Published on: 4/28/2025
A needle pricking sensation on your skin can be caused by irritated or damaged nerves, often due to nerve injury, chemical influences, or neuropathic issues.
When you feel a painful needle-like prick on your skin, it’s often a sign that your nerves are sending abnormal signals. This sensation is typically linked to neuropathic pain. For example, physical injury, pressure, or repetitive strain can irritate nerves such as in median nerve injuries, causing this kind of sharp, pricking feeling. Certain chemicals, e.g. alcohol, or hydroxy-alpha-sanshool—a compound known to affect nerve endings—can also trigger tingling or pricking sensations on the skin. When nerves are injured or become hyperactive, they may send mixed signals to the brain, resulting in the painful, needle pricking feeling. Other conditions affecting peripheral nerves can disturb the normal way your nerves send and interpret signals, leading to discomfort on the skin surface. To manage this sensation, it is important to identify the underlying cause. Treatment may include medications that target nerve pain, physical therapy to reduce nerve compression, or changes in your activities to prevent further damage. If the sensation persists or worsens, discussing it with a healthcare provider is important for proper evaluation and guidance.
(References)
Lennertz RC, Tsunozaki M, Bautista DM, Stucky CL. Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool. J Neurosci. 2010 Mar 24;30(12):4353-61. doi: 10.1523/JNEUROSCI.4666-09.2010. PMID: 20335471; PMCID: PMC2852189.
Dydyk AM, Negrete G, Sarwan G, et al. Median Nerve Injury. [Updated 2023 Jun 4]. In: StatPearls [Internet].
Stucky CL, Mikesell AR. Cutaneous pain in disorders affecting peripheral nerves. Neurosci Lett. 2021 Nov 20;765:136233. doi: 10.1016/j.neulet.2021.136233. Epub 2021 Oct 1. PMID: 34506882; PMCID: PMC8579816.
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