Is there a genetic component to prostate cancer risk?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Prostate cancer does have a genetic component and can run in families. Men with a father or brother diagnosed with prostate cancer face roughly double the average risk, and that risk climbs higher when multiple relatives are affected or when diagnoses occurred before age 65. Inherited gene mutations—such as BRCA1, BRCA2, HOXB13, and Lynch syndrome-related genes—can also raise susceptibility.

However, family history is only one piece of the picture. Lifestyle, age, ethnicity, and current symptoms all play a role in your overall risk. If you're noticing changes like frequent urination, difficulty starting or stopping urine flow, pelvic discomfort, or blood in urine, it's worth investigating sooner rather than later. A free, instant, online symptom check can help you understand what your symptoms may mean, whether they align with prostate concerns or something else entirely, and guide your next steps—so you can approach your doctor with clarity and confidence.

Reviewed for medical accuracy: 07/14/2026

Important Next Steps

Discover if genetics raise your prostate cancer risk Learn what may be causing prostate cancer risk See whether prostate cancer risk needs care today Find OTC options for prostate cancer symptoms Find a doctor for prostate cancer concerns Understand medically valid home remedies for prostate health Find out if prostate cancer risk is high

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Explanation

Prostate cancer risk can be influenced by genes. Some families have a higher chance of getting prostate cancer because of these genes.

Genetic Factors

Hereditary Genes: Certain genes passed down in families can make prostate cancer more likely. This means if your dad or grandpa had prostate cancer, you might have a higher risk too.
Specific Genes: Scientists have found some specific genes related to prostate cancer. These genes can affect how cells grow and change.

Why It Matters

Family History: Knowing your family history can help you understand your risk.
Screening: If prostate cancer runs in your family, doctors might check you more often. You can also use a free AI symptom checker to assess your symptoms and determine if you should consult with a healthcare provider.

Understanding these genetic factors helps doctors and families make better choices about screening and prevention.

(References)

Vietri MT, D'Elia G, Caliendo G, Resse M, Casamassimi A, Passariello L, et al. (2021). Hereditary Prostate Cancer: Genes Related, Target .... International journal of molecular sciences, 33916521.
Shevach JW, & Cooney KA. (2025). Genetics of prostate cancer. Clinical advances in hematology & oncology : H&O, 40261162.
Ni Raghallaigh H, & Eeles R. (2022). Genetic predisposition to prostate cancer: an update. Familial cancer, 33486571.

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