Doctors Note Logo

Back

Published on: 5/6/2025

How Can You Determine If Symptoms Are Due to Fatigue, Depression, or Another Underlying Issue Like Low Testosterone?

Doctors look at a person's history, feelings, and physical signs and use lab tests to decide if fatigue is from depression, low testosterone, or another cause. They ask questions, do physical exams, and sometimes check hormone levels to find out.

answer background

Explanation

When figuring out what is causing fatigue or feeling low, doctors first ask many questions about how you feel day-to-day. They ask if you have problems with sleep, mood changes like sadness or lack of interest in fun things, or if you have other signs that worry you. This helps them see if it might be depression. They also check for symptoms of low testosterone, such as less energy, lower sex drive, or changes in body hair, testicle size, breast size, and muscle strength. If these signs are present, a blood test to measure testosterone levels in the morning is often suggested because hormone levels change during the day. A careful physical exam is done to see if there are any clues of other conditions. Sometimes, fatigue can seem like depression, and low testosterone can also make you feel down. Doctors use tools like questionnaires about depression along with lab tests to help tell them apart. By combining all this information, they can make a more accurate guess if your symptoms come from being tired, feeling depressed, or having a low hormone level.

(References)

  • Maisel P, Baum E, Donner-Banzhoff N. Fatigue as the Chief Complaint–Epidemiology, Causes, Diagnosis, and Treatment. Dtsch Arztebl Int. 2021 Aug 23;118(33-34):566-576. doi: 10.3238/arztebl.m2021.0192. PMID: 34196270; PMCID: PMC8579431.

  • Indirli R, Lanzi V, Arosio M, Mantovani G, Ferrante E. The association of hypogonadism with depression and its treatments. Front Endocrinol (Lausanne). 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437. PMID: 37635965; PMCID: PMC10449581.

  • Määttänen I, Gluschkoff K, Komulainen K, Airaksinen J, Savelieva K, García-Velázquez R, Jokela M. Testosterone and specific symptoms of depression: Evidence from NHANES 2011-2016. Compr Psychoneuroendocrinol. 2021 Mar 10;6:100044. doi: 10.1016/j.cpnec.2021.100044. PMID: 35757365; PMCID: PMC9216439.

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Not sure about the cause of your current symptoms?

AI Symptom Check

Try our AI-based symptom checker

With an easy 3-min questionnaire, you can get a free AI-powered report on possible causes


Tips to try:

  • Provide specific, detailed info about all symptoms you have.
  • Give accurate information about yourself including current conditions.
  • Answer all follow-up questions

Purpose and positioning of servicesUbie Doctor’s Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.