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Published on: 1/29/2026
During a bowel flare-up in IBD, the immune system overreacts and inflames the intestinal lining, causing swelling and sometimes ulcers that disrupt absorption and motility. This leads to urgent diarrhea, cramping or pain, and often blood or mucus in the stool. Whole-body effects like fatigue, low appetite, fever, and weight loss can appear, and severity ranges from mild to serious with risks like dehydration or ongoing bleeding. There are several factors to consider, including triggers, red flags, and treatments that can change your next steps; see below to understand more.
A bowel flare-up is a period when digestive symptoms suddenly worsen after a time of relative calm. For people living with IBD (Inflammatory Bowel Disease)—which includes Crohn's disease and ulcerative colitis—flare-ups are a core part of the condition. They reflect a temporary increase in inflammation inside the digestive tract, which can disrupt how the bowel works and how a person feels day to day.
Understanding what happens during a bowel flare-up can help you recognize symptoms early, manage them more effectively, and know when it's important to seek medical care.
A bowel flare-up occurs when the immune system becomes more active than it should be and attacks the lining of the digestive tract. In IBD, this immune response causes ongoing inflammation, not just irritation.
During a flare-up:
Flare-ups can last days, weeks, or longer, depending on the severity and how quickly treatment is started.
Not all flare-ups have a clear cause, but common triggers include:
It's important to note that flare-ups are not caused by stress alone or by something a person "did wrong." IBD is a medical condition involving the immune system.
Symptoms vary depending on whether someone has Crohn's disease or ulcerative colitis, and which part of the bowel is affected. However, many people with IBD experience similar patterns during a flare.
These symptoms happen because inflammation interferes with normal bowel movement and fluid absorption.
IBD is not limited to the gut. During a flare-up, inflammation can affect the entire body, leading to:
These symptoms are real physical effects of inflammation—not weakness or lack of effort.
During an IBD flare-up, several physical changes occur in the digestive tract:
Over time, repeated flare-ups can lead to complications such as scarring, narrowing of the bowel, or anemia from chronic blood loss. This is why managing inflammation early is so important.
IBD is often confused with Irritable Bowel Syndrome (IBS), but they are very different conditions.
Key differences include:
That said, symptoms can overlap. If you're unsure what's causing your bowel symptoms, using a free AI-powered tool to check for Irritable Bowel Syndrome (IBS) can help you understand whether your symptoms align more closely with IBS or something that requires urgent medical attention.
Flare-ups range from mild to severe.
Severe flare-ups can require hospitalization, especially if there is risk of dehydration, infection, or bowel complications.
Treatment depends on severity and location of inflammation. The goal is to reduce inflammation and restore remission.
Common approaches include:
Many people worry about medications, but untreated inflammation poses greater long-term risks than most therapies.
While medical treatment is essential, supportive steps can help:
Tracking symptoms can also help your healthcare provider adjust treatment effectively.
You should speak to a doctor promptly if you experience:
Some IBD complications can be serious or life-threatening if ignored. Early care can prevent long-term damage and improve quality of life.
A bowel flare-up in IBD is more than a "bad stomach day." It reflects active inflammation that needs attention, understanding, and appropriate care. While flare-ups can feel unpredictable and frustrating, effective treatments exist, and many people with IBD live full, active lives with the right support.
If you're experiencing ongoing bowel symptoms and are unsure of the cause, tools like a symptom check for Irritable Bowel Syndrome (IBS) may help you organize your concerns—but always follow up and speak to a doctor about anything that could be serious or life-threatening. Early evaluation and treatment truly matter when it comes to bowel health.
(References)
* Neurath MF. The gut as a therapeutic target in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):395-408. doi: 10.1038/nrgastro.2017.58. Epub 2017 May 17. PMID: 28512391.
* Lichtenstein GR, Loftus EV Jr, Isaacs KL, Regueiro MD, Gerson LB, Siegmund B, Sweeney CP, Thayu M, Bressler B, Siegel CA. ACG Clinical Guideline: Management of Crohn's Disease in Adults. Am J Gastroenterol. 2021 Jul 1;116(7):1373-1402. doi: 10.14309/ajg.0000000000001272. PMID: 34103522.
* Ungaro R, Mehandru S, Allen PB, Colombel JF, Sands BE. Ulcerative colitis: an update. Nat Rev Dis Primers. 2023 Apr 20;9(1):21. doi: 10.1038/s41572-023-00438-x. PMID: 37081014.
* Enck P, Azpiroz F, Boeckxstaens G, Elsenbruch S, Fox M, Mayer EA, Schmulson MJ, Tack J. Functional gastrointestinal disorders. Nat Rev Dis Primers. 2022 Jul 28;8(1):50. doi: 10.1038/s41572-022-00384-y. PMID: 35903333.
* Ni J, Wu GD, Albenberg C, Tomov VT. Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):573-587. doi: 10.1038/nrgastro.2017.103. Epub 2017 Aug 25. PMID: 28840887.
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