Doctors Note Logo

Published on: 2/27/2026

Is it CTE? Why Your Brain is Changing & Medically Approved Next Steps

CTE is linked to repeated head impacts but cannot be diagnosed in living people, and similar memory, mood, and thinking changes are often caused by treatable issues like depression, sleep disorders including apnea, vitamin or thyroid problems, or post concussion syndrome.

Medically approved next steps include seeing a doctor for a full evaluation with labs and neuropsych testing, considering MRI to rule out other causes, treating what is treatable, and seeking urgent care for red flag symptoms. There are several factors to consider, so see the complete guidance below.

answer background

Explanation

Is It CTE? Why Your Brain Is Changing & Medically Approved Next Steps

If you've noticed changes in your memory, mood, or thinking—especially after repeated head injuries—you may be wondering: Is it CTE?

Understanding the CTE meaning and what it does (and does not) explain is an important first step. Let's walk through what CTE really is, how it's diagnosed, what symptoms to watch for, and what you can do next.


What Is the Meaning of CTE?

CTE meaning: Chronic Traumatic Encephalopathy.

CTE is a progressive brain disease linked to repeated head impacts, including concussions and even subconcussive blows (hits that don't cause obvious symptoms).

Over time, repeated trauma may lead to:

  • Abnormal buildup of a protein called tau
  • Gradual brain tissue damage
  • Changes in thinking, behavior, and mood

CTE has been most commonly studied in:

  • Contact sport athletes (football, hockey, boxing, soccer)
  • Military veterans exposed to blast injuries
  • Individuals with repeated head trauma

However, not everyone with repeated concussions develops CTE. That's important to understand.


A Critical Fact: CTE Can Only Be Diagnosed After Death

One of the most misunderstood aspects of CTE meaning is diagnosis.

At this time:

  • CTE cannot be definitively diagnosed in a living person
  • It is confirmed through brain tissue examination after death

Doctors may suspect CTE based on symptoms and history of repetitive head trauma, but there is currently no approved brain scan or blood test that confirms it during life.

So if you are asking, "Is it CTE?" the honest answer is: No one can say for certain while you are alive.

That does not mean your symptoms aren't real. It simply means other treatable causes must be evaluated first.


Symptoms Commonly Associated With CTE

Symptoms often develop years—or even decades—after repeated head injuries.

They may include:

Cognitive (Thinking) Changes

  • Memory loss
  • Difficulty concentrating
  • Poor judgment
  • Slowed thinking
  • Confusion

Emotional & Behavioral Changes

  • Depression
  • Anxiety
  • Irritability
  • Aggression
  • Impulsivity
  • Mood swings

Later-Stage Symptoms

  • Dementia
  • Trouble speaking
  • Movement problems (similar to Parkinson's disease)

Symptoms tend to worsen gradually over time. However, many of these symptoms can also be caused by:

  • Depression
  • Anxiety disorders
  • Thyroid problems
  • Vitamin deficiencies
  • Sleep disorders
  • Medication side effects
  • Post-concussion syndrome
  • Early Alzheimer's disease
  • Substance use

That's why medical evaluation is essential.


Why Your Brain May Be Changing (Even If It's Not CTE)

If you're noticing mental changes, here are more common and often treatable explanations:

1. Post-Concussion Syndrome

Symptoms can persist for months or longer after a concussion:

  • Brain fog
  • Headaches
  • Light sensitivity
  • Mood changes

This does not automatically mean CTE.

2. Depression or Anxiety

Both can cause:

  • Memory problems
  • Poor concentration
  • Slowed thinking
  • Emotional changes

Many people mistake depression-related cognitive symptoms for dementia.

3. Sleep Problems

Poor sleep alone can cause:

  • Brain fog
  • Irritability
  • Memory lapses
  • Reduced focus

Sleep apnea, in particular, is commonly missed.

4. Hormonal or Metabolic Conditions

  • Thyroid disorders
  • Low vitamin B12
  • Low testosterone
  • Blood sugar imbalances

These are medically treatable.

5. Normal Aging

Some slowing in recall and multitasking is normal. Severe or progressive decline is not.


Who Is at Higher Risk for CTE?

Based on current research, higher risk is associated with:

  • Long history of contact sports (especially tackle football)
  • Repeated concussions
  • Early age of first exposure to repetitive head impacts
  • Military blast exposure
  • Multiple years of high-impact play

But risk does not equal certainty.

Many former athletes never develop significant cognitive decline.


When to Take Symptoms Seriously

You should seek medical attention promptly if you experience:

  • Sudden confusion
  • Severe headache
  • Weakness on one side of the body
  • Slurred speech
  • Vision changes
  • Seizures
  • Suicidal thoughts
  • Rapid personality changes

These can signal stroke, bleeding in the brain, or other urgent conditions.

If something feels dramatically wrong, don't wait—seek emergency care.


A Practical First Step: Check Your Symptoms

If you're experiencing confusion, memory problems, personality changes, or other signs of alteration in mental status, a free AI-powered symptom checker can help you understand what might be happening and how urgently you need care.

This can help you:

  • Clarify your symptoms
  • Understand possible causes
  • Decide how urgently to seek care

It's not a diagnosis—but it can guide your next step.


Medically Approved Next Steps

If you're concerned about possible CTE or brain changes, here's what doctors typically recommend:

1. Schedule a Medical Evaluation

Start with a primary care doctor or neurologist. They may:

  • Review your concussion history
  • Perform neurological exams
  • Order cognitive testing
  • Check labs (thyroid, B12, hormones)
  • Review medications

Be honest about:

  • Mood changes
  • Substance use
  • Sleep issues
  • Suicidal thoughts

These details matter.


2. Get Neuropsychological Testing

This detailed cognitive testing measures:

  • Memory
  • Processing speed
  • Attention
  • Executive function

It helps determine:

  • Whether impairment is present
  • How severe it is
  • What type of pattern you show

Patterns can sometimes suggest depression vs. neurodegenerative disease.


3. Brain Imaging (If Indicated)

Doctors may order:

  • MRI scans to look for structural changes
  • Imaging to rule out tumors, strokes, or bleeding

Imaging does not confirm CTE but can rule out other causes.


4. Treat What Is Treatable

Even if CTE is suspected, many symptoms are manageable:

  • Depression: Therapy + medication
  • Anxiety: Cognitive behavioral therapy
  • Sleep apnea: CPAP treatment
  • Cognitive rehab: Structured brain training
  • Exercise: Improves brain health
  • Anti-inflammatory lifestyle: Diet, sleep, stress control

Addressing these can significantly improve quality of life.


What Research Says About CTE

Current scientific consensus:

  • CTE is linked to repeated head trauma.
  • It is associated with abnormal tau protein buildup.
  • Symptoms often include mood and cognitive changes.
  • It is still an evolving area of research.
  • Many unanswered questions remain.

Researchers are actively studying:

  • Blood biomarkers
  • Advanced brain scans
  • Prevention strategies

But at present, prevention of repeated head injury remains the most effective strategy.


How to Protect Your Brain Moving Forward

Whether or not CTE is present, these steps support brain health:

  • Avoid additional head injuries
  • Treat depression early
  • Prioritize sleep (7–9 hours nightly)
  • Exercise regularly (aerobic activity supports brain function)
  • Eat a Mediterranean-style diet
  • Manage blood pressure, cholesterol, and blood sugar
  • Stay socially engaged
  • Keep mentally active

Brain health is cumulative. What you do now still matters.


The Bottom Line on CTE Meaning

When people search for CTE meaning, what they're often really asking is:

"Are my brain changes permanent?"

The honest answer:

  • CTE is a real condition linked to repeated head trauma.
  • It cannot currently be diagnosed in living people.
  • Many symptoms attributed to CTE have other, treatable causes.
  • Early evaluation gives you the best chance to improve symptoms.

If you are experiencing cognitive decline, mood changes, or altered thinking, do not ignore it—but do not assume the worst either.

Start with:

  • A structured symptom review
  • A medical appointment
  • A full evaluation

And most importantly:

Speak to a doctor promptly about any symptoms that could be life‑threatening, rapidly worsening, or affecting your safety or the safety of others.

You deserve clarity, not guesswork.

(References)

  • * Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma. Brain. 2019;142(7):1858-1875. doi:10.1093/brain/awz123.

  • * Alosco ML, Mez J, Daneshvar DH, et al. The diagnosis of chronic traumatic encephalopathy: a review. Alzheimers Dement (N Y). 2022;8(1):e12270. Published 2022 Mar 30. doi:10.1002/adno.202270.

  • * Mez J, Daneshvar DH, Kiernan PT, et al. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017;318(4):360-370. doi:10.1001/jama.2017.8334.

  • * Lucke-Wold BP, Turner RC, Logie TJ, et al. Therapeutic advances in chronic traumatic encephalopathy. J Clin Neurosci. 2018;51:1-9. doi:10.1016/j.jocn.2018.01.036.

  • * McKee AC, Stein TD, Nowinski JH, et al. The neuropathology of chronic traumatic encephalopathy: a review. J Neuropathol Exp Neurol. 2013;72(2):128-146. doi:10.1097/NEN.0b013e318280f5d8.

Thinking about asking ChatGPT?Ask me instead

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Learn more about symptoms

Alteration in mental status

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.