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Published on: 7/22/2025

Can Lyme disease be misdiagnosed as depression?

Lyme disease can sometimes be misdiagnosed as depression because they share similar symptoms, like fatigue and mood changes.

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Explanation

Lyme disease and depression can have overlapping symptoms, which might lead to misdiagnosis. According to the medical literature, Lyme disease can cause symptoms such as tiredness, mood changes, and cognitive difficulties, which can also be seen in depression.

Here are some points to consider:

  • Similar Symptoms: Both conditions can cause fatigue, difficulty concentrating, and mood changes, making them hard to tell apart.
  • Diagnosis Challenges: Proper testing and evaluation are important to distinguish between Lyme disease and depression.

If you or someone you know is experiencing mental health concerns, it is important to seek help from a healthcare provider or visit 988lifeline.org.

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