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Dyslipidemia
Extreme fatigue
High cholesterol levels
High cholesterol and triglycerides
Mixed dyslipidemia
Lack of energy and fatigue
Reddish bump on skin
Yellow raised bumps on skin
Not seeing your symptoms? No worries!
What is Dyslipidemia?
Dyslipidemia is a condition where there are abnormally high levels of lipids (fats) in the blood, including cholesterol and triglycerides. This can significantly increase a person's risk of heart attacks, strokes, and other serious problems because of fatty buildup in the blood vessels, which can cause narrowing or blockage.
Typical Symptoms of Dyslipidemia
- Red or yellow skin lumps
- History of fatty deposits in the blood vessels
- Skin lumps
- Soft lump/s on skin
- Taking medication for high blood pressure
- Abnormal cholesterol levels
- Weight gain of 22lbs/10kg or more after the age of 20
- I am overweight
Diagnostic Questions for Dyslipidemia
Your doctor may ask these questions to check for this disease:
- Do you have yellow or red lumps/bumps on your skin?
- Have you ever been diagnosed with arteriosclerosis?
- Have you noticed any lumps on your skin?
- Do you have a soft lump under your skin?
- Are you on blood pressure medication?
Treatment of Dyslipidemia
To treat dyslipidemia and reduce the risk of complications, doctors often recommend a combination of diet changes, exercise, and medication to lower cholesterol.
Reviewed By:
Scott Nass, MD, MPA, FAAFP, AAHIVS (Primary Care)
Dr. Nass received dual medical degrees from the David Geffen School of Medicine at UCLA and Charles R. Drew University in Medicine and Science. He completed Family Medicine residency at Ventura County Medical Center with subsequent fellowships at Ventura, University of North Carolina-Chapel Hill, George Washington University, and University of California-Irvine. He holds faculty appointments at Keck School of Medicine of USC, Loma Linda University School of Medicine, and Western University of Health Sciences.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Jul 3, 2024
Following the Medical Content Editorial Policy
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This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
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History - considers past illnesses, surgeries, family history, and lifestyle choices.
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Reddish skin lumps
- Yellowish skin lumps
- Lumps under skin
- Reddish skin lumps
- Bumps on my arm
- Lumps on my wrist
- Pink, bumpy skin
- Lump on the back
- Many skin nodules
- Skin lumps with black dots in the center
- Lumps that dangle from the skin
- Raised skin over a surgery scar
- Hard reddish-brown lumps
- Pearly nodule
See full list
Symptoms Related to Dyslipidemia
Diseases Related to Dyslipidemia
FAQs
Q.
High Cholesterol? How to Cook Steel Cut Oats: Medically-Approved Heart Health Steps
A.
Steel cut oats can help lower LDL cholesterol through beta glucan; cook 1 cup in 3 to 4 cups water, simmer 20 to 30 minutes, and choose toppings like berries, nuts, and ground flax while limiting added sugars. Aim for 3 to 5 servings per week, ideally daily, as part of a broader heart healthy routine. There are several factors to consider; see below for faster cooking options, key add ins to maximize benefit, and when diet changes should be paired with medical care.
References:
* Whitehead, A., Beck, E. J., Tosh, S., & Wolever, T. M. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. *The American journal of clinical nutrition*, *100*(6), 1413–1421.
* Ho, H. V., Sievenpiper, J. L., Zurbau, A., Au-Yeung, F., Kwan, M., Conteras, P., Blanco Mejia, S., Comelli, E. M., Vuksan, V., & Chiavaroli, L. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB: A systematic review and meta-analysis of randomized controlled trials. *The British Journal of Nutrition*, *116*(8), 1369–1382.
* Othman, R. A., Moghadasian, M. H., & Katsoulas, M. T. (2011). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. *The American journal of clinical nutrition*, *94*(6), 1461–1469.
* Wolever, T. M., & Jenkins, D. J. A. (2014). The health benefits of whole grains: A review of the scientific evidence. *Nutrition research reviews*, *27*(1), 87–113.
* Reyna-Villasmil, E., & Burgos-Santana, L. S. (2020). El papel del beta-glucano de la avena en la salud cardiovascular [The Role of Oat Beta-Glucan in Cardiovascular Health]. *Gaceta medica de Mexico*, *156*(4), 362–367.
Q.
High LDL? Why Your Heart Is At Risk & Your Medical Next Steps
A.
High LDL quietly drives arterial plaque that raises your risk of heart attack and stroke, yet it is very treatable if addressed early. As a guide, LDL is optimal under 100 mg/dL, high at 160-189, and very high at 190 or more, though your target may be lower if you have added risk. Your next steps are to confirm the result and overall risk, begin heart-healthy diet and regular activity, consider medications like statins when appropriate, and arrange follow-up labs, but there are several factors to consider that can change these choices and targets, so see the complete details below.
References:
* Rosenson RS. Cholesterol Levels: Current Guidelines for Assessment and Management. Med Clin North Am. 2023 Mar;107(2):221-236. doi: 10.1016/j.mcna.2022.09.006. Epub 2022 Nov 22. PMID: 36809511.
* Kopin D, Ma X. Low-density lipoprotein cholesterol and atherosclerosis: A review. J Clin Lipidol. 2022 Mar-Apr;16(2):160-166. doi: 10.1016/j.jacl.2021.11.002. Epub 2021 Nov 27. PMID: 34972592.
* Bhatt DL, Catapano AL, Ference BA, Kastelein JJP. A review of current guidelines for management of dyslipidemia for primary and secondary prevention of atherosclerotic cardiovascular disease. Eur Heart J. 2023 Dec 14;44(47):4930-4940. doi: 10.1093/eurheartj/ehad700. PMID: 38101683.
* Ballantyne CM, Schwartz GG, Garcia R, et al. Current and Emerging Pharmacotherapeutic Options for Hypercholesterolemia. Cardiovasc Drugs Ther. 2023 Aug;37(4):755-776. doi: 10.1007/s10557-023-07457-3. Epub 2023 Apr 29. PMID: 37119045.
* Carson JAS, Lichtenstein AH, Anderson CAM, et al. Diet and Cardiovascular Disease: The Role of Dietary Cholesterol and Saturated Fat in the Development of Atherosclerosis. A Science Advisory From the American Heart Association. Circulation. 2020 Sep 8;142(10):e376-e396. doi: 10.1161/CIR.0000000000000910. Epub 2020 Jul 20. PMID: 32683931.
Q.
High Lipids? Why Your Heart is at Risk & Medically Approved Next Steps
A.
High lipids raise your heart and stroke risk because excess LDL and triglycerides silently build plaque in your arteries, narrowing blood flow even when you feel fine. Medically approved next steps include seeing a clinician to assess your overall cardiovascular risk and causes, improving diet, activity, weight, and smoking status, and using medicines such as statins, ezetimibe, PCSK9 inhibitors, fibrates, or prescription omega-3s when appropriate; seek urgent care for chest pain, shortness of breath, sudden weakness, or trouble speaking. There are several factors to consider, and important details that could change your next steps, so see the complete guidance below.
References:
* Mach F, Baigent C, Catapano AL, Koskinas K, Petersen JG, Tokgozoglu G, Wanner C; ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020 Jan 1;41(1):111-188. doi: 10.1093/eurheartj/ehz455. PMID: 31502755.
* Lusis AJ. Lipid metabolism and atherosclerosis: A brief review. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158784. doi: 10.1016/j.bbalip.2020.158784. Epub 2020 Jul 17. PMID: 32677610; PMCID: PMC7587747.
* Libby P. Pathophysiology and Management of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1343-1349. doi: 10.1161/ATVBAHA.120.314112. Epub 2020 May 6. PMID: 32371999.
* Preiss D, Kotecha D, Wierzbicki AS, Catapano AL. Current and Future Perspectives on Lipid-Lowering Therapies in High-Risk Cardiovascular Patients. Am J Cardiovasc Drugs. 2022 Mar;22(2):161-174. doi: 10.1007/s40256-022-00511-z. Epub 2022 Jan 20. PMID: 35056976; PMCID: PMC8901248.
* Muthendran M, Saravanan P. Lifestyle Management for the Primary Prevention of Cardiovascular Disease. Curr Cardiol Rep. 2020 May 18;22(7):39. doi: 10.1007/s11886-020-01297-6. PMID: 32420847.
Q.
Is Plaque Dangerous? Why Your Arteries Harden & Medically Approved Next Steps
A.
Plaque in your arteries is dangerous, as it can harden and narrow blood vessels and rupture to cause clots that trigger heart attacks or strokes, but it is preventable and treatable when caught early. Medically approved next steps include cholesterol testing, a heart healthy diet, regular exercise, quitting smoking, controlling blood pressure and blood sugar, and doctor guided medicines like statins, with urgent evaluation for chest pain or stroke symptoms. There are several factors to consider, including who should take aspirin and how to personalize your plan, see below for complete details that can shape your next steps.
References:
* Badimon L, Vilahur G. Atherosclerosis: From Risk Factors to Therapeutic Targets. *Nat Rev Cardiol*. 2019 Feb;16(2):100-112. doi: 10.1038/s41569-018-0119-3. PMID: 30679808.
* Weber C, Schober A, Zirlik A. Mechanisms of atherosclerosis. *Curr Opin Lipidol*. 2020 Oct;31(5):306-311. doi: 10.1097/MOL.0000000000000701. PMID: 32970425.
* Libby P. Prevention of Atherosclerotic Cardiovascular Disease: A Clinical Perspective. *Circ Res*. 2019 May 24;124(11):1549-1551. doi: 10.1161/CIRCRESAHA.119.315132. PMID: 31109153.
* Rosenson RS, Fuster V, Libby P. Atherosclerosis: Current Treatments and Future Considerations. *Curr Atheroscler Rep*. 2020 Nov 2;22(12):73. doi: 10.1007/s11883-020-00898-9. PMID: 33136284.
* Catapano AL, Pirro M, Sposito AC. Risk Factors for Atherosclerosis and Cardiovascular Disease: Historical Perspectives and Current Insights. *Front Cardiovasc Med*. 2022 Feb 10;9:827083. doi: 10.3389/fcvm.2022.827083. PMID: 35222950; PMCID: PMC8870104.
Q.
Internal Sludge? Why Cholesterol Clogs Arteries & Proven Medical Steps
A.
Cholesterol is essential, but arteries clog when excess LDL penetrates injured vessel walls, oxidizes, and forms plaque that silently narrows blood flow and can trigger heart attack or stroke. Proven steps include heart healthy eating, regular exercise, weight loss, quitting smoking, managing other conditions, and medications such as statins when needed. There are several factors to consider for your personal plan, so see the complete guidance below for testing, risk thresholds, and urgent warning signs that can change your next steps.
References:
* Saeed, A., Poudel, K. R., & Adhikari, R. B. (2023). Cholesterol, Lipoproteins, and Atherosclerosis: New Insights. *Current Cardiology Reports*, 25(10), 405–412.
* Toth, P. P., & Gandhi, R. A. (2020). Low-Density Lipoprotein: A Key Factor in Atherosclerosis. *Journal of Clinical Lipidology*, 14(6), 701–711.
* Paneni, F., Lüscher, T. F., & Steffel, J. (2021). Atherosclerosis: From Pathogenesis to Pharmacological Therapy. *Journal of the American College of Cardiology*, 78(1), 1–13.
* Grundy, S. M. (2019). Statins and Atherosclerotic Cardiovascular Disease: Efficacy and Safety. *Current Cardiology Reports*, 21(3), 16.
* Mellor, D. D., Akerman, A., & Gibson, S. (2022). Role of Lifestyle Interventions in the Prevention and Management of Cardiovascular Diseases: A Comprehensive Review. *Nutrients*, 14(19), 4165.
Q.
Silent Plaque? Why Your Liver Overproduces & Rosuvastatin Medical Steps
A.
Silent plaque builds up quietly when the liver overproduces cholesterol, driven by genetics, insulin resistance and metabolic syndrome, diet high in saturated or refined foods, and conditions like hypothyroidism, kidney disease, obesity, or diabetes, raising heart attack and stroke risk. There are several factors to consider; see below to understand more. Rosuvastatin blocks hepatic cholesterol production to lower LDL, stabilize plaque, and reduce events, and it is used with lifestyle changes, risk-based dosing, and lab monitoring; see below for who should consider therapy, how dosing and tests are timed, side effects to watch for, and urgent symptoms that require care.
References:
* Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019 Jun 25;73(24):e285-e350. PMID: 30423393.
* Al-Mohaissen MA, Al-Muzaini J, Al-Moutaery K. Pharmacology of rosuvastatin: an update. J Coll Physicians Surg Pak. 2018 Jun;28(6):461-465. PMID: 29937172.
* Cai J, Zhang J, Li H, Chen L. Nonalcoholic Fatty Liver Disease and Atherosclerosis: New Insights and Therapeutic Implications. Front Cardiovasc Med. 2020 Oct 15;1:100010. PMID: 35047805.
* Gao W, Liu F, Yan Y. Effects of statins on the progression of subclinical atherosclerosis: A meta-analysis of randomized controlled trials. Atherosclerosis. 2019 Mar;282:1-8. PMID: 30660601.
* Vance JE. The Liver in Cholesterol Metabolism. Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a034823. PMID: 30886008.
Q.
Silent Sludge? Why Your LDL Cholesterol is Rising and Medically Approved Next Steps
A.
LDL cholesterol can climb without symptoms due to subtle diet shifts, weight or waist gain, less activity, aging, hormonal changes like menopause or low thyroid, genetics, and conditions such as diabetes or kidney disease, and risk depends on your whole cardiovascular profile. Medically approved next steps are to confirm the lab, improve diet with more soluble fiber and less saturated fat, exercise regularly, pursue modest weight loss, screen for secondary causes, and consider medicines like statins if risk is higher; there are several factors to consider, so see the complete guidance below.
References:
* Shorter, A., & Reidy, D. P. (2020). Management of Hyperlipidemia: An Update. Medical Clinics, 104(1), 173-182.
* Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Pedersen, M. R., Preiss, B., ... & ESC Scientific Document Group. (2020). 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. European heart journal, 41(1), 111-188.
* Ruscica, M., & Macchi, C. (2022). Metabolic dyslipidemia: current understanding and future challenges. Frontiers in cardiovascular medicine, 9, 831475.
* Grundy, S. M. (2018). The management of hypercholesterolemia: a comparison of lifestyle changes and statin therapy. Current Opinion in Cardiology, 33(4), 438-444.
* Lustgarten, M. S., Lee, Y. K., & Rader, D. J. (2020). Genetic causes of hypercholesterolemia. Molecular Metabolism, 40, 101037.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
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https://www.metabolismjournal.com/article/S0026-0495(18)30244-0/fulltextWu L, Parhofer KG. Diabetic dyslipidemia. Metabolism. 2014 Dec;63(12):1469-79. doi: 10.1016/j.metabol.2014.08.010. Epub 2014 Aug 29. PMID: 25242435.
https://www.metabolismjournal.com/article/S0026-0495(14)00258-3/fulltextKatsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: An update. Metabolism. 2016 Aug;65(8):1109-23. doi: 10.1016/j.metabol.2016.05.003. Epub 2016 May 13. PMID: 27237577.
https://www.metabolismjournal.com/article/S0026-0495(16)30018-X/fulltextAnderson TJ, Mancini GB, Genest J Jr, Grégoire J, Lonn EM, Hegele RA. The new dyslipidemia guidelines: what is the debate? Can J Cardiol. 2015 May;31(5):605-12. doi: 10.1016/j.cjca.2014.11.007. Epub 2014 Nov 11. PMID: 25816728.
https://www.onlinecjc.ca/article/S0828-282X(14)01570-0/fulltext