Published on: 4/28/2025
A prickly feeling all over your body can come from problems with your nerves, which might be caused by conditions like neuropathy, diabetes, kidney issues, vitamin deficiencies, chemical exposure, or problems with small nerve fibers.
When you feel a prickly sensation all over your body, it often means that your nerves are sending mixed signals. This type of feeling can be due to a condition called neuropathy, where the nerves are not working as they should. For example, if your kidneys are not removing the toxins from your blood efficiently (known as uremic neuropathy), waste can build up and irritate your nerves. Sometimes, a condition that affects the small nerve fibers, which help you feel touch and temperature, can cause a similar prickly or tingling sensation. This is sometimes seen in a group of symptoms called neurocutaneous dysesthesias that affect both the skin and nerves. In some cases, the problem might be short term and respond well to treatments like steroids if it is an acute small-fiber sensory neuropathy. If you experience a prickly feeling that worries you or does not go away, it is important to talk to a doctor. They can examine you, run tests, and help find out what might be causing your symptoms.
(References)
Shumway NK, Cole E, Fernandez KH. Neurocutaneous disease: Neurocutaneous dysesthesias. J Am Acad Dermatol. 2016 Feb;74(2):215-28; quiz 229-30. doi: 10.1016/j.jaad.2015.04.059. PMID: 26775772.
Krishnan AV, Kiernan MC. Uremic neuropathy: clinical features and new pathophysiological insights. Muscle Nerve. 2007 Mar;35(3):273-90. doi: 10.1002/mus.20713. PMID: 17195171.
Dabby R, Gilad R, Sadeh M, Lampl Y, Watemberg N. Acute steroid responsive small-fiber sensory neuropathy: a new entity? J Peripher Nerv Syst. 2006 Mar;11(1):47-52. doi: 10.1111/j.1085-9489.2006.00062.x. PMID: 16519781.
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