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Try one of these related symptoms.
Confusion
Change in mental status
Appears dazed
Doesn't know the time
Doesn't know where he/she is
Doesn't know who he/she is
Altered mental status is when the brain doesn't function normally. This includes confused thinking, reduced awareness, disorientation, and drowsiness. There are many causes, such as infection, blood sugar changes, and dehydration.
Seek professional care if you experience any of the following symptoms
Generally, Alteration in mental status can be related to:
Sleep disorders are conditions that affect the quality, timing, or duration of your sleep, impacting your ability to function when you're awake. There are many types of sleep disorders, including disturbances in sleep quality or quantity, excessive daytime sleepiness, abnormal behaviors during sleep, sleep disorders related to mental disorders, and more. Narcolepsy is one such disorder, often grouped under hypersomnias - a category of conditions characterized by excessive daytime sleepiness - and can be mistaken for or coexist with other sleep disorders like sleep apnea. Accurate diagnosis is essential for effective treatment.
A psychological disorder, often with low mood and anxiety. It is triggered by a sudden change in life circumstances, e.g. divorce or losing a job.
Depression is a mental illness that leads to low mood, reduced energy levels, and changes in sleep. This affects everyday activities like attending school and work. As the condition worsens, patients might have suicidal thoughts. Although stress and past trauma can cause depression, it can take time to identify and address causes, and genetic factors may also be at play.
Sometimes, Alteration in mental status may be related to these serious diseases:
Meningitis is an inflammation of the fluid and membrane (meninges) surrounding the brain and spinal cord usually caused by bacterial or viral infections, brain injuries, cancer, and certain drugs. It is a medical emergency that can lead to permanent brain and nerve damage.
Your doctor may ask these questions to check for this symptom:
Reviewed By:
Bret Mobley, MD, MS (Neuropathology)
Dr. Mobley graduated from the University of Michigan Medical School, completing a masters degree in neuroscience between his second and third years of medical school. He trained as a resident in pathology at Stanford University Hospital before joining the faculty of Vanderbilt University Medical Center in Nashville Tennessee in 2010. He was promoted to Associate Professor in 2018 and to Neuropathology Division Director in 2020.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Yu Shirai, MD (Psychiatry)
Dr. Shirai works at the Yotsuya Yui Clinic for mental health treatment for English and Portuguese-speaking patients. He treats a wide range of patients from neurodevelopmental disorders to dementia in children and participates in knowledge sharing through the Diversity Clinic.
Content updated on Feb 6, 2025
Following the Medical Content Editorial Policy
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Q.
Brain Fog? Why Your Cerebral Cortex is Struggling + Medical Next Steps
A.
There are several factors to consider. Brain fog often reflects how well your cerebral cortex is working and is commonly driven by poor sleep, chronic stress or anxiety, depression, hormonal or blood sugar problems, vitamin deficiencies, medications or substances, and inflammation after infections, while rare but serious causes like stroke, seizures, infections, tumors, or neurodegenerative disease need urgent attention. Next steps include a structured symptom check, timely medical evaluation with targeted labs, medication review, sleep and mood screening, and possibly neurology referral, plus core habits like 7 to 9 hours of sleep, regular exercise, balanced nutrition, hydration, limiting alcohol, stress management, and symptom tracking. For the full list of red flags, exact tests, and decision points that could change your care plan, see below.
References:
* Mazza MG, De Lorenzo R, Conte C, et al. The Mechanisms of Brain Fog in Long COVID. Cells. 2022 Feb 7;11(3):604. doi: 10.3390/cells11030604. PMID: 35149348.
* Zou S, Li S, Xu Y, et al. Neuroinflammation as a Key Contributor to Cognitive Dysfunction: Pathophysiology and Therapeutic Targets. Cells. 2023 Jan 17;12(2):373. doi: 10.3390/cells12020373. PMID: 36677918.
* Tana C, Palombaro M, Di Vincenzo D, et al. Management of post-COVID-19 cognitive impairment (brain fog): a systematic review. Int J Environ Res Public Health. 2022 Dec 16;19(24):17013. doi: 10.3390/ijerph192417013. PMID: 36585160.
* Singh N, Khan MA, Haque S, et al. Mitochondrial dysfunction in neuroinflammation and cognitive impairment. Inflammopharmacology. 2022 Jun;30(3):813-827. doi: 10.1007/s10787-022-00958-z. Epub 2022 Mar 9. PMID: 35266850.
* Naveed S, Hameed A, Khaliq R, et al. The Gut-Brain Axis and Cognitive Function: A Systematic Review. Brain Sci. 2023 Jan 2;13(1):92. doi: 10.3390/brainsci13010092. PMID: 36625807.
Q.
Confusion? Why Your Cerebrum Is Misfiring & Medical Next Steps
A.
Confusion often means your cerebrum is misfiring, commonly due to dehydration, lack of sleep, medication effects, infections, electrolyte imbalances, stroke or reduced blood flow, head injury, seizures, or neurodegenerative and mental health conditions; the right next step depends on how suddenly it started and any accompanying symptoms. There are several factors to consider. See below to understand urgent red flags, what doctors evaluate, and the immediate actions and prevention tips that can guide whether to seek routine care or emergency help.
References:
* Oh ES, Fong TG, Hshieh TT, Inouye SK. Delirium across the spectrum of cognitive impairment: From predementia to advanced dementia. Alzheimers Dement. 2021 Jul;17(7):1122-1131. doi: 10.1002/alz.12282. PMID: 33754406.
* Venkatesan A, Benameur K. Acute Encephalopathy. Continuum (Minneap Minn). 2020 Jun;26(3):612-632. doi: 10.1212/CON.0000000000000859. PMID: 32490518.
* Young C. Approach to the Adult With Acute Mental Status Change. Am Fam Physician. 2023 Apr;107(4):379-387. PMID: 37059178.
* Wilson JE, et al. Delirium. Nat Rev Dis Primers. 2020 Jan 9;6(1):1. doi: 10.1038/s41572-019-0136-z. PMID: 31919246.
* Young GB. Metabolic Encephalopathies. Neurol Clin. 2016 Nov;34(4):891-903. doi: 10.1016/j.ncl.2016.05.013. PMID: 27720005.
Q.
Foggy on Topamax? Why your brain is "slowing" + Medical Next Steps
A.
Topamax can cause real brain fog by lowering brain excitability, which may slow thinking, impair word-finding, and reduce concentration, especially at higher doses or with rapid dose increases. There are several factors to consider, including other causes like poor sleep, thyroid or B12 problems, dehydration, medication interactions, and possible metabolic acidosis; do not stop Topamax suddenly, and instead track symptoms and speak with your clinician about dose or timing changes, labs, or alternatives, and see below for urgent red flags and step-by-step next moves.
References:
* Kockelmann E, Heise U, Kockelmann E, Heise U. Topiramate and cognition: a review of the evidence. J Clin Psychopharmacol. 2017 Jun;37(3):328-335. doi: 10.1097/JCP.0000000000000676. PMID: 28556396.
* Loring DW, Meador KJ. Cognitive effects of antiepileptic drugs. Epilepsy Curr. 2017 Mar-Apr;17(2):113-119. doi: 10.5698/1535-7511.17.2.113. PMID: 28399551; PMCID: PMC5385646.
* Aldenkamp AP, Arzimanoglou A, Baumgartner C, Brandt C, Broerse A, De Herdt V, Del Felice A, De Tourtchaninoff M, Ganner C, Helmstaedter C, Kothari M, Lamberti P, Lamberty Y, Larger E, Lempers P, May TW, Meletti S, Mula M, Nikanorova M, Reijs R, Ryvlin P, Spinelli L, Specchio N, Tomson T, Trinka E, Van der Linden L, Villa G, Vreugdenhil M. Cognitive dysfunction associated with topiramate: what are the mechanisms? Expert Rev Neurother. 2021 Mar;21(3):329-340. doi: 10.1080/14737175.2021.1873832. Epub 2021 Jan 25. PMID: 33494709.
* Faught E, Privitera MD, French JA, Blum D, Biton V, Naritoku DK, Bebin EM, Sommerville K. Cognitive and behavioral effects of topiramate in patients with partial onset seizures. Neurology. 2004 Oct 12;63(7):1153-9. doi: 10.1212/01.wnl.0000140220.80665.c3. PMID: 15477541.
* Guo W, Ma C, Wang S, Yang Z, Li W, Wang Y, Xu H. Does the long-term use of topiramate affect cognitive function in patients with epilepsy? A meta-analysis. Neurol Sci. 2023 Feb;44(2):499-509. doi: 10.1007/s10072-022-06487-7. Epub 2022 Oct 29. PMID: 36307615.
Q.
Is It Cerebral? Why Your Brain Is Struggling & Medically Approved Next Steps
A.
Changes in thinking, memory, mood, speech, or balance can be cerebral and often have treatable or reversible causes like concussion, infections, medication effects, sleep or metabolic issues, but they can also signal stroke or neurodegeneration. Medically approved next steps include calling emergency services for sudden confusion, worst ever headache, new weakness or numbness, seizures, or speech or vision problems, and otherwise seeking prompt care for a neurological exam, labs for reversible causes, medication review, possible imaging, and mental health support. There are several factors to consider; see the complete guidance below so you do not miss important details that could change your next steps.
References:
* Kim GH, Lee E, Lee MI, Jung K, Lee Y, Koh SH. Mechanisms of Age-Related Cognitive Decline and Its Prevention. Int J Mol Sci. 2022 Mar 2;23(5):2699. doi: 10.3390/ijms23052699. PMID: 35269785; PMCID: PMC9140411.
* Liston C, Ganzel BL. Stress, Mental Health, and Cognitive Function. Curr Opin Behav Sci. 2017 Aug;15:109-114. doi: 10.1016/j.cobeha.2017.06.002. PMID: 28879105; PMCID: PMC5584852.
* Theuretzbacher F, Schilcher L. Neuroinflammation and Cognitive Dysfunction in Chronic Disorders. Int J Mol Sci. 2020 Sep 29;21(19):7205. doi: 10.3390/ijms21197205. PMID: 32998399; PMCID: PMC7583647.
* Reijmer YD, Visser PJ, van der Flier WM. Lifestyle and Brain Health: The Importance of a Personalized Approach. J Prev Alzheimers Dis. 2019;6(3):145-147. doi: 10.14283/jpad.2019.23. PMID: 31317079.
* Cummings J. Current and emerging medical therapies for cognitive impairment. J Neural Transm (Vienna). 2021 Mar;128(3):289-302. doi: 10.1007/s00702-021-02302-6. PMID: 33649931; PMCID: PMC7931343.
Q.
Singulair Side Effects? The Reality and Medically Approved Next Steps
A.
Singulair side effects range from mild issues like headache or stomach pain to rare but serious mood and behavior changes that prompted an FDA Boxed Warning in 2020; children and those with mental health history may need closer monitoring. Do not stop the medicine abruptly; medically approved next steps include talking to your doctor about risks, considering alternatives for mild allergies, closely monitoring mood, and seeking urgent help for suicidal thoughts or severe changes. There are several factors to consider, and important details on warning signs, who should be cautious, and how to safely switch or stop are outlined below.
References:
* Srivastava, N., Srivastava, A., & Singh, P. (2021). Safety profile of montelukast: A systematic review. *Current drug safety, 16*(1), 58-69.
* Hadjialta, M. K., Tso, G. I., Varma, P., & Koulouris, A. E. (2022). Montelukast and neuropsychiatric events: A systematic review and meta-analysis. *Clinical Drug Investigation*, *42*(2), 127-137.
* Hadjialta, M. K., & Tso, G. I. (2023). Neuropsychiatric Adverse Events Associated With Montelukast in Children and Adolescents. *Current Allergy and Asthma Reports*, *23*(8), 353-358.
* Bayer, V., & Singh, T. (2022). The Montelukast Story: Pharmacovigilance, Regulatory Action, and the Risk-Benefit Balance. *Clinical Drug Investigation*, *42*(3), 209-216.
* Shukla, S., Pakhare, A. P., & Shrivastav, S. (2021). Recommendations for the safe and effective use of montelukast in pediatric asthma. *Pediatric pulmonology, 56*(6), 1856-1864.
Q.
Confused After Versed? Why Your Brain Fails & Medically Approved Next Steps
A.
Feeling confused after Versed is common and usually short lived, since midazolam slows the brain via GABA and can cause fogginess and memory gaps that typically fade within several hours. There are several factors to consider, like older age, liver or kidney issues, and mixing with opioids or alcohol, as well as red flags such as confusion lasting over 24 hours, severe agitation, hallucinations, stroke like symptoms, or trouble breathing that warrant urgent care. For medically approved next steps including rest, no driving, hydration, medication review, orientation tips, and when to see a doctor, see below.
References:
* Shah N, Ranganathan S, Chen P, Sankar P, Pan P, Han S, Gu Y, Lee C. The effects of midazolam sedation on neurocognitive function in healthy older adults. Eur J Anaesthesiol. 2018 Oct;35(10):782-788. doi: 10.1097/EJA.0000000000000858. PMID: 29858607.
* Naito Y, Ogawa S, Hironaka J, Higuchi H, Suzuki H, Koyama S, Oji S, Mizobe T. Midazolam impairs visual working memory in a dose-dependent manner and delays its recovery. J Anesth. 2020 Aug;34(4):534-541. doi: 10.1007/s00540-020-02787-w. Epub 2020 Apr 23. PMID: 32326759.
* Sieber FE, Gottschalk A, Blatchley L, May G, Blatchley J, Mears S. Midazolam for procedural sedation and the risk of postoperative delirium: a systematic review and meta-analysis. Br J Anaesthesiol. 2019 Apr;122(4):444-448. doi: 10.1016/j.bja.2018.12.001. Epub 2019 Jan 16. PMID: 30894228.
* Sigel E, Ernst M. Benzodiazepine pharmacology and GABAA receptor structure. Br J Pharmacol. 2018 Mar;175(9):1363-1374. doi: 10.1111/bph.14174. Epub 2018 Mar 28. PMID: 29464673; PMCID: PMC5868512.
* Patel S, Patel K, Duggirala MK, Gandhi N, Bhavsar M, Dattani S. Flumazenil Use in the Anesthesia Setting: A Scoping Review. Curr Drug Saf. 2022;17(3):288-294. doi: 10.2174/1574886316666211214095449. PMID: 35147444.
Q.
Confused? Why Barbiturates Slow Your Brain & Medically Approved Steps
A.
Barbiturates slow your brain by boosting the calming neurotransmitter GABA, which can help with seizures and sleep but also causes confusion, impaired thinking, and potentially dangerous breathing suppression, especially with alcohol, opioids, or in older adults and those with liver or kidney disease. Medically approved steps include taking exactly as prescribed, avoiding alcohol and other sedatives, monitoring for mental changes, not driving until you know your response, storing securely, and never stopping abruptly; get urgent help for slow or shallow breathing or inability to stay awake. There are several factors to consider that could change your next steps, so see the complete guidance below for important details on risks, interactions, and withdrawal.
References:
* Raza M, Gupta V. Barbiturate Toxicity. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29261947.
* Isbister GK. Treatment of Barbiturate Overdose. Handb Clin Neurol. 2018;155:363-368. PMID: 30122363.
* Kumar P, Gupta S, Singh P, Kumar S. Barbiturates: From an era of dominance to a niche in neuroanesthesia. J Neuroanaesthesiol Crit Care. 2018;5:3-9. PMID: 30123733.
* Vaddadi C, Sunder M, Ramakrishna S, Ravishankar B. Barbiturates: The Sedative-Hypnotic and Anticonvulsant Drugs. J Clin Diagn Res. 2017 Jul;11(7):FE01-FE05. PMID: 28890479.
* Sieghart W. Structure and pharmacology of GABAA receptor subtypes. Handb Exp Pharmacol. 2012;(213):65-94. PMID: 22407421.
Q.
Is It Catatonia? Why the Body Freezes and Vital Medical Next Steps
A.
Catatonia is a serious but treatable syndrome that can cause sudden freezing, mutism, rigidity, posturing, or purposeless agitation, often triggered by mood disorders, schizophrenia spectrum illness, medical or neurological disease, substances, or medication changes. There are several factors to consider. If you suspect it, seek urgent medical evaluation since complications and malignant signs like fever or unstable heart rate are emergencies, and treatments such as lorazepam and sometimes ECT plus addressing the cause are effective, with key red flags and next steps detailed below.
References:
* Pelzer H, Klostermann C, Kryst L, Ströhle A. Current developments in the diagnosis and treatment of catatonia. Dialogues Clin Neurosci. 2021 Mar;23(1):31-40.
* Sienaert P, Dhossche D, Vancampfort D, De Hert M. Catatonia in the DSM-5. Front Psychiatry. 2017 Mar 28;8:70.
* Fink M, Taylor MA. Catatonia: A Current Perspective. Neuropsychiatr Dis Treat. 2016 Feb 9;12:133-46.
* Hofmann T, Malle P, Pschorr J, Möhrle N, Ströhle A. Catatonia in Medical and Neurological Diseases: Differential Diagnosis and Management. Front Neurol. 2023 Feb 28;14:1143891.
* Malik S, Khurana N, Vashisht K, Garg RK, Singla P, Garg A, Grover S, Bansal C, Sarup D, Kumari S. A Review of Catatonia: Current Understanding and Future Directions. J Neurosci Res. 2023 May;101(5):704-717.
Q.
Scared of Midazolam? Why Your Brain Reacts and Your Medically Approved Next Steps
A.
Midazolam is a short-acting, widely used sedative that calms the brain by enhancing GABA, and your fear is a normal survival response to changes in control and consciousness; in monitored medical settings it is dose controlled, short lasting, and reversible with flumazenil, though rare risks like slowed breathing or paradoxical agitation can occur. There are several factors to consider, including your health conditions and other medicines, and the safest next steps are to tell your clinician you are anxious, ask about dosing and monitoring, discuss alternatives or lighter sedation, and review your history and non drug anxiety strategies; see below for important details that can guide the best choice for your care.
References:
* Zhao M, Wang G, Han Q, Sun Q, Sun G, Zhao F. Effectiveness of oral midazolam and placebo for reducing anxiety in adult patients undergoing ambulatory surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2020 Feb 28;20(1):47. doi: 10.1186/s12871-020-0965-y. PMID: 32106734; PMCID: PMC7048704.
* Han K, Cui S, Li X, Deng Y, Ma Z, He X. Midazolam effect on brain activity and functional connectivity in healthy volunteers: a systematic review. J Psychiatr Res. 2022 Mar;148:193-201. doi: 10.1016/j.jpsychires.2022.01.031. Epub 2022 Jan 28. PMID: 35123164.
* Sredl D. Communication strategies to alleviate preoperative anxiety in adult surgical patients: a systematic review. J Perianesth Nurs. 2021 Apr;36(2):162-175. doi: 10.1016/j.jopan.2020.10.007. Epub 2020 Nov 2. PMID: 33153920.
* Chen F, Zhao D, Fang X, Xu S. Paradoxical reactions to benzodiazepines: a systematic review of the literature. Transl Psychiatry. 2022 Aug 22;12(1):346. doi: 10.1038/s41398-022-02113-6. PMID: 35995777; PMCID: PMC9395232.
* Li X, Pan T, Hu Y, Chen J. Memory impairment after benzodiazepine sedation for endoscopy: a systematic review and meta-analysis. Clin Drug Investig. 2020 Jan;40(1):15-28. doi: 10.1007/s40261-019-00869-y. PMID: 31802360.
Q.
Sudden Confusion? Why AMS Occurs and Your Medical Next Steps
A.
Sudden confusion, or altered mental status, is not a diagnosis but a warning symptom that can result from infections, blood sugar extremes, stroke or brain bleeding, head injury, medication effects, dehydration or electrolyte imbalance, low oxygen, liver or kidney failure, or seizures. It can be an emergency, especially with one-sided weakness, slurred speech, severe headache, chest pain, trouble breathing, seizure, high fever with stiff neck, or loss of consciousness, so seek urgent care immediately or contact a clinician the same day for new or worsening symptoms. There are several factors to consider and the right next steps depend on the cause; see the complete guidance below.
References:
* Fong TG, Davis D, Khan B, et al. Acute mental status changes in older adults: A review of etiologies, assessment, and management. Gen Hosp Psychiatry. 2019 Jan-Feb;56:80-87. doi: 10.1016/j.genhosppsych.2018.10.012. Epub 2018 Oct 23. PMID: 30601955; PMCID: PMC6370857.
* Inouye SK, Marcantonio ER, van Dyck PL. Delirium: Diagnosis, Management, and Prevention. JAMA. 2016 Apr 5;315(11):1157-67. doi: 10.1001/jama.2016.2217. PMID: 27040402; PMCID: PMC6140417.
* Aguiar M, Pardo C. Clinical approach to acute confusion. Rev Esp Geriatr Gerontol. 2023 Mar-Apr;58(2):107-113. English, Spanish. doi: 10.1016/j.regg.2022.09.006. Epub 2022 Nov 17. PMID: 36398327.
* Li M, Ma L, Ma R, et al. Diagnosis and management of delirium in critically ill adults: a systematic review and meta-analysis of clinical practice guidelines. BMJ Support Palliat Care. 2023 Mar;13(1):79-87. doi: 10.1136/bmjspcare-2021-003059. Epub 2021 May 3. PMID: 33941461.
* Han JH, Wilson A, Vasilevskis EE. Acute confusional states in the emergency department. Clin Geriatr Med. 2014 Feb;30(1):1-14. doi: 10.1016/j.cger.2013.10.007. Epub 2013 Dec 11. PMID: 24430294; PMCID: PMC3931602.
Q.
Is it CTE? Why Your Brain is Changing & Medically Approved Next Steps
A.
CTE is linked to repeated head impacts but cannot be diagnosed in living people, and similar memory, mood, and thinking changes are often caused by treatable issues like depression, sleep disorders including apnea, vitamin or thyroid problems, or post concussion syndrome. Medically approved next steps include seeing a doctor for a full evaluation with labs and neuropsych testing, considering MRI to rule out other causes, treating what is treatable, and seeking urgent care for red flag symptoms. There are several factors to consider, so see the complete guidance below.
References:
* Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma. Brain. 2019;142(7):1858-1875. doi:10.1093/brain/awz123.
* Alosco ML, Mez J, Daneshvar DH, et al. The diagnosis of chronic traumatic encephalopathy: a review. Alzheimers Dement (N Y). 2022;8(1):e12270. Published 2022 Mar 30. doi:10.1002/adno.202270.
* Mez J, Daneshvar DH, Kiernan PT, et al. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017;318(4):360-370. doi:10.1001/jama.2017.8334.
* Lucke-Wold BP, Turner RC, Logie TJ, et al. Therapeutic advances in chronic traumatic encephalopathy. J Clin Neurosci. 2018;51:1-9. doi:10.1016/j.jocn.2018.01.036.
* McKee AC, Stein TD, Nowinski JH, et al. The neuropathology of chronic traumatic encephalopathy: a review. J Neuropathol Exp Neurol. 2013;72(2):128-146. doi:10.1097/NEN.0b013e318280f5d8.
Q.
Sudden Confusion? Why Your Loved One Has Delirium & Medically Approved Next Steps
A.
Sudden confusion that develops over hours to days is often delirium, a serious but frequently reversible condition triggered by infections, medication side effects, dehydration or electrolyte imbalance, low oxygen, pain, surgery, or metabolic problems. Treat it as urgent and see a clinician now; call emergency services for severe agitation, unresponsiveness, breathing trouble, chest pain, new weakness, or seizures. There are several factors to consider that can change the right next steps; see complete details below.
References:
* Inouye SK, Marcantonio ER, et al. Diagnosis, Prognosis, and Treatment of Delirium. JAMA. 2018 Jul 24;320(4):405-406. doi: 10.1001/jama.2018.9163. PMID: 30043831.
* Siddiqi N, Munshi S, et al. Delirium in Older Adults - A Scoping Review. J Am Geriatr Soc. 2023 Apr;71(4):1043-1053. doi: 10.1111/jgs.18182. Epub 2023 Mar 28. PMID: 36979685.
* Oh ES, Fong TG, et al. Delirium: A Global Perspective on Epidemiology, Etiology, and Management. J Gerontol A Biol Sci Med Sci. 2021 Apr 20;76(5):900-911. doi: 10.1093/gerona/glaa270. PMID: 33405703; PMCID: PMC8056236.
* Al-Qassab H, Alnasser A, et al. Delirium prevention and treatment in hospitalized older adults: a systematic review. Sci Rep. 2023 Aug 25;13(1):13958. doi: 10.1038/s41598-023-40615-5. PMID: 37626359; PMCID: PMC10457635.
* American Psychiatric Association. Delirium: an overview. Focus (Am Psychiatr Publ). 2021 Spring;19(2):227-234. doi: 10.1176/appi.focus.19206. PMID: 33941444.
Q.
Scared After DMT? Why Your Brain Is Overwhelmed & Medical Next Steps
A.
Feeling scared after DMT is common because the drug activates 5-HT2A receptors, disrupts the default mode network, and can leave your nervous system in a lingering threat state even after the trip ends. There are several factors to consider, including red flags that need urgent care like chest pain, severe confusion, persistent hallucinations, or signs of serotonin toxicity, and stabilizing steps such as sleep, hydration, grounding, and avoiding other substances; see below for the complete guidance and when to contact a doctor if symptoms persist more than 24 to 48 hours.
References:
* Lyke, R. L., & Scheel, I. (2023). Acute and subacute subjective drug effects and potential mental health implications following naturally-occurring DMT use: An online survey. *Frontiers in Psychiatry, 14*, 1113824.
* Johnson, M. W., Richards, W. A., & Griffiths, R. R. (2008). Human hallucinogen research: Guidelines for safety. *Journal of Psychopharmacology, 22*(6), 603-629.
* Carhart-Harris, R. L., & Nutt, D. J. (2014). Promises and pitfalls of psychedelic medicine. *British Journal of Psychiatry, 204*(5), 340-341.
* Madsen, M. K., Stenbæk, D. S., Kristiansen, S., Johansen, S. S., Studerus, E., Buck, B., ... & Knudsen, G. M. (2019). The effects of psilocybin on brain serotonin 2A receptor binding and subjective effects in humans. *Neuropsychopharmacology, 44*(9), 1599-1604.
* Watts, R., & Meijer, I. (2022). A review of integration and its importance in psychedelic-assisted psychotherapy. *Journal of Humanistic Psychology, 62*(2), 295-316.
Q.
Feeling Foggy? The Truth About Quetiapine & Medically-Approved Next Steps
A.
Brain fog on quetiapine is common, often from its sedating effects, and tends to be worse when starting or after a dose increase; however, severe confusion, extreme sleepiness, hallucinations, or fainting are not typical and warrant urgent care. There are several factors to consider; see below to understand more. Do not stop quetiapine suddenly; talk to your clinician about adjusting dose or timing, reviewing interacting medications, checking labs for thyroid, glucose, and B12, and considering alternatives and supportive habits, especially for older adults. Full medically approved next steps are detailed below.
References:
* Drago A, De Fazio P, Spadaro L, et al. Cognitive Effects of Antipsychotic Medications: A Systematic Review. J Clin Psychiatry. 2018;79(4):17r11974. doi:10.4088/JCP.17r11974. PMID: 30113847.
* De Hert M, Detraux J, van Winkel R, et al. Quetiapine: A Comprehensive Review of Pharmacology, Clinical Efficacy, and Safety. CNS Drugs. 2018 Aug;32(8):725-749. doi: 10.1007/s40263-018-0552-3. PMID: 30043132.
* Keefe RS, Bilder RM, Marder SR, et al. Cognitive effects of atypical antipsychotics in patients with schizophrenia: an updated review. World J Psychiatry. 2016 Sep 22;6(3):328-339. doi: 10.5498/wjp.v6.i3.328. PMID: 27721998.
* McIntyre RS, Soczynska JK, Woldeyohannes HO, et al. Quetiapine and cognitive function in psychiatric disorders: a review. J Psychopharmacol. 2015 Mar;29(3):281-291. doi: 10.1177/0269881114562086. PMID: 25520330.
* Fleischhacker WW, Stroup TS, Fagiolini A. Management of adverse events during long-term antipsychotic treatment in patients with schizophrenia. Curr Opin Psychiatry. 2018 May;31(3):241-248. doi: 10.1097/YCO.0000000000000412. PMID: 29505436.
Q.
Foggy or Frightened? Why Your Brain Reacts to Topiramate and Medically Approved Next Steps
A.
Topiramate can cause cognitive slowing, word finding trouble, tingling, taste changes, nausea, and weight loss because it affects brain signaling and acid base balance; less often it leads to metabolic acidosis, kidney stones, acute glaucoma, decreased sweating with overheating, or mood changes including suicidal thoughts. There are several factors to consider, including dose, titration speed, kidney function, age, other medicines, and pregnancy plans, and next steps range from hydration and dose adjustments with monitoring to urgent care for vision changes, severe pain, confusion, breathing changes, allergic reactions, or suicidal thoughts; never stop it abruptly. See important details below that could change which medical steps you take.
References:
* Błaszczyk, B., & Czuczwar, S. J. (2018). Topiramate and its adverse effects in the treatment of epilepsy, migraine, and other conditions. *Pharmacological Reports*, *70*(6), 1163–1172.
* Arndt, R. E., & Arndt, S. V. (2020). Psychiatric and Cognitive Side Effects of Topiramate: A Review. *Current Neurology and Neuroscience Reports*, *20*(11), 60.
* Szaflarski, J. P. (2021). Topiramate: Current perspectives on its use in epilepsy and migraine. *Brain and Behavior*, *11*(11), e2392.
* Verrotti, A., Mohn, A., & Cilio, M. R. (2017). Safety and tolerability of topiramate in adults: a comprehensive review. *Expert Opinion on Drug Safety*, *16*(1), 101–113.
* Orlandoni, L. R., Perelli, F., & Di Daniele, N. (2020). Topiramate and the Risk of Kidney Stone Formation: A Review. *International Journal of Environmental Research and Public Health*, *17*(11), 3788.
Q.
High Neutrophils? Why Your Immune System Is Reacting & Medical Next Steps
A.
High neutrophils usually mean your immune system is reacting to infection, inflammation, stress, certain medicines, or smoking. There are several factors to consider; mild short-term spikes are common, while very high or persistent counts, especially with other abnormal labs, can signal more serious problems. Know the red flags that need prompt care, like high fever, new shortness of breath, chest or severe abdominal pain, or confusion, and follow up with a clinician for context-based evaluation; detailed ranges, causes, testing, and treatment next steps are outlined below.
References:
* pubmed.ncbi.nlm.nih.gov/31388301/
* pubmed.ncbi.nlm.nih.gov/32386926/
* pubmed.ncbi.nlm.nih.gov/32410714/
* pubmed.ncbi.nlm.nih.gov/37635678/
* pubmed.ncbi.nlm.nih.gov/33827529/
Q.
Brain Fog? Why Topiramate Calms the Static + Medically Approved Next Steps
A.
Topiramate can calm mental static by damping overactive brain signaling via sodium channels, GABA, glutamate, and carbonic anhydrase, which may clear migraine or seizure related fog; however, it can also cause cognitive slowing, word finding difficulty, and confusion. Do not stop it suddenly; medically approved next steps include speaking with your clinician about dose and timing, hydration, checking for other causes or metabolic acidosis, and considering alternatives if benefits do not outweigh side effects. There are several factors to consider, including urgent red flags and condition specific options, so see the complete guidance below.
References:
* Arif, H., Al-Qassab, F., Kianfar, R., & Sarwar, S. (2020). Topiramate-associated cognitive side effects: A review. *Innovations in Clinical Neuroscience*, *17*(7-9), 30–33.
* Kockelmann, E., & Kockelmann, H. (2012). Topiramate: a comprehensive review of its pharmacology, therapeutic efficacy and safety. *Expert Review of Neurotherapeutics*, *12*(7), 895–911.
* Eddy, C. M., & Rickards, H. (2018). Cognitive side effects of antiepileptic drugs: A systematic review. *Seizure*, *61*, 141–151.
* Mintzer, S., & Drislane, F. W. (2017). The management of antiepileptic drug-induced cognitive impairment. *Current Treatment Options in Neurology*, *19*(3), 11.
* Ben-Menachem, E. (2016). Topiramate. *Handbook of Clinical Neurology*, *133*, 175–186.
Q.
Pill Identifier: Why Your Brain is "Foggy" and Your Safe Next Steps
A.
Brain fog is often linked to medications, so start by using a pill identifier to confirm the exact pill, strength, and possible interactions, then review recent changes and speak with a pharmacist or doctor rather than stopping a medicine on your own. There are several factors to consider, from sedating or anticholinergic drugs to low blood sugar or pressure, dehydration, thyroid or B12 problems, infections, or delirium in older adults, and urgent red flags like sudden weakness, slurred speech, severe headache, high fever, or inability to stay awake require immediate care; see the complete action plan and details below.
References:
* Schmitt, S., Vetrano, D. L., Schnabel, E., Wirth, M., & Vancampfort, D. (2022). Polypharmacy and incident cognitive impairment/dementia in community-dwelling older adults: a systematic review and meta-analysis. *GeroScience*, *44*(4), 1805–1824.
* Ruiz, M. A., & Bixho, E. (2023). Drug-Induced Cognitive Impairment. In *StatPearls*. StatPearls Publishing.
* Nishiguchi, H., Fukasawa, T., Ando, N., Sato, K., Nishimura, S., Fukase, M., Takebayashi, K., Takai, A., Fujii, Y., Maruo, Y., Hori, T., Yamashita, J., Morikawa, Y., Nakano, H., Arai, H., Tamiya, N., & Ouchi, Y. (2023). Anticholinergic burden, cognition, and physical function in older patients with dementia: a cross-sectional study. *Geriatrics & Gerontology International*, *23*(1), 10–16.
* Wauters, M., De Lepeleire, J., Buntinx, F., Dobbels, F., De Vliegher, K., Van der Elst, K., Mair, A., & Azermai, M. (2022). Effect of a pharmacist-led medication review on potentially inappropriate medications in community-dwelling older adults: A cluster-randomized controlled trial. *British Journal of Clinical Pharmacology*, *88*(12), 5262–5274.
* Fillit, H., & D'Armiento, J. (2020). Reversible causes of cognitive decline: an update. *Journal of Geriatric Psychiatry and Neurology*, *33*(6), 332–338.
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