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Published on: 10/28/2025

Is a liver transplant the only option at stage 4 cirrhosis?

A liver transplant is a common treatment for stage 4 cirrhosis, but other options like auxiliary liver transplantation and potential therapies targeting HNF4α are being explored. See below to understand more.

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Explanation

Stage 4 cirrhosis is a severe liver condition, and a liver transplant is often considered a primary treatment. However, there are other potential options being researched.

  1. Auxiliary Liver Transplantation: This involves transplanting part of a donor liver to support the patient's liver function. Research is ongoing to improve this method and make it more effective.

  2. Therapies Targeting HNF4α: Scientists are exploring treatments that focus on HNF4α, a protein that could help improve liver function in end-stage liver disease. This is still in the research phase and not widely available yet.

While a full liver transplant remains a key treatment, these alternatives show promise for the future and may provide additional options for patients with stage 4 cirrhosis.

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