Our Services
Medical Information
Helpful Resources
Published on: 2/23/2026
CTE is a progressive brain disease from repeated head impacts, but it cannot be confirmed in life and its symptoms overlap with far more common, treatable problems like depression or anxiety, sleep disorders, thyroid or B12 issues, and post concussion effects. There are several factors to consider; see below to understand what truly raises concern and what often explains brain fog, mood shifts, and memory problems. Medically approved next steps include a primary care evaluation with cognitive testing, mood and sleep screening, targeted labs, and if needed imaging and neurology or neuropsychology referral, plus brain healthy habits and urgent care for red flags such as suicidal thoughts or sudden neurological changes, with full details and a step by step plan outlined below.
If you've been dealing with memory problems, mood changes, brain fog, or personality shifts—and you've had repeated head injuries—you may be wondering: Is it CTE?
It's a serious question. Chronic Traumatic Encephalopathy (CTE) has received widespread attention in athletes, veterans, and others exposed to repeated head trauma. But it's also widely misunderstood.
Let's break down what CTE is, why your brain may be struggling, and what medically approved next steps actually make sense.
CTE (Chronic Traumatic Encephalopathy) is a progressive brain disease linked to repeated head impacts. It has been most commonly studied in:
CTE is associated with abnormal buildup of a protein called tau in the brain. Over time, this buildup can affect thinking, mood, and behavior.
Currently, CTE can only be definitively diagnosed after death through brain tissue examination. There is no single test that can confirm CTE in a living person.
That's critical to understand before jumping to conclusions.
Research suggests CTE may be linked to:
However—and this is extremely important—these symptoms are not unique to CTE.
They overlap with many other conditions.
If you're experiencing cognitive or emotional changes, several much more common (and often treatable) causes may be responsible:
MCI involves noticeable memory or thinking problems that are greater than normal aging but not severe enough to be dementia.
If you're concerned about memory issues or cognitive changes, taking a free online assessment for Mild Cognitive Impairment can help you understand whether your symptoms warrant a medical evaluation.
This is not a diagnosis—but it can help you decide whether medical evaluation is appropriate.
Mood disorders can strongly affect:
In fact, untreated depression is one of the most common causes of perceived "cognitive decline."
Poor sleep, sleep apnea, or chronic insomnia can cause:
Sleep problems are extremely common—and very treatable.
Brain function can be affected by:
These conditions are far more common than CTE—and often reversible.
Having a concussion history does not automatically mean you will develop CTE.
Many people with prior concussions experience:
Research shows that most people with concussions do not go on to develop CTE.
While panic isn't helpful, certain patterns deserve prompt medical evaluation:
If you experience any suicidal thoughts, severe behavioral changes, or sudden neurological symptoms, seek immediate medical care.
CTE is serious—but so are many other brain-related conditions.
Even though CTE cannot be definitively diagnosed during life, doctors can:
The goal is not just to "rule in" CTE—it's to rule out treatable causes first.
There is currently no cure for CTE. Treatment focuses on symptom management:
Because symptoms overlap with other neurological and psychiatric conditions, many treatments used for those conditions can help.
Whether your symptoms are due to CTE, MCI, depression, or stress, these steps are medically supported:
Heavy alcohol use can mimic or worsen cognitive decline.
Depression and anxiety treatment can dramatically improve cognitive function.
It's worth saying clearly:
Constantly worrying that you have CTE can amplify normal cognitive lapses.
Stress increases cortisol levels, which directly affects memory and focus. The more you monitor your thinking for errors, the more errors you notice.
That doesn't mean your symptoms aren't real. It means anxiety can intensify them.
Research suggests:
There is still much we do not know.
That uncertainty can be uncomfortable—but it also means assumptions should be avoided.
Seek immediate medical attention if you experience:
These could indicate serious or life-threatening conditions.
CTE is real.
CTE is serious.
But CTE is also relatively rare compared to other causes of cognitive and mood symptoms.
Most people worried about CTE are experiencing one of the following:
If your brain feels like it's struggling, that's something to take seriously—but not something to panic about.
The smartest next step isn't guessing.
It's getting evaluated.
And most importantly:
If you are concerned about anything that could be serious or life-threatening, speak to a doctor immediately. Early evaluation is always better than waiting.
Your brain is important.
So is getting accurate information.
(References)
* Mez, J., Daneshvar, D. H., Kiernan, P. T., Abdolmohammadi, B., Alosco, P. A., Christensen, J., ... & McKee, A. C. (2020). Clinicopathological Evaluation of Chronic Traumatic Encephalopathy. *Annals of Neurology, 88*(6), 1162-1174. https://pubmed.ncbi.nlm.nih.gov/32822161/
* Alosco, P. A., & McKee, A. C. (2019). Chronic traumatic encephalopathy. *Handbook of Clinical Neurology, 167*, 239-250. https://pubmed.ncbi.nlm.nih.gov/31727289/
* Iverson, G. L., Gardner, A. J., & Zafonte, R. D. (2021). Mild traumatic brain injury and the risk of chronic traumatic encephalopathy. *JAMA Neurology, 78*(1), 101-106. https://pubmed.ncbi.nlm.nih.gov/33074272/
* Cherry, J. D., & McKee, A. C. (2020). The pathophysiology and experimental therapeutics of chronic traumatic encephalopathy. *Experimental Neurology, 329*, 113302. https://pubmed.ncbi.nlm.nih.gov/32188689/
* Tagge, C. A., Fisher, A. M., Mina, A., & Nudo, R. J. (2018). Neuroimaging of chronic traumatic encephalopathy. *Journal of Clinical Imaging Science, 8*(3), 74-83. https://pubmed.ncbi.nlm.nih.gov/30505436/
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.