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Published on: 1/30/2026

Can inflammatory bowel disease cause weight gain?

Yes, inflammatory bowel disease can cause weight gain, often indirectly due to corticosteroid treatment, weight rebound during remission, reduced physical activity, dietary shifts toward easier-to-digest but calorie-dense foods, and short-term fluid retention. There are several factors to consider. See below for signs that warrant medical attention and practical next steps, including medication review to limit steroids, dietitian-guided nutrition, gradual activity, and how IBS differs from IBD to help guide your care.

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Explanation

Can Inflammatory Bowel Disease (IBD) Cause Weight Gain?

Inflammatory Bowel Disease (IBD) is best known for symptoms like abdominal pain, diarrhea, fatigue, and weight loss. However, many people are surprised to notice weight gain at certain points in their IBD journey. So, can IBD cause weight gain? The short answer is yes, it can—but not always for the reasons people expect.

This article explains how and why weight gain can occur in IBD, when it may be a concern, and what to do about it—using clear, common language and relying on well-established medical knowledge.


Understanding IBD in Simple Terms

IBD is a group of chronic conditions that cause inflammation in the digestive tract. The two main types are:

  • Crohn's disease, which can affect any part of the digestive tract
  • Ulcerative colitis, which affects the colon and rectum

IBD is an immune-mediated disease, meaning the immune system mistakenly attacks the gut. Symptoms often come and go in cycles of flares (active inflammation) and remission (few or no symptoms).

Because inflammation increases energy needs and reduces nutrient absorption, unintentional weight loss is common—especially during flares. But weight gain can and does happen.


How IBD Can Lead to Weight Gain

Weight gain in IBD is usually indirect, meaning it happens because of treatment, lifestyle changes, or recovery from inflammation rather than from the disease itself.

1. Steroid Medications Are a Major Factor

One of the most common reasons for weight gain in IBD is the use of corticosteroids, such as prednisone. These drugs are effective at calming inflammation but have well-known side effects.

Steroids can cause:

  • Increased appetite
  • Fat redistribution (especially in the face, neck, and abdomen)
  • Fluid retention
  • Changes in blood sugar

Even short-term steroid use can lead to noticeable weight gain. This type of weight gain is common, temporary, and medication-related, not a personal failure or lack of control.


2. Weight "Rebound" After a Flare

After a long flare, the body often tries to restore lost weight once inflammation is controlled. This is sometimes called rebound weight gain.

During remission:

  • Appetite improves
  • Digestion becomes more efficient
  • Nutrient absorption increases
  • Energy levels rise, leading to more regular eating

In this context, some weight gain can be a sign of healing, especially if a person was underweight before.


3. Reduced Physical Activity

Fatigue, joint pain, anemia, and fear of triggering symptoms can reduce physical activity in people with IBD.

Less movement over time can:

  • Lower daily calorie use
  • Reduce muscle mass
  • Contribute to gradual weight gain

This is especially true during long periods of remission when calorie intake stays high but activity remains low.


4. Dietary Changes Made to "Protect the Gut"

Many people with IBD avoid high-fiber or trigger foods and rely on more refined, calorie-dense options that are easier to digest.

Examples include:

  • White bread and pasta
  • Rice
  • Potatoes
  • Processed or packaged "safe foods"

These foods can be helpful during flares, but over time they may contribute to unintentional weight gain, especially if balanced nutrition is not revisited during remission.


5. Fluid Retention and Inflammation

IBD-related inflammation and certain medications can cause the body to hold onto fluid, leading to short-term weight increases.

This type of weight gain:

  • Can happen quickly
  • Is not fat gain
  • Often improves when inflammation or medication changes

6. Surgery and Changes in Metabolism

Some people with IBD undergo bowel surgery. After recovery:

  • Nutrient absorption may improve
  • Appetite may increase
  • The body may store energy more efficiently

For some, this results in healthy weight restoration. For others, it may tip into overweight if eating habits are not adjusted over time.


Is Weight Gain in IBD a Problem?

Weight gain is not automatically bad, especially if it represents recovery from malnutrition. However, excess weight can increase the risk of:

  • Heart disease
  • Type 2 diabetes
  • Joint pain
  • Fatty liver disease

Emerging research also suggests that obesity may worsen inflammation in IBD or make treatment less effective for some people. That said, this area is still being actively studied.

The key issue is not the number on the scale, but whether weight changes are:

  • Sudden or unexplained
  • Accompanied by swelling, shortness of breath, or severe fatigue
  • Linked to medication side effects

IBD vs. IBS: Why the Difference Matters

IBD is often confused with Irritable Bowel Syndrome (IBS). While the symptoms can overlap, they are very different conditions.

  • IBD involves visible inflammation and can be serious
  • IBS does not cause inflammation or intestinal damage

If you're unsure whether your digestive symptoms like bloating, cramping, or changes in bowel habits might be related to Irritable Bowel Syndrome (IBS) rather than IBD, you can use a free AI-powered symptom checker to better understand what you're experiencing and determine if a doctor's visit is needed.


When to Talk to a Doctor

You should speak to a doctor if weight gain with IBD is:

  • Rapid or unexplained
  • Occurring with swelling in the legs, face, or abdomen
  • Happening alongside shortness of breath or chest pain
  • Causing emotional distress or affecting daily life

These could point to medication side effects, hormonal issues, or other health concerns that need medical attention. Anything that could be life-threatening or serious should always be evaluated by a healthcare professional.


Practical, Balanced Steps to Manage Weight with IBD

Managing weight with IBD is about supporting health, not restriction.

Helpful steps may include:

  • Reviewing medications with your doctor to minimize steroid use when possible
  • Working with a dietitian familiar with IBD
  • Gradually increasing physical activity during remission
  • Focusing on nutrient-dense foods rather than "safe but empty" calories
  • Monitoring trends over time instead of day-to-day weight changes

The Bottom Line

Yes, IBD can cause weight gain, but usually indirectly—through medications, recovery from flares, reduced activity, or dietary adjustments. Weight gain is not a personal failure and does not mean your disease is out of control.

What matters most is understanding why the weight change is happening and whether it supports or harms your overall health. With the right medical guidance, most people with IBD can find a balance that supports both disease control and long-term well-being.

If you have concerns, don't guess—speak to a doctor. Getting clear answers is one of the most important steps in managing IBD safely and confidently.

(References)

  • * Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. Obesity and inflammatory bowel disease: a complex relationship. Therap Adv Gastroenterol. 2018;11:1756284818804928. Published 2018 Oct 18. doi:10.1177/1756284818804928

  • * Zatorski P, Wark J, Ananthakrishnan AN. Weight trajectory in inflammatory bowel disease: a population-based study. Clin Gastroenterol Hepatol. 2021;19(11):2315-2321.e2. doi:10.1016/j.cgh.2020.10.043

  • * Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. Weight gain and obesity in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2018;47(5):547-558. doi:10.1111/apt.14500

  • * Li X, Yu Y, Liu X, et al. Risk of obesity in inflammatory bowel disease: a systematic review and meta-analysis. BMC Gastroenterol. 2019;19(1):151. Published 2019 Aug 7. doi:10.1186/s12876-019-1065-5

  • * Fardet L, Kassar A, Nahon S, et al. Weight gain associated with glucocorticoids for inflammatory bowel diseases in older adults. Dig Dis Sci. 2020;65(3):792-799. doi:10.1007/s10620-019-05809-9

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