this rare condition.
Symptoms can range from mild to severe depending on how much clotting factor is present in the blood.
Bleeding into joints is especially concerning because repeated episodes can cause long-term joint damage if untreated.
Seek urgent medical care if you notice:
Internal bleeding is not always visible, so unexplained pain, swelling, or weakness should never be ignored.
If bleeding is severe or life-threatening, call emergency services immediately.
If hemophilia is suspected, a doctor will order blood tests that measure:
These tests clearly show whether factor VIII or IX levels are low.
In inherited hemophilia, testing is often done in childhood, especially if there is family history. Acquired Hemophilia is usually diagnosed later in life, often after unexpected bleeding.
Modern treatment has greatly improved outcomes. With proper care, many people with hemophilia live full, active lives.
This is the main treatment for inherited hemophilia. It involves:
Replacement therapy can be given at home once patients are trained.
Newer medications help the body clot more effectively without replacing factor directly. These are often used in Hemophilia A.
Treatment usually involves:
Because Acquired Hemophilia can be serious, early treatment is critical.
Living with hemophilia requires some adjustments, but it does not mean living in fear.
Helpful steps include:
Many people with hemophilia work, exercise, travel, and raise families successfully with proper medical care.
Inherited hemophilia cannot be prevented, but genetic counseling can help families understand their risk.
Acquired Hemophilia cannot always be predicted, but early recognition of symptoms improves outcomes significantly.
Without treatment, hemophilia can lead to:
However, with early diagnosis and modern therapy, complications are far less common than in the past.
Today, life expectancy for many people with hemophilia approaches that of the general population, especially when treatment begins early.
If you or a loved one experiences unusual or prolonged bleeding:
If symptoms are new, unexplained, or occurring in adulthood without family history, using a free online tool to check your symptoms for Acquired Hemophilia can help you understand whether you should seek urgent medical evaluation.
Hemophilia is a serious but manageable bleeding disorder. It occurs when the body lacks important clotting factors, either due to inherited genetics or an immune system problem in Acquired Hemophilia.
Key takeaways:
If you suspect hemophilia — inherited or acquired — speak to a doctor promptly, especially if bleeding is heavy, sudden, or life-threatening. Quick medical attention can prevent complications and protect your long-term health.
Bleeding that won't stop is your body's way of signaling that something needs attention. Listening to that signal — calmly and promptly — is the smartest next step.
(References)
* Arai M. Hemophilia: a review of current knowledge and management. J Blood Med. 2023 Apr 5;14:263-275. doi: 10.2147/JBM.S397063. PMID: 37021577; PMCID: PMC10087790.
* Ma A, Moores M, Ragni MV. Current and future treatment options for patients with hemophilia. Blood Adv. 2021 Apr 22;5(8):2268-2281. doi: 10.1182/bloodadvances.2020002047. PMID: 33945890; PMCID: PMC8086082.
* Lillo E, Ruz-Barría S, Contreras V, Castro V, Varas-Godoy M, Valdés-Gallegos V. Hemophilia: Current Genetic Diagnosis and New Therapeutic Targets. Cells. 2022 Aug 4;11(15):2400. doi: 10.3390/cells11152400. PMID: 35955685; PMCID: PMC9367469.
* Srivastava A, Santagostino E, Dougall A, Kitchen S, Sutherland M, Pipe SW, Carcao M, Mahlangu J, Ragni MV, Windyga J, Llinas A, Goddard NJ, Mohan R, Poonnoose PM, Chalmers E, Salazar E, Horowitz MS, Chuansumrit A, Kandula V, Batt R, Krishnan S, Soucie JM, Bussell J, Hoots WK; WFH Guidelines for the Management of Hemophilia Panel. WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia. 2020 Aug;26 Suppl 6:1-158. doi: 10.1111/hae.14046. PMID: 36319139.
* Ronsoni M, Cavallaro S, Boffi M, Mancuso ME, Peyvandi F. Emerging Therapies in Hemophilia: Advances and Challenges. J Clin Med. 2023 Aug 24;12(17):5490. doi: 10.3390/jcm12175490. PMID: 37624794; PMCID: PMC10488669.
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