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Bruise easily
Bleeding/bruising in the joints
Rashes
Purplish rash
Bleeding nose
Redness of the skin
Black stools
Blood in vomit
Blood in urine
Joint pain or stiffness
Bright red vomit
Severe headaches
Not seeing your symptoms? No worries!
Acquired hemophilia is a rare autoimmune disorder causing bleeding tendencies due to the development of antibodies against clotting factors.
Your doctor may ask these questions to check for this disease:
Treatment focuses on managing bleeding episodes and addressing the underlying cause. Treatment options may include immune therapy to suppress the abnormal antibodies, desmopressin for mild cases, and factor replacement therapies.
Reviewed By:
Kaito Nakamura, MD (Rheumatology)
Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Content updated on Jan 23, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1NORD
https://rarediseases.org/rare-diseases/acquired-hemophilia/Kulkarni R, Soucie JM. Pediatric hemophilia: a review. Semin Thromb Hemost. 2011 Oct;37(7):737-44. doi: 10.1055/s-0031-1297164. Epub 2011 Dec 20. PMID: 22187396.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1297164Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):1-8. doi: 10.1182/hematology.2019000007. PMID: 31808868; PMCID: PMC6913446.
https://ashpublications.org/hematology/article/2019/1/1/422595/Gene-therapy-for-hemophiliaMehta P, Reddivari AKR. Hemophilia. [Updated 2023 Jun 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK551607/Pishko AM, Doshi BS. Acquired Hemophilia A: Current Guidance and Experience from Clinical Practice. J Blood Med. 2022 May 11;13:255-265. doi: 10.2147/JBM.S284804. PMID: 35592586; PMCID: PMC9112043.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9112043/