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Published on: 2/25/2026
Most skin lesions are harmless, but some are dangerous; key warning signs include the ABCDEs of melanoma, a spot that bleeds or will not heal, rapid growth, pain, crusting or oozing, and a persistent firm shiny bump or scaly patch.
Next steps: do a full skin self-check and practice sun protection, and see a clinician for any new, changing, or symptomatic lesion since diagnosis may require dermatoscopy and a biopsy, with treatments ranging from topical medicines and cryotherapy to surgical removal. There are several factors to consider and urgent red flags like rapid changes, infection signs, swollen lymph nodes, or unexplained weight loss warrant immediate care; see the complete details below.
Noticing a new spot on your skin can be unsettling. Is it just a harmless blemish—or something more serious? The truth is, skin lesions are extremely common, and most are not dangerous. But some do require medical attention. Understanding what skin lesions are, why they appear, and when to act can help you make calm, informed decisions about your health.
A skin lesion is any area of skin that looks or feels different from the surrounding skin. It may be:
Skin lesions can appear anywhere on the body. Some are present at birth (like certain birthmarks), while others develop over time due to sun exposure, aging, infections, allergies, or other health conditions.
Most skin lesions are benign (non-cancerous). Here are some of the most common types:
While many skin lesions are harmless, some can signal skin cancer or other serious conditions. The key is recognizing warning signs.
If you notice a mole or pigmented lesion changing, look for:
Any of these changes warrant prompt medical evaluation.
Seek medical advice if a skin lesion:
These could indicate types of skin cancer such as basal cell carcinoma, squamous cell carcinoma, or melanoma.
There are many causes of skin lesions. Understanding the source can help guide next steps.
Ultraviolet (UV) radiation damages skin cells. Over time, this increases the risk of precancerous and cancerous skin lesions.
Bacterial, viral, or fungal infections can cause lesions like warts, cold sores, or ringworm.
Contact dermatitis from soaps, metals, or plants can lead to itchy rashes.
Conditions like psoriasis or lupus can produce distinct skin lesions.
As skin ages, new spots and growths naturally develop.
Family history can increase your risk of certain skin cancers or unusual moles.
If you visit a healthcare professional about a concerning spot, they may:
A biopsy is the only way to definitively diagnose skin cancer. While the word sounds intimidating, it is usually a quick in-office procedure with minimal discomfort.
It's important not to panic. The majority of skin lesions are benign. However, ignoring persistent or changing lesions is not wise either.
A good rule of thumb:
Early detection makes a major difference, especially for melanoma. When caught early, treatment outcomes are significantly better.
If you're unsure about a spot, start with these practical steps:
If you've noticed unusual changes in your skin and want to understand whether they need medical attention, try using a free abnormal skin symptom checker to get personalized insights about your symptoms and learn what steps to take next.
Some symptoms require prompt medical attention. Speak to a doctor right away if a skin lesion:
If there is any concern that a lesion could be cancerous or life-threatening, do not delay care. Early evaluation can be lifesaving.
Treatment depends on the diagnosis. Options may include:
For skin cancer, treatment may involve surgical removal, specialized procedures, or referral to a dermatologist or oncologist.
Most skin lesions are harmless. But some can signal more serious conditions, including skin cancer. The key is awareness—not fear.
Pay attention to:
If something doesn't seem right, trust your instincts and speak to a doctor. It is always better to have a professional evaluation than to ignore a potentially serious issue.
Your skin is your body's largest organ. Taking a few minutes to check it regularly—and acting promptly when something changes—can protect your health for years to come.
(References)
* Sotoodian B, Hsieh YW. Cutaneous Lesions: Differential Diagnosis and Approach. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK589693/
* Oakley A, Patel D, Lim A. Diagnosis of common skin diseases for primary care practitioners. BMJ. 2023 Feb 15;380:e072935. doi: 10.1136/bmj-2022-072935. PMID: 36792196.
* US Preventive Services Task Force. Skin Cancer Screening: US Preventive Services Task Force Recommendation Statement. JAMA. 2023 May 23;329(20):1776-1783. doi: 10.1001/jama.2023.6826. PMID: 37219213.
* Abbasi NR, Kim CS, Salama AD. The ABCDs of melanoma detection. BMJ. 2023 Feb 15;380:e072898. doi: 10.1136/bmj-2022-072898. PMID: 36792197.
* Wang Q, Yan X, Yang Z, Peng Z, Zheng R. Classification of skin lesions: A review. Comput Biol Med. 2023 May;158:106849. doi: 10.1016/j.compbiomed.2023.106849. Epub 2023 Mar 15. PMID: 36934440.
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