Doctors Note Logo

Published on: 2/24/2026

Is Your HDL Cholesterol Low? Why Your Heart is At Risk & Your Medical Next Steps

Low HDL cholesterol raises your risk of heart disease and stroke; low means under 40 mg/dL in men and under 50 mg/dL in women, and it usually has no symptoms so it is found on a blood test.

Next steps center on reducing overall cardiovascular risk with regular exercise, quitting smoking, a Mediterranean style diet, weight loss if needed, and controlling blood sugar and triglycerides, plus talking with your clinician about your 10 year risk and whether statins are indicated even if LDL looks okay. There are several factors to consider; see below for causes, how to prioritize changes, specific targets, and urgent warning signs.

answer background

Explanation

Is Your HDL Cholesterol Low? Why Your Heart Is at Risk & Your Medical Next Steps

If you've been told your HDL cholesterol is low, you might be wondering what that really means for your health. Cholesterol can be confusing, especially when some types are considered "good" and others "bad."

The short answer: Low HDL cholesterol increases your risk of heart disease and stroke. But the good news is that there are clear, evidence-based steps you can take to improve your numbers and protect your heart.

Let's break it down in simple terms.


What Is HDL Cholesterol?

HDL stands for high-density lipoprotein. It's often called the "good" cholesterol because it helps remove excess cholesterol from your bloodstream.

Think of HDL cholesterol as a cleanup crew. It:

  • Picks up extra cholesterol from your arteries
  • Carries it back to the liver
  • Helps your body eliminate it

When HDL levels are healthy, this process lowers the buildup of plaque in your arteries. When HDL cholesterol is low, more cholesterol can stay in the bloodstream, increasing the risk of clogged arteries.


What Is Considered Low HDL Cholesterol?

According to major cardiology guidelines:

  • Men: HDL below 40 mg/dL is considered low
  • Women: HDL below 50 mg/dL is considered low
  • 60 mg/dL or higher is considered protective

Low HDL cholesterol is one component of dyslipidemia, a condition where blood lipid levels are abnormal.

If you're concerned about your cholesterol levels and want to understand your overall risk better, you can use a free AI-powered Dyslipidemia symptom checker to get personalized insights in just a few minutes.


Why Low HDL Cholesterol Puts Your Heart at Risk

Heart disease usually develops over many years. It starts with plaque buildup inside arteries — a process called atherosclerosis.

When HDL cholesterol is low:

  • Less cholesterol is cleared from arteries
  • Plaque buildup can accelerate
  • Arteries become narrowed or stiff
  • Blood flow to the heart or brain can be reduced

This increases your risk of:

  • Heart attack
  • Stroke
  • Peripheral artery disease
  • Coronary artery disease

Low HDL cholesterol often occurs alongside other risk factors, including:

  • High LDL ("bad") cholesterol
  • High triglycerides
  • Type 2 diabetes
  • Obesity
  • Smoking
  • High blood pressure

The combination of these factors significantly raises cardiovascular risk.


What Causes Low HDL Cholesterol?

Several factors can lower HDL cholesterol. Some are genetic, but many are related to lifestyle.

Common causes include:

  • Smoking
  • Lack of physical activity
  • Excess abdominal weight
  • Type 2 diabetes or insulin resistance
  • High triglycerides
  • Diets high in refined carbohydrates and trans fats
  • Certain medications (such as some beta-blockers or anabolic steroids)

Genetics also play a role. Some people naturally have lower HDL cholesterol levels despite healthy habits.


Symptoms of Low HDL Cholesterol

Here's the important part:
Low HDL cholesterol usually causes no symptoms.

You will not "feel" low HDL. Most people only discover it through routine blood work.

That's why regular cholesterol screening is critical — especially if you:

  • Are over age 40
  • Have a family history of heart disease
  • Have diabetes
  • Have high blood pressure
  • Are overweight
  • Smoke

Can You Raise HDL Cholesterol?

Yes — but the approach may not be what you expect.

In the past, doctors focused on raising HDL cholesterol numbers directly. However, research has shown that simply increasing HDL with medication does not always reduce heart attack risk.

Today, the focus is on overall cardiovascular risk reduction, not just boosting HDL levels alone.

That said, certain lifestyle changes can improve HDL cholesterol naturally and reduce heart disease risk overall.


Evidence-Based Ways to Improve HDL Cholesterol

1. Exercise Regularly

Physical activity is one of the most effective ways to raise HDL cholesterol.

Aim for:

  • At least 150 minutes per week of moderate aerobic activity
    (brisk walking, cycling, swimming)

Even modest weight loss combined with exercise can improve HDL levels.


2. Stop Smoking

If you smoke, quitting can significantly increase HDL cholesterol — sometimes within weeks.

Smoking directly lowers HDL and damages blood vessels. Stopping is one of the most powerful heart-protective steps you can take.


3. Improve Your Diet

Focus on heart-healthy eating patterns:

Emphasize:

  • Vegetables and fruits
  • Whole grains
  • Nuts and seeds
  • Olive oil
  • Fatty fish (like salmon or sardines)

Reduce:

  • Trans fats
  • Highly processed foods
  • Refined carbohydrates (white bread, sugary snacks)
  • Sugary beverages

Diets such as the Mediterranean diet are strongly associated with improved cardiovascular outcomes.


4. Maintain a Healthy Weight

Excess abdominal fat is closely linked to low HDL cholesterol.

Even losing 5–10% of body weight can improve lipid levels and insulin sensitivity.


5. Manage Blood Sugar and Triglycerides

If you have diabetes or high triglycerides, managing these conditions can indirectly improve HDL cholesterol and lower heart risk.


Do You Need Medication?

Medication decisions are not based on HDL cholesterol alone.

Your doctor will look at:

  • LDL cholesterol levels
  • Total cholesterol
  • Triglycerides
  • Blood pressure
  • Diabetes status
  • Smoking history
  • Family history
  • Your calculated 10-year cardiovascular risk

In many cases, statins are prescribed if overall heart risk is elevated — even if HDL cholesterol is low but LDL is normal.

Importantly:

  • There is no widely recommended medication whose primary purpose is to raise HDL cholesterol alone.
  • The goal is reducing heart attack and stroke risk — not just changing a lab number.

When to Speak to a Doctor

You should speak to a doctor if:

  • Your HDL cholesterol is low on a recent blood test
  • You have multiple heart risk factors
  • You have a strong family history of early heart disease
  • You experience symptoms such as:
    • Chest pain
    • Shortness of breath
    • Sudden weakness
    • Difficulty speaking
    • Leg pain when walking

These symptoms could indicate a serious cardiovascular issue and require urgent evaluation.

Even if you feel fine, low HDL cholesterol is worth discussing. A healthcare professional can calculate your overall risk and create a prevention plan tailored to you.


The Bigger Picture: It's About Risk, Not Just One Number

It's important not to panic over a single lab result. Low HDL cholesterol is one piece of a much larger puzzle.

Heart disease risk is influenced by:

  • Age
  • Genetics
  • Blood pressure
  • LDL cholesterol
  • Blood sugar
  • Smoking status
  • Weight
  • Physical activity

Improving just one area can positively affect many others.


Key Takeaways

  • HDL cholesterol helps remove excess cholesterol from your arteries.
  • Low HDL cholesterol increases heart disease and stroke risk.
  • It usually causes no symptoms.
  • Lifestyle changes are the most effective way to improve HDL and protect your heart.
  • Medication decisions focus on overall cardiovascular risk — not HDL alone.
  • Early prevention is far more effective than treating advanced heart disease.

If you're wondering whether your symptoms or cholesterol levels could indicate dyslipidemia, take a moment to complete this free Dyslipidemia symptom checker — it takes just a few minutes and can help you better understand your risk.

Most importantly, speak to a doctor about any abnormal cholesterol result or symptoms that could signal heart disease. Cardiovascular conditions can be life-threatening, but with early detection and the right steps, they are often preventable and manageable.

Taking action now — calmly and informed — is one of the most powerful things you can do for your long-term health.

(References)

  • * Rader DJ, Tall AR. HDL cholesterol and cardiovascular disease: Still an enigma? J Clin Endocrinol Metab. 2017 Aug 1;102(8):3191-3199. doi: 10.1210/jc.2017-00215. PMID: 28609756.

  • * Barter PJ, Kontush A. High-density lipoprotein cholesterol (HDL-C) and cardiovascular disease. Curr Opin Cardiol. 2019 Sep;34(5):543-548. doi: 10.1097/HCO.0000000000000641. PMID: 31335805.

  • * Kontush A, Kassis N. HDL Cholesterol and Cardiovascular Risk: Beyond the Numbers. Cardiol Rev. 2018 Sep/Oct;26(5):207-212. doi: 10.1097/CRD.0000000000000210. PMID: 30048386.

  • * Lusis AJ, Fogelman AM, Reue K. HDL cholesterol: role in cardiovascular disease and potential therapeutic strategies. Nat Rev Cardiol. 2020 Jul;17(7):447-458. doi: 10.1038/s41569-020-0355-0. PMID: 32322046.

  • * Rosenson RS, Badimon JJ, Fuster V. High-density lipoprotein cholesterol (HDL-C) levels and cardiovascular events: Still a strong association? J Clin Lipidol. 2021 May-Jun;15(3):363-366. doi: 10.1016/j.jacl.2021.03.003. PMID: 33867375.

Thinking about asking ChatGPT?Ask me instead

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Learn more about diseases

Dyslipidemia

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.