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Published on: 5/5/2026
Original Medicare does not cover platelet-rich plasma injections for knee osteoarthritis or chronic wounds because these treatments are still considered experimental. Some Medicare Advantage plans may offer limited PRP benefits, and coverage through clinical trials is possible under Coverage with Evidence Development.
See below for important details on costs, plan rules, clinical evidence, and next steps to determine if PRP is right for you.
Platelet-Rich Plasma (PRP) therapy uses a patient's own blood components to promote healing. It's gaining attention for conditions like knee osteoarthritis and chronic wounds. If you're a Medicare beneficiary interested in PRP for Medicare patients, here's what you need to know.
PRP is made by drawing a small amount of your blood, spinning it in a centrifuge, and concentrating the platelets. Platelets release growth factors that may:
Physicians inject PRP into the injured area—commonly knees for arthritis or skin ulcers for wound healing.
Medicare consists mainly of:
Most outpatient procedures and physician services fall under Part B. However, Medicare only covers treatments deemed "medically necessary" and supported by solid clinical evidence.
Medicare Advantage (Part C) plans are offered by private insurers approved by Medicare. They must cover all Part A and Part B services but may have different rules:
Medigap (supplemental) policies fill cost-sharing gaps in Original Medicare but do not expand covered services.
If you experience unusual skin reactions—such as sudden widespread pustules after starting a new medication—it's important to seek medical attention, as this could indicate a serious drug reaction like Acute Generalized Exanthematous Pustulosis (AGEP), which requires immediate evaluation and treatment.
Always speak to a doctor about any serious or life-threatening conditions or before starting new treatments. A healthcare professional can help you weigh risks, benefits, and costs to determine if PRP is right for you as a Medicare patient.
(References)
* Han, J. Y., Li, M. P., Li, X. D., Zhang, B. Q., & Wu, F. Y. (2020). Efficacy of platelet-rich plasma in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. *Journal of Orthopaedic Surgery and Research*, *15*(1), 324. https://pubmed.ncbi.nlm.nih.gov/32709124/
* Carter, M. J., Fylling, C. P., & Parnell, J. N. (2020). Platelet-Rich Plasma for the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Clinical Studies. *Plastic and Reconstructive Surgery*, *145*(3), 857e-868e. https://pubmed.ncbi.nlm.nih.gov/32097316/
* Smith, N. P., Smith, N. R., & Soni, P. (2020). Platelet-Rich Plasma for Musculoskeletal Injuries: The Current Landscape in Regulation, Evidence, and Clinical Practice. *Orthopaedic Journal of Sports Medicine*, *8*(12), 2325967120970631. https://pubmed.ncbi.nlm.nih.gov/33364402/
* Ricks, M., & Darr, J. (2018). Reimbursement for Regenerative Medicine: An Evolving Landscape. *Cell Stem Cell*, *23*(1), 11-14. https://pubmed.ncbi.nlm.nih.gov/29979929/
* Mautner, K., et al. (2019). Platelet-Rich Plasma in Musculoskeletal Applications: A Review of Current Evidence and Recommendations for Clinical Practice. *Current Sports Medicine Reports*, *18*(4), 118-124. https://pubmed.ncbi.nlm.nih.gov/30946263/
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