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Published on: 2/28/2026
High cholesterol, especially high LDL, silently causes plaque buildup that damages arteries and increases the risk of heart attack, stroke, and peripheral artery disease, so regular screening is crucial.
There are several factors to consider and next steps can vary; core treatments include a heart healthy diet, exercise, weight loss, quitting smoking, and medications such as statins, ezetimibe, or PCSK9 inhibitors when needed. See the complete guidance below for target numbers, who needs earlier testing, when to seek urgent care, and how to choose the right plan with your doctor.
High cholesterol levels are one of the most common — and most misunderstood — health concerns today. Millions of adults have elevated cholesterol and don't even know it. The reason? High cholesterol usually causes no symptoms until serious damage has already occurred.
Understanding what cholesterol is, how it affects your heart, and what you can do about it can significantly reduce your risk of heart attack, stroke, and other cardiovascular problems.
Let's break it down clearly and practically.
Cholesterol is a waxy, fat-like substance found in your blood. Your body needs it to build cells and make hormones. But too much cholesterol in your bloodstream can become dangerous.
When your doctor checks your cholesterol levels, they typically measure:
LDL cholesterol can stick to the walls of your arteries, forming plaque. Over time, plaque builds up and narrows the arteries — a condition called atherosclerosis.
This narrowing:
HDL, on the other hand, helps remove excess cholesterol from your bloodstream.
Your heart relies on open, flexible arteries to deliver oxygen-rich blood. When cholesterol levels are high, plaque slowly accumulates inside artery walls.
Here's what can happen:
Plaque buildup in the arteries supplying the heart can cause:
If plaque blocks blood flow to the brain — or a clot forms — it can lead to a stroke.
Reduced blood flow to the legs can cause:
The key point: High cholesterol levels damage blood vessels silently for years before symptoms appear.
General adult targets (your doctor may individualize these):
If you have diabetes, high blood pressure, or a history of heart disease, your target LDL may be significantly lower.
Anyone can develop high cholesterol, but certain factors increase risk:
If high cholesterol runs in your family, you may want to use a free, AI-powered Dyslipidemia symptom checker to assess your risk and learn what symptoms or factors may apply to your situation.
High cholesterol levels usually have no warning signs.
You will not feel plaque forming in your arteries. Many people only discover they have high cholesterol after:
This is why routine screening is so important.
Most adults should have their cholesterol checked:
The good news: High cholesterol is treatable and manageable.
Treatment usually includes lifestyle changes and sometimes medication.
Small, consistent changes can make a significant impact.
Focus on:
Reduce:
A heart-healthy eating pattern such as the Mediterranean-style diet has strong scientific backing for lowering cholesterol levels.
Exercise helps:
Aim for:
Even 30 minutes a day, five days a week, can improve cholesterol levels.
Losing even 5–10% of your body weight can:
Weight loss doesn't have to be extreme to be meaningful.
Smoking:
Quitting improves heart health almost immediately and significantly reduces long-term risk.
If lifestyle changes are not enough, your doctor may prescribe medication.
Common options include:
Statins are among the most studied medications in medicine and have been shown to significantly reduce heart attacks and strokes in high-risk individuals.
Medication decisions are based on:
Plaque buildup can sometimes stabilize or partially regress with:
The earlier high cholesterol levels are addressed, the better the outcome.
You should speak to a doctor if you:
If you ever experience symptoms such as:
Seek emergency medical care immediately.
High cholesterol is manageable — but heart attacks and strokes can be life-threatening. It is always safer to be evaluated.
High cholesterol levels increase your risk of heart disease because they silently damage your arteries over time. The process is gradual but serious.
The good news:
You do not need to panic — but you do need to act.
If you're unsure about your risk, consider using a free Dyslipidemia symptom checker to get personalized insights before your next doctor's visit.
Most importantly, speak to a doctor about your cholesterol levels, especially if you have risk factors or a family history of heart disease. Addressing high cholesterol today can help protect your heart for decades to come.
(References)
* Packard CJ, Libby P. Dyslipidemia and Atherosclerosis: New Insights into Pathophysiology and Therapeutic Targets. Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):250-264. PMID: 35058204.
* Wang Z, Zhang J, Li Y, Meng L, Wang F. High Blood Cholesterol and Cardiovascular Disease: The Role of Diet, Lifestyle, and Medications. J Cardiovasc Transl Res. 2021 Oct;14(5):856-869. PMID: 34168270.
* Mach F, Baigent C, Catapano AL, Koskinas KC, Richter E, Ryden L, et al. 2021 ESC/EAS Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk. Eur Heart J. 2021 Sep 21;42(37):3232-3331. PMID: 34499026.
* Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Smith GD, Ebrahim S. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018 May 17;5(5):CD004816. PMID: 29775086.
* Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Deswal A, Goldman L, et al. 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction With Nonstatin Therapies: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Heart Assoc. 2021 Jul 6;10(13):e020583. PMID: 34176766.
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