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Published on: 1/29/2026

What happens during a bowel flare-up?

During a bowel flare-up in IBD, the immune system overreacts and inflames the intestinal lining, causing swelling and sometimes ulcers that disrupt absorption and motility. This leads to urgent diarrhea, cramping or pain, and often blood or mucus in the stool. Whole-body effects like fatigue, low appetite, fever, and weight loss can appear, and severity ranges from mild to serious with risks like dehydration or ongoing bleeding. There are several factors to consider, including triggers, red flags, and treatments that can change your next steps; see below to understand more.

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Explanation

What Happens During a Bowel Flare-Up?

A bowel flare-up is a period when digestive symptoms suddenly worsen after a time of relative calm. For people living with IBD (Inflammatory Bowel Disease)—which includes Crohn's disease and ulcerative colitis—flare-ups are a core part of the condition. They reflect a temporary increase in inflammation inside the digestive tract, which can disrupt how the bowel works and how a person feels day to day.

Understanding what happens during a bowel flare-up can help you recognize symptoms early, manage them more effectively, and know when it's important to seek medical care.


What Is a Bowel Flare-Up?

A bowel flare-up occurs when the immune system becomes more active than it should be and attacks the lining of the digestive tract. In IBD, this immune response causes ongoing inflammation, not just irritation.

During a flare-up:

  • Inflammation increases in the bowel wall
  • The lining of the intestine may become swollen or damaged
  • The bowel struggles to absorb water and nutrients properly
  • Normal digestion and bowel movements are disrupted

Flare-ups can last days, weeks, or longer, depending on the severity and how quickly treatment is started.


What Triggers an IBD Flare-Up?

Not all flare-ups have a clear cause, but common triggers include:

  • Stopping or missing IBD medications
  • Infections, such as stomach viruses or food poisoning
  • High stress or emotional strain
  • Certain medications, especially NSAIDs like ibuprofen
  • Dietary changes, particularly foods that are hard to digest
  • Smoking, especially in Crohn's disease

It's important to note that flare-ups are not caused by stress alone or by something a person "did wrong." IBD is a medical condition involving the immune system.


What Symptoms Occur During a Bowel Flare-Up?

Symptoms vary depending on whether someone has Crohn's disease or ulcerative colitis, and which part of the bowel is affected. However, many people with IBD experience similar patterns during a flare.

Common Digestive Symptoms

  • Diarrhea, sometimes urgent or frequent
  • Abdominal pain or cramping, often worsening after meals
  • Blood or mucus in the stool, especially in ulcerative colitis
  • Increased gas or bloating
  • A feeling of incomplete bowel emptying

These symptoms happen because inflammation interferes with normal bowel movement and fluid absorption.


Whole-Body (Systemic) Symptoms

IBD is not limited to the gut. During a flare-up, inflammation can affect the entire body, leading to:

  • Fatigue or low energy
  • Loss of appetite
  • Unintended weight loss
  • Low-grade fever
  • General feeling of being unwell

These symptoms are real physical effects of inflammation—not weakness or lack of effort.


What's Happening Inside the Bowel?

During an IBD flare-up, several physical changes occur in the digestive tract:

  • Inflamed tissue becomes swollen, narrowing the intestinal space
  • Ulcers or sores may form in the bowel lining
  • Increased fluid secretion leads to diarrhea
  • Nerve sensitivity increases, making pain more noticeable
  • Healing slows, especially if inflammation is ongoing

Over time, repeated flare-ups can lead to complications such as scarring, narrowing of the bowel, or anemia from chronic blood loss. This is why managing inflammation early is so important.


How Is an IBD Flare-Up Different From IBS?

IBD is often confused with Irritable Bowel Syndrome (IBS), but they are very different conditions.

Key differences include:

  • IBD causes visible inflammation and tissue damage
  • IBS does not cause inflammation or permanent bowel damage
  • IBD can be life-threatening if untreated
  • IBS is a functional disorder, not an inflammatory disease

That said, symptoms can overlap. If you're unsure what's causing your bowel symptoms, using a free AI-powered tool to check for Irritable Bowel Syndrome (IBS) can help you understand whether your symptoms align more closely with IBS or something that requires urgent medical attention.


How Severe Can a Bowel Flare-Up Be?

Flare-ups range from mild to severe.

Mild Flare-Ups May Include:

  • Slight increase in bowel movements
  • Mild abdominal discomfort
  • Manageable fatigue

Moderate to Severe Flare-Ups May Include:

  • Persistent diarrhea (including at night)
  • Significant abdominal pain
  • Ongoing bleeding
  • Dehydration
  • Rapid weight loss

Severe flare-ups can require hospitalization, especially if there is risk of dehydration, infection, or bowel complications.


How Are IBD Flare-Ups Treated?

Treatment depends on severity and location of inflammation. The goal is to reduce inflammation and restore remission.

Common approaches include:

  • Anti-inflammatory medications (such as aminosalicylates)
  • Steroids for short-term control of moderate to severe flares
  • Immunomodulators or biologic therapies to control immune response
  • Antibiotics, if infection is suspected
  • Nutritional support, especially during severe symptoms

Many people worry about medications, but untreated inflammation poses greater long-term risks than most therapies.


What You Can Do During a Flare-Up

While medical treatment is essential, supportive steps can help:

  • Stick to simple, easy-to-digest foods
  • Drink plenty of fluids to prevent dehydration
  • Rest when needed—fatigue is part of inflammation
  • Avoid foods that worsen symptoms
  • Take medications exactly as prescribed

Tracking symptoms can also help your healthcare provider adjust treatment effectively.


When Should You Speak to a Doctor?

You should speak to a doctor promptly if you experience:

  • Ongoing blood in stool
  • Severe or worsening abdominal pain
  • Fever with bowel symptoms
  • Signs of dehydration
  • Unexplained weight loss
  • Symptoms that interfere with daily life

Some IBD complications can be serious or life-threatening if ignored. Early care can prevent long-term damage and improve quality of life.


Final Thoughts

A bowel flare-up in IBD is more than a "bad stomach day." It reflects active inflammation that needs attention, understanding, and appropriate care. While flare-ups can feel unpredictable and frustrating, effective treatments exist, and many people with IBD live full, active lives with the right support.

If you're experiencing ongoing bowel symptoms and are unsure of the cause, tools like a symptom check for Irritable Bowel Syndrome (IBS) may help you organize your concerns—but always follow up and speak to a doctor about anything that could be serious or life-threatening. Early evaluation and treatment truly matter when it comes to bowel health.

(References)

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  • * Lichtenstein GR, Loftus EV Jr, Isaacs KL, Regueiro MD, Gerson LB, Siegmund B, Sweeney CP, Thayu M, Bressler B, Siegel CA. ACG Clinical Guideline: Management of Crohn's Disease in Adults. Am J Gastroenterol. 2021 Jul 1;116(7):1373-1402. doi: 10.14309/ajg.0000000000001272. PMID: 34103522.

  • * Ungaro R, Mehandru S, Allen PB, Colombel JF, Sands BE. Ulcerative colitis: an update. Nat Rev Dis Primers. 2023 Apr 20;9(1):21. doi: 10.1038/s41572-023-00438-x. PMID: 37081014.

  • * Enck P, Azpiroz F, Boeckxstaens G, Elsenbruch S, Fox M, Mayer EA, Schmulson MJ, Tack J. Functional gastrointestinal disorders. Nat Rev Dis Primers. 2022 Jul 28;8(1):50. doi: 10.1038/s41572-022-00384-y. PMID: 35903333.

  • * Ni J, Wu GD, Albenberg C, Tomov VT. Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):573-587. doi: 10.1038/nrgastro.2017.103. Epub 2017 Aug 25. PMID: 28840887.

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