Published on: 4/28/2025
Pain running along one side from the shoulder to the toe can be caused by conditions affecting the muscles or nerves, such as hypothyroid myopathy or other musculoskeletal problems. Treatment depends on finding the root cause, which may include medications, physical therapy, and lifestyle changes.
When pain spreads from your shoulder all the way down to your toe on one side, it could be a sign of a condition affecting your muscles or nerves. The most common causes are musculoskeletal issues like poor posture, muscle strain, or nerve compression, which might start in the back and travel down your leg. A less common cause is hypothyroid myopathy—a condition that occurs when the thyroid, a small gland in your neck, doesn’t make enough hormones. This may leave your muscles feeling weak and sore. Doctors typically start the work up by checking your overall health, looking at your thyroid levels, and examining your muscles and joints. Once they understand the cause of your pain, treatments can vary. For example, if it’s due to hypothyroidism, hormone replacement may help. For musculoskeletal issues, a plan might include physical therapy to strengthen and stretch your muscles, pain-relieving medications, and changes in your daily routine. Seeing a healthcare provider is important to determine the exact cause and to create a treatment plan that works best for you.
(References)
Fariduddin MM, Haq N, Bansal N. Hypothyroid Myopathy. [Updated 2024 Jun 7]. In: StatPearls [Internet].
Wahl EC, Smith D, Sesto M, Boissonnault W. Differential diagnosis of a patient with low back and toe pain. J Man Manip Ther. 2013 May;21(2):81-9. doi: 10.1179/2042618612Y.0000000023. PMID: 24421618; PMCID: PMC3649355.
El-Tallawy SN, Nalamasu R, Salem GI, LeQuang JAK, Pergolizzi JV, Christo PJ. Management of Musculoskeletal Pain: An Update with Emphasis on Chronic Musculoskeletal Pain. Pain Ther. 2021 Jun;10(1):181-209. doi: 10.1007/s40122-021-00235-2. Epub 2021 Feb 11. PMID: 33575952; PMCID: PMC8119532.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Purpose and positioning of servicesUbie Doctor’s Note is a service for informational purposes, and the provision of information by physicians, medical professionals, etc. is not a medical practice. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.