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Published on: 2/28/2026
Septic shock is a life-threatening emergency where an infection triggers an overwhelming immune response that crashes blood pressure, starving organs of oxygen and causing failure; recognize red flags like confusion, rapid breathing, very low blood pressure, little urine, cold clammy skin, or severe shortness of breath, and call emergency services immediately because early IV fluids, antibiotics, vasopressors, and oxygen can save lives.
There are several factors to consider that can change your next steps, including the infection sources, who is at higher risk, how doctors diagnose it, and what recovery may involve; see below for complete details and urgent actions to take.
Septic shock is a life-threatening medical emergency. It happens when an infection spreads through the body and triggers an extreme immune response that leads to dangerously low blood pressure and organ failure.
This is not a condition to "wait and see." But understanding what septic shock is, how it develops, and what to do can help you act quickly and confidently if needed.
If you're concerned about symptoms, you can use Ubie's free AI-powered Sepsis symptom checker to quickly assess your risk level and get personalized guidance on what to do next.
Septic shock is the most severe stage of sepsis, a condition that occurs when your body's response to infection becomes overwhelming and harmful.
Here's how it typically progresses:
Septic shock requires immediate hospital treatment, often in an intensive care unit (ICU).
Organ failure in septic shock is not caused directly by the infection alone. It happens because of a chain reaction inside the body.
When your body detects infection, it releases chemicals to fight it. In septic shock, this immune response becomes excessive and spreads throughout the bloodstream.
This causes:
Inflammation causes blood vessels to widen and become leaky. Fluid moves out of the bloodstream and into tissues.
As a result:
Organs need constant oxygen and nutrients. When blood pressure falls too low:
Without rapid treatment, this can progress to multiple organ failure.
Any infection can potentially lead to septic shock, but the most common sources include:
Certain people are at higher risk:
Symptoms can develop quickly and may appear mild at first. Early recognition saves lives.
If someone shows these symptoms, call emergency services immediately. Septic shock is a medical emergency.
Doctors use a combination of:
Diagnosis is based on:
There is no single test for septic shock. It's diagnosed based on clinical findings and rapid assessment.
Treatment must begin immediately, often within the first hour of recognition.
Large amounts of fluids are given quickly to:
Broad-spectrum antibiotics are started right away, even before the exact infection source is identified. Delays increase risk.
If blood pressure remains low after fluids:
If breathing becomes difficult:
Depending on which organs are affected:
Yes — many people survive septic shock, especially with early treatment.
However:
Early recognition and fast treatment dramatically improve survival rates.
Do not delay if you or someone else has:
If something feels seriously wrong, trust your instincts.
While not all cases are preventable, you can lower risk by:
If you're unsure whether symptoms could be serious, check your symptoms using Ubie's free Sepsis checker to better understand what action you should take.
Septic shock is a severe and life-threatening complication of infection. It occurs when the body's response to infection causes widespread inflammation, low blood pressure, and organ failure.
Key facts to remember:
If you suspect septic shock, do not wait. Call emergency services right away.
For anything that may be life-threatening or serious, speak to a doctor immediately. Quick action can make all the difference.
(References)
* Singer M. Septic Shock. N Engl J Med. 2021 Jul 1;385(1):70-83. doi: 10.1056/NEJMra2026107. PMID: 34185186.
* Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign International Guidelines for Management of Sepsis and Septic Shock 2021. Intensive Care Med. 2021 Oct;47(10):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2. PMID: 34509825.
* Puthucheary Z, Annane D. Septic shock. Best Pract Res Clin Anaesthesiol. 2023 Mar;37(1):15-28. doi: 10.1016/j.bpa.2022.12.001. PMID: 36737083.
* Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Opal SM, Rubertsson L, van der Poll D, Vincent JL, Zimmerman GA. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. Erratum in: JAMA. 2016 May 24-31;315(20):2227. PMID: 26903338.
* Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and Septic Shock. Lancet. 2018 Mar 24;391(10134):1854-1864. doi: 10.1016/S0140-6736(18)30225-7. PMID: 29503116.
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