Age 65+: what causes a burning skin sensation with no rash?

Burning Sensation on Skin but Nothing There: Causes, Diagnosis & Next Steps for Ages 65+

A persistent “burning sensation on skin but nothing there” can be unsettling, especially for those over age 65. You’re not alone—many older adults experience this odd, painful feeling without any visible rash or irritation. Below we explain common causes, how doctors diagnose the issue, treatment options, and when to get medical help.

What Is a Burning Skin Sensation with No Rash?

• Often described as stinging, tingling or “pins and needles”
• Classified under neuropathic (nerve) pain or dysesthesia (abnormal sensation)
• May occur in patches or spread over arms, legs, torso or face
• No visible skin changes—no redness, bumps or rash

Common Causes in Age 65+

1. Diabetic Peripheral Neuropathy

   • Long-term high blood sugar injures peripheral nerves
   • Symptoms: burning, tingling, numbness starting in feet and hands
   • Up to 50% of seniors with diabetes develop neuropathy

2. Postherpetic Neuralgia

   • Follows a shingles (herpes zoster) outbreak
   • Pain persists ≥3 months after rash heals
   • More common in people > 60

3. Small Fiber Neuropathy

   • Damage to small nerve fibers that carry pain/temperature signals
   • May occur with diabetes, autoimmune disease or idiopathically
   • Diagnosed via skin biopsy or specialized nerve testing

4. Vitamin Deficiencies

   • B12, B6 or niacin deficiencies can cause neuropathic pain
   • Older adults often absorb vitamins less efficiently

5. Medication Side Effects

   • Statins, chemotherapy agents, some blood pressure drugs
   • Check with your pharmacist or doctor for side-effect profiles

6. Metabolic or Organ-Related Causes

   • Kidney disease (uremic neuropathy)
   • Liver dysfunction—buildup of toxins may irritate nerves
   • While elastography and noninvasive indices (Wai CT & Friedrich-Rust M) are used to stage liver fibrosis, similar noninvasive nerve tests exist in neurology (Lauria G & Hsieh ST)

7. Fibromyalgia

   • Widespread musculoskeletal pain, fatigue, sleep issues
   • Burning sensations may be part of the dysesthesia spectrum

8. Erythromelalgia

   • Rare, causes burning pain, redness, heat in hands/feet
   • Triggered by warmth or exercise

9. Compression or Spinal Stenosis

   • Pinched nerves in neck/back can send pain signals down arms or legs

10. Other Neurological Disorders

• Multiple sclerosis, stroke-related neuropathy, amyloidosis
• Often accompanied by other signs (weakness, vision changes)

11. Psychogenic**

• Rarely, anxiety or stress can heighten nerve sensitivity
• Usually a diagnosis of exclusion

When to Seek Medical Help

Talk to a doctor promptly if you experience:

• Sudden onset of severe burning pain
• Weakness, balance problems or difficulty speaking
• New bladder or bowel control issues
• Fever, unexplained weight loss, night sweats
• Signs of infection (redness, swelling, warmth)

How Doctors Diagnose the Cause

1. Medical History & Physical Exam
   • Duration, location, triggers, medications, medical conditions
2. Blood Tests
   • Blood sugar (HbA1c), kidney/liver function, B12 levels, thyroid
3. Neurological Testing
   • Nerve conduction studies, electromyography (EMG)
   • Skin biopsy for small fiber density (per Lauria G & Hsieh ST, 2010)
4. Imaging (if indicated)
   • MRI/CT of spine or brain to rule out compression, stroke
5. Referral to Specialists
   • Neurologist for complex neuropathies
   • Pain clinic or rheumatologist for fibromyalgia

Treatment Options

Treatment aims to reduce pain, improve function and address underlying causes.

• Topical Therapies

• Lidocaine 5% patches or gel
• Capsaicin cream (initial burning sensation may worsen briefly)

• Oral Medications

• Anti-seizure drugs: gabapentin, pregabalin
• SNRIs or TCAs: duloxetine, amitriptyline
• Pain relievers: tramadol, low-dose opioids (careful in seniors)

• Supplements & Nutrition

• Correct vitamin B12, B6, niacin deficiencies
• Omega-3 fatty acids may support nerve health

• Physical & Occupational Therapy

• Gentle stretching, balance exercises, TENS (nerve stimulation)
• Adaptive devices to protect numb areas

• Lifestyle & Self-Care

• Keep blood sugar in target range if diabetic
• Avoid extreme temperatures on sensitive skin
• Stress management: meditation, gentle yoga, breathing exercises

• Interventional Procedures (for severe cases)

• Nerve blocks, epidural steroid injections
• Spinal cord stimulation implants

Self-Care Tips to Ease Discomfort

• Wear soft, loose clothing to avoid friction
• Keep skin cool with cool compresses (avoid ice directly on skin)
• Moisturize dry skin—cracks can worsen sensations
• Balance activity with rest; don’t overexert painful areas
• Use proper footwear and cushioning for neuropathic feet

Next Steps & Resources

If you’re not sure what’s causing your burning skin sensation, consider doing a free, online symptom check for to gather more information before your appointment.

Always speak to a doctor about anything that could be serious or life threatening—don’t wait if symptoms worsen or new signs appear. Early diagnosis and treatment can significantly improve quality of life and prevent complications.

Stay proactive: track your symptoms, note any patterns or triggers, and share this information with your healthcare provider. Together you can find the underlying cause and the right treatment plan to help you live more comfortably.