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Published on: 2/23/2026
Sudden, sharp pain in the upper right abdomen that may radiate to the back or shoulder often comes from gallstones blocking bile flow, causing biliary colic and sometimes serious complications like gallbladder inflammation, bile duct blockage, or pancreatitis. Seek urgent care for severe pain lasting hours, fever, jaundice, or persistent vomiting; diagnosis is usually by ultrasound and treatment may include gallbladder removal or ERCP for a blocked duct. There are several factors to consider that can change your next steps, including risk factors, when watchful waiting is reasonable, and key warning signs; see below for complete details.
Sharp abdominal pain can be alarming—especially when it comes on suddenly and feels intense. One common cause of this type of pain is gallstones. While many people with gallstones never have symptoms, others experience severe discomfort that can't be ignored.
Understanding why gallstones hurt, what symptoms to watch for, and what to do next can help you respond quickly and appropriately.
Gallstones are hardened deposits that form inside the gallbladder, a small organ located under the liver on the right side of your abdomen. The gallbladder stores bile, a digestive fluid that helps break down fats.
Gallstones can form when:
Gallstones can range in size from a grain of sand to a golf ball. Some people have just one. Others may have several.
Importantly, many people with gallstones never experience symptoms. These are called "silent gallstones." Problems start when a stone blocks a bile duct.
Pain from gallstones happens when a stone blocks the normal flow of bile. This blockage causes pressure to build up in the gallbladder, leading to inflammation and intense discomfort.
The most common painful condition related to gallstones is called biliary colic.
The pain can be sharp, cramping, or steady and severe. It may be strong enough to interfere with normal activities.
If the blockage persists, more serious conditions can develop.
Gallstones don't always stop at causing temporary pain. In some cases, complications can develop, including:
This occurs when a stone remains lodged in the gallbladder outlet.
Symptoms may include:
This condition requires medical attention.
If a gallstone moves into the main bile duct, it can block bile flow from the liver.
Signs may include:
A gallstone can block the pancreatic duct, leading to inflammation of the pancreas.
Symptoms may include:
Pancreatitis can be serious and requires immediate medical care.
People describe gallstone pain in different ways, but common descriptions include:
Unlike indigestion, gallstone pain does not usually improve with antacids or a bowel movement. It often peaks quickly and can be severe.
If you're experiencing sharp upper abdominal discomfort and want to better understand what might be causing it, you can use a free abdominal pain symptom checker to explore possible causes and determine whether you should seek medical care right away.
Gallstones are common. Certain factors increase the risk:
That said, anyone can develop gallstones—even without clear risk factors.
If your doctor suspects gallstones, they will:
The most common test is an abdominal ultrasound. It is painless and highly effective at detecting gallstones.
In some cases, additional imaging such as CT scans or MRIs may be used.
Blood tests may also be ordered to check for infection, inflammation, or bile duct blockage.
Treatment depends on whether your gallstones are causing symptoms.
No treatment may be needed. Many people live their entire lives without symptoms.
Treatment typically involves:
This is the most common and effective treatment.
Once the gallbladder is removed, gallstones cannot recur.
In rare cases, medications may be used to dissolve cholesterol gallstones. However:
If a gallstone is stuck in a bile duct, a procedure called ERCP may be used to remove it without surgery.
You should seek urgent medical attention if you experience:
These could signal serious complications that require prompt treatment.
Do not ignore intense or worsening pain.
You cannot completely eliminate the risk of gallstones, but you can lower it by:
Small, sustainable lifestyle changes are more protective than extreme dieting.
No. Many conditions can cause sharp abdominal pain, including:
Because abdominal pain has many possible causes, getting a proper medical evaluation is essential.
If you are unsure what your symptoms mean, starting with a structured assessment like a symptom check for Abdominal pain can provide guidance—but it should not replace professional medical care.
Gallstones are common, and many people never know they have them. But when gallstones block bile flow, they can cause sharp, intense abdominal pain that should not be ignored.
Most cases are treatable, and gallbladder removal is a safe and widely performed procedure. Serious complications are possible—but they are manageable when treated promptly.
If you experience:
You should speak to a doctor immediately.
Even if symptoms are mild, it's wise to schedule a medical evaluation to confirm the cause. Abdominal pain can sometimes signal life-threatening conditions, and early diagnosis makes a difference.
When in doubt, listen to your body—and speak to a doctor about anything that could be serious or life threatening.
(References)
* Zhang Y, Li Y, Wu Q, Wang D, Wang J. Pathophysiology of gallstone disease. Ann Transl Med. 2017 Dec;5(24):485. PMID: 29330137.
* Indar AA, Beckingham IJ. Acute cholecystitis: current concepts in pathogenesis, diagnosis, and management. World J Gastroenterol. 2014 Dec 14;20(46):17787-803. PMID: 25516760.
* Shaffer EA. Gallstone Disease: Pathogenesis, Diagnosis, and Management. Gastroenterology. 2019 Jul;157(1):50-66.e2. PMID: 30878586.
* Yokoe M, Hata J, Takada T, Strasberg SM, Asbun HJ, Wakabayashi G, Cosgrove D, Liu Y, Jiang W, Parks RW, Gouma DJ, Morton JM, Goor HV, Jagannath P, Endo I, Okamoto K, Tabata H, Wada K, Hwang TL, Chen MF, Ker CG, Chen XP, Han HS, Deziel DJ, Kim MH, Quiatao LA, Dong J, Su CH, Singh H, Chen H, Tsuyuguchi T, Kadoya M, Kitamura K, Miyazaki M, Yamamoto M. Tokyo Guidelines 2018: updated clinical management of acute cholecystitis, acute cholangitis. J Hepatobiliary Pancreat Sci. 2018 Jan;25(1):1-77. PMID: 29043440.
* Neri V, Sbrighi S, Binda B, Sesti F, Balducci G. Biliary colic: current knowledge and new perspectives. Minerva Med. 2016 Apr;107(2):128-36. PMID: 27077977.
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