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Published on: 1/14/2026
Doctors take persistent diarrhea seriously when key red flags are present: blood or pus, high fever, severe abdominal pain, signs of dehydration, unintentional weight loss, symptoms lasting more than 48 hours, recent antibiotics or travel, older age, or immunocompromise; see below for the full list and what to do next. These signs may point to infections like C. difficile, inflammatory bowel disease, malabsorption, or dangerous complications such as severe dehydration or acute kidney injury, so seek urgent care if any occur. There are several factors to consider, and the detailed guidance below explains self-care, when to see a doctor, and the tests doctors use.
It’s normal to have an occasional bout of loose or frequent stools. But when diarrhea becomes relentless, it can signal something more serious. Diarrhea is defined as passing three or more loose or liquid stools per day, or more than 200 grams of stool over 24 hours. Acute diarrhea lasts less than two weeks, while chronic diarrhea persists beyond four weeks. Most acute cases resolve on their own or with simple treatment, but certain warning signs—“red flags”—mean you should seek medical care promptly.
Frequent or uncontrollable pooping can stem from many conditions:
• Infections
– Viruses (norovirus, rotavirus)
– Bacteria (Salmonella, E. coli, Shigella, C. difficile)
– Parasites (Giardia)
• Medications
– Antibiotics (disrupt gut bacteria, risk C. difficile)
– Laxatives
– Magnesium-containing antacids
• Inflammatory Bowel Disease (IBD)
– Crohn’s disease
– Ulcerative colitis
• Irritable Bowel Syndrome (IBS) with diarrhea
• Malabsorption syndromes
– Celiac disease
– Pancreatic insufficiency
• Hormonal and metabolic causes
– Hyperthyroidism
– Adrenal disorders
• Post-surgical changes or anatomical issues (short bowel syndrome)
• Liver disease and cirrhosis
– Patients with decompensated cirrhosis may develop diarrhea from portal hypertension, bacterial overgrowth, or malnutrition (EASL Clinical Practice Guidelines, 2014).
Most diarrhea is mild and self-limited. However, contact a doctor right away if you—or someone you care for—have any of these warning signs:
• Blood or pus in stools
• High fever (above 38.5 °C or 101.3 °F)
• Severe, persistent abdominal pain
• Signs of dehydration:
– Very dry mouth or skin
– Reduced urine output or dark urine
– Dizziness or lightheadedness
• Unintentional weight loss (more than 5% of body weight)
• Diarrhea lasting more than 48 hours without improvement
• Recent antibiotic use (risk of C. difficile infection)
• Recent travel to developing countries
• Immunocompromised state (HIV, chemotherapy, organ transplant)
• Age over 70 years
• History of inflammatory bowel disease or colorectal cancer
• Evidence of systemic illness: rapid heart rate, low blood pressure
According to Mayo Clinic research (Foxx-Orenstein & McFarland, 2010), a stepwise approach helps identify the cause:
Detailed Medical History
Physical Examination
Laboratory Tests
Noninvasive Indices and Imaging
Endoscopy
Patients with cirrhosis, especially those with decompensated disease, often have altered gut motility and bacterial overgrowth. The European Association for the Study of the Liver (2014) highlights:
• Risk of spontaneous bacterial peritonitis
• Malabsorption of fats and fat-soluble vitamins
• Electrolyte imbalances that worsen ascites and encephalopathy
In these patients, new or worsening diarrhea may indicate disease progression and warrants prompt medical evaluation.
Recurring, severe diarrhea can lead to life-threatening complications:
• Severe dehydration and electrolyte disturbances
• Acute kidney injury
• Toxic megacolon in ulcerative colitis
• Hemolytic uremic syndrome (HUS) after certain E. coli infections
• Sepsis from C. difficile or other invasive infections
For mild, acute diarrhea without red-flag signs:
• Hydration
– Oral rehydration solutions (ORS) with balanced salt and glucose
– Clear broths, diluted fruit juices
• Dietary adjustments
– BRAT diet (bananas, rice, applesauce, toast)
– Avoid high-fat, spicy, or high-fiber foods until stools normalize
– Limit caffeine and alcohol
• Over-the-counter options
– Loperamide for short-term relief (avoid if fever or bloody stools)
– Probiotics may help restore healthy gut flora
• Rest and gradual return to normal activities
If you’re unsure about the severity of your symptoms, you might consider doing a free, online symptom check for to guide your next steps.
Even if you don’t have all the red-flag symptoms, schedule medical care if:
• Diarrhea persists longer than two days in adults
• You cannot keep down fluids for more than 24 hours
• You notice significant weight loss or ongoing fatigue
• There’s any blood in your stool or extreme abdominal pain
Frequent or uncontrollable pooping can range from a brief nuisance to a sign of serious disease. Recognizing the red flags and seeking timely care can prevent complications. Always keep hydration and nutrition in mind, and use self-care for mild cases. If you have any concerning symptoms, or if diarrhea persists despite home treatment, speak to your doctor without delay. For anything that could be life-threatening or seriously impact your health, professional evaluation is essential.
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