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Published on: 4/9/2026
Upper left abdominal pain, fullness, or pressure can be caused by a swollen spleen from infections, liver disease, blood cancers or blood disorders, and autoimmune inflammation; sudden severe pain, pain to the left shoulder, faintness, or signs of internal bleeding are emergencies.
Medically approved next steps are to track symptoms, avoid contact sports and heavy lifting, and seek prompt medical evaluation so the underlying cause can be treated and the spleen often returns to normal. There are several factors to consider; see the complete guidance below for specific red flags, diagnosis, treatment options, and prevention tips that can affect your next steps.
If you're feeling pain or pressure in the upper left side of your abdomen, your spleen could be involved. While spleen problems are not as common as other digestive issues, a swollen spleen (called splenomegaly) can signal an underlying health condition that deserves attention.
This guide explains what the spleen does, why spleen pain happens, what causes spleen swelling, and what medically approved next steps you should take.
The spleen is a fist-sized organ located in the upper left side of your abdomen, just under your rib cage and next to your stomach.
It plays several important roles:
You can live without a spleen, but it plays a valuable role in keeping your body healthy.
Spleen pain is usually felt:
It may feel like:
In some cases, there may be no pain at all, and a swollen spleen is only discovered during a physical exam or imaging test.
A swollen spleen (splenomegaly) is not a disease itself. It is usually a sign of another medical condition.
When the spleen becomes enlarged, it may:
A severely enlarged spleen can become fragile, which is why unexplained upper-left abdominal pain should never be ignored.
There are several medically recognized causes of spleen enlargement. These include:
Infections are one of the most common reasons the spleen swells.
Infections cause the immune system to ramp up activity, which can enlarge the spleen.
Conditions affecting the liver can impact blood flow through the spleen.
When blood flow backs up, the spleen can enlarge.
Certain blood-related conditions can cause spleen swelling:
These conditions may also cause fatigue, easy bruising, or frequent infections.
Chronic inflammatory and autoimmune conditions can affect the spleen:
Some cancers, particularly blood cancers, may enlarge the spleen. This is why persistent spleen swelling always requires medical evaluation.
While many causes of spleen swelling are treatable, there are situations where urgent care is necessary.
Seek emergency medical attention if you experience:
These symptoms could indicate a ruptured spleen, which is life-threatening and requires immediate care.
If you visit a healthcare provider for suspected spleen pain, they may:
Early evaluation helps identify the root cause and guide treatment.
If you suspect spleen pain or swelling, here are safe and appropriate steps to take:
Track:
This information helps your doctor make an accurate diagnosis.
If your spleen is enlarged or suspected to be enlarged:
An enlarged spleen is more vulnerable to rupture.
Even mild but persistent upper-left abdominal pain should be evaluated.
If you're experiencing discomfort and want to understand what might be causing it, you can use a free abdominal pain symptom checker to help identify potential causes and determine how urgently you should seek care.
However, this does not replace professional medical care.
Treatment depends entirely on the root problem:
In rare cases, if the spleen becomes dangerously enlarged or repeatedly ruptures, surgical removal (splenectomy) may be necessary.
Yes — in many cases.
If the underlying condition is treated effectively:
For example, spleen enlargement from a viral infection like mononucleosis often improves over several weeks with rest and recovery.
You cannot prevent all causes of spleen swelling, but you can reduce risk by:
The spleen is an important immune and blood-filtering organ. Pain or swelling in this area is usually a sign of another condition, such as infection, liver disease, or a blood disorder.
Most causes are treatable — but they require proper diagnosis.
Do not ignore:
If you are experiencing symptoms that could indicate a serious or life-threatening condition — especially severe pain or signs of internal bleeding — seek immediate emergency care.
For non-emergency symptoms, consider checking your abdominal pain symptoms to better understand what might be happening and then speak to a doctor promptly to ensure proper evaluation and treatment.
When it comes to your spleen, early action is the safest approach.
(References)
* Uthman OA, Al-Sultan M, O'Mahony L, Al-Ani M, O'Brien F, Al-Hilli S, D'Cruz DP. Splenomegaly: Clinical significance and approach to diagnosis. World J Hepatol. 2021 Apr 27;13(4):393-404. doi: 10.4254/wjh.v13.i4.393. PMID: 33995819; PMCID: PMC8109919.
* Del Bello B, Sguanci M, Montano N. Splenomegaly in adults: a diagnostic approach based on the underlying disease. Intern Emerg Med. 2023 Jul;18(5):1373-1384. doi: 10.1007/s11739-023-03310-0. Epub 2023 Jun 2. PMID: 37266787.
* Al-Ani M, Uthman OA, Al-Hilli S, Al-Sultan M, O'Brien F, O'Mahony L, D'Cruz DP. Approach to the Adult Patient With Splenomegaly. J Clin Med. 2022 Dec 17;11(24):7463. doi: 10.3390/jcm11247463. PMID: 36556108; PMCID: PMC9782552.
* Mebius RE, Schoonderwoerd A. The spleen: anatomy, physiology and clinical considerations. Immunol Rev. 2023 May;314(1):64-77. doi: 10.1111/imr.13175. PMID: 37171410.
* Chapman SE, Clark DJ, King JB. Splenomegaly: causes, diagnosis, and management. Br J Hosp Med (Lond). 2011 May;72(5):260-5. doi: 10.12968/hmed.2011.72.5.260. PMID: 21629166.
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