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Published on: 2/19/2026
Sepsis is a life-threatening internal fire where an infection triggers an out-of-control immune response that leads to widespread inflammation, leaky blood vessels, dangerously low blood pressure, organ failure, and death if not treated quickly, yet early care can be lifesaving. Watch for infection plus fever or very low temperature, rapid heart or breathing, severe pain, clammy skin, confusion, bluish or pale skin, or low urine and seek emergency care; hospital treatment includes urgent antibiotics, IV fluids, oxygen, blood pressure support, and removing the infection source, while prevention centers on early infection care, completing antibiotics, wound care, hand hygiene, and vaccines. There are several factors to consider that can affect your next steps; see below for complete details.
When people describe sepsis, they often call it an "internal fire." That's not far from the truth. Sepsis happens when your body's response to an infection becomes extreme and harmful. Instead of fighting off germs in a controlled way, the immune system goes into overdrive. The result? Widespread inflammation that can damage tissues, disrupt blood flow, and cause organs to fail.
Sepsis is a medical emergency. But it's also treatable—especially when caught early. Understanding what it is, why it happens, and what to look for can make a lifesaving difference.
Sepsis is a life-threatening condition that occurs when the body's response to an infection injures its own tissues and organs.
It can begin with almost any infection, including:
Most infections stay localized and resolve with proper treatment. But sometimes, the immune system releases chemicals into the bloodstream that trigger widespread inflammation. Blood vessels may leak. Blood pressure can drop. Oxygen and nutrients struggle to reach vital organs.
If not treated quickly, sepsis can progress to:
This is why early recognition is so important.
Think of your immune system as a fire department. Normally, it puts out small fires (infections) efficiently. But in sepsis, the response becomes chaotic—like spraying water everywhere, damaging the building in the process.
Here's what happens inside the body:
When organs don't receive enough oxygen-rich blood, they begin to fail. That's the "shutdown" people refer to.
Anyone can develop sepsis. However, certain groups are at higher risk:
Even healthy people can develop sepsis, especially after a severe infection or injury.
Sepsis symptoms can develop quickly and may initially look like flu or worsening infection.
Common early signs include:
As sepsis worsens, symptoms may include:
If you notice these symptoms, especially alongside an infection, seek medical care immediately.
If you're experiencing concerning symptoms and want to understand whether they could indicate sepsis, Ubie's free AI-powered Sepsis Symptom Checker can help assess your risk in minutes—so you can make an informed decision about seeking immediate care.
Doctors diagnose sepsis based on:
There is no single "sepsis test." It's a clinical diagnosis based on signs of infection combined with signs of organ dysfunction.
Because sepsis can progress rapidly, doctors often begin treatment before every test result is available.
Sepsis is treated in a hospital, often in an intensive care unit (ICU). Treatment usually includes:
The earlier treatment begins, the better the outcome.
Not all cases are preventable, but you can reduce your risk.
If you have an infection that suddenly worsens, don't ignore it.
Many people recover fully, especially with early treatment. However, some experience what's known as post-sepsis syndrome, which may include:
Recovery can take weeks to months. Follow-up care is important. Physical therapy, mental health support, and ongoing medical supervision may help.
Sepsis can move fast. What starts as a manageable infection can escalate within hours.
However:
Sepsis is serious—but it is treatable.
The key difference between recovery and severe complications often comes down to time.
Call emergency services or go to the nearest emergency department if you or someone else has:
Do not wait to "see if it gets better."
Sepsis is not rare. But it is also not inevitable. Most infections do not turn into sepsis.
The goal is awareness—not panic.
If something feels wrong, especially during an infection, listen to your body. Take action quickly by using Ubie's free AI-powered Sepsis Symptom Checker to evaluate your symptoms and get guidance on your next steps. And most importantly, speak to a doctor immediately about anything that could be life threatening or serious.
Prompt medical care saves lives.
Sepsis is an internal fire—but with early recognition and proper treatment, it can be extinguished.
(References)
* Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll K, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. PMID: 26903338.
* Chaudhry H, Duggal A, Rosenthal MD, Bander J, Brause P, Pinsky MR. Organ dysfunction in sepsis. Crit Care Med. 2023 Mar 1;51(3):e116-e126. doi: 10.1097/CCM.0000000000005700. Epub 2022 Nov 21. PMID: 36410499.
* Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Levy M, Machado FR, McCarthy M, McIntrye L, Ostermann C, Prescott HC, Schorr S, Simpson S, Sirounis D, Taylor B, Townsend S, van der Poll K, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-e1143. doi: 10.1097/CCM.0000000000005337. Epub 2021 Sep 30. PMID: 34509763.
* Hotchkiss RS, Moldawer LL, Opal SM, Coopersmith CM, Deutschman CS, Levy MM. Sepsis and septic shock. Nat Rev Dis Primers. 2023 May 11;9(1):20. doi: 10.1038/s41572-023-00431-7. PMID: 37169871.
* Pugin J, Contou D, de Prost N, Legrand M. Current and future treatments for sepsis: The dawn of host-directed therapy. Intensive Care Med. 2023 Apr;49(4):371-382. doi: 10.1007/s00134-023-07010-z. Epub 2023 Mar 2. PMID: 36862368.
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