Published on: 6/26/2025
Is there a genetic component to narcolepsy, and can it be inherited?
Narcolepsy has a genetic component and can rarely run in families, but most narcolepsy is not inherited.
Explanation
Narcolepsy has a genetic component and can occasionally run in families, but most narcolepsy is not inherited.
Some Information About Genetics
- HLA Genes: Certain genes, especially some in the HLA (human leukocyte antigen) region, are associated with narcolepsy. These genes play a role in the immune system.
- Family Connections: Most people with narcolepsy do not have a close relative with the condition. This suggests that while genetics are important, they are not the only factor.
Other Possible Factors
- Non-genetic Factors: Some research has suggested prior infection with influenza or streptococcus might play a role in whether or not someone develops narcolepsy. Non-genetic factors might increase the risk of narcolepsy compared to genes.
In summary, while some research has identified a genetic profile associated with narcolepsy, narcolepsy is not inherited most of the time. If you think you might have narcolepsy, a healthcare provider can provide a personalized evaluation for narcolepy. Also, more information about narcolepsy is available at https://sleepeducation.org/sleep-disorders/narcolepsy/.
(References)
- Mignot E. (1998). Genetic and familial aspects of narcolepsy. Neurology, 9484418.
- Miyagawa T, & Tokunaga K. (2019). Genetics of narcolepsy. Human genome variation, 30652006.
- Chabas D, Taheri S, Renier C, & Mignot E. (2003). The genetics of narcolepsy. Annual review of genomics and human genetics, 14527309.
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