Ulcerative Colitis Flare? Why Your Colon Is Inflamed & Medical Next Steps

If you're experiencing an ulcerative colitis flare, it can feel frustrating, painful, and unpredictable. Symptoms like diarrhea, abdominal cramping, and urgency can disrupt daily life. Understanding why your colon is inflamed—and what to do next—can help you regain control and reduce complications.

This guide explains what happens during a flare, what may trigger it, and the medical steps that matter most.

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What Is Ulcerative Colitis?

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the lining of the large intestine (colon) and rectum.

Unlike temporary digestive infections, ulcerative colitis is a long-term autoimmune condition. That means your immune system mistakenly attacks the lining of your colon, leading to inflammation.

Over time, ulcerative colitis typically cycles between:

• Remission – Few or no symptoms
• Flare – Active inflammation and worsening symptoms

A flare means the inflammation is active again.

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What Happens During an Ulcerative Colitis Flare?

During a flare, your immune system becomes overactive in the colon. This causes:

• Swelling of the colon lining
• Formation of small ulcers
• Bleeding
• Increased mucus production
• Reduced ability to absorb water

As a result, common symptoms include:

• Frequent diarrhea (often with blood or mucus)
• Abdominal pain or cramping
• Urgency to have a bowel movement
• Feeling like you still need to go after using the bathroom
• Fatigue
• Low-grade fever (sometimes)

In more severe cases:

• Significant blood loss
• Dehydration
• Weight loss
• Severe abdominal pain
• Rapid heart rate

If symptoms are severe, this can become a medical emergency. More on that below.

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Why Is Your Colon Inflamed?

The exact cause of ulcerative colitis isn't fully understood, but experts believe it results from a combination of:

1. Immune System Dysfunction

Your immune system mistakenly attacks the cells lining your colon. Instead of protecting you, it creates chronic inflammation.

2. Genetic Factors

If you have a family history of inflammatory bowel disease, your risk is higher.

3. Environmental Triggers

While these don't cause ulcerative colitis, they can contribute to flares:

• Infections
• Certain medications (like NSAIDs)
• Stress
• Smoking cessation (in some cases)
• Changes in gut bacteria

4. Medication Changes

Stopping maintenance medication—even if you feel well—is one of the most common causes of a flare.

Ulcerative colitis requires long-term management, even during remission.

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How Serious Is a Flare?

Mild to moderate flares are common and treatable. However, severe flares can lead to complications, including:

• Severe dehydration
• Significant blood loss
• Anemia
• Toxic megacolon (a rare but life-threatening swelling of the colon)
• Perforation of the colon

You should seek urgent medical care if you experience:

• Severe abdominal pain
• High fever
• Persistent vomiting
• Heavy rectal bleeding
• Signs of dehydration (dizziness, very little urination)
• More than 6–10 bloody stools per day

Do not ignore these symptoms. Prompt treatment can prevent serious outcomes.

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How Doctors Evaluate a Flare

If you suspect an ulcerative colitis flare, your doctor may recommend:

Medical History and Symptom Review

They'll ask about:

• Frequency of bowel movements
• Presence of blood
• Pain severity
• Medication adherence

If you're experiencing symptoms and want to understand them better before your appointment, you can use a free AI-powered tool to check your Ulcerative Colitis symptoms and help organize what you're experiencing.

Lab Tests

• Blood tests (to check for anemia and inflammation)
• Stool tests (to rule out infections like C. diff)

Imaging or Endoscopy

• Colonoscopy or flexible sigmoidoscopy
• CT scan (if complications are suspected)

Testing helps determine whether symptoms are truly a flare or caused by infection.

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Medical Treatment Options During a Flare

Treatment depends on severity.

Mild to Moderate Flare

Doctors may adjust or add:

• 5-ASA medications (such as mesalamine)
• Rectal therapies (suppositories or enemas)
• Short-term corticosteroids

These reduce inflammation directly in the colon.

Moderate to Severe Flare

Treatment may include:

• Oral or IV corticosteroids
• Biologic medications (such as anti-TNF drugs)
• JAK inhibitors
• Hospitalization (if symptoms are severe)

In some cases, IV fluids and close monitoring are required.

When Surgery Is Needed

If medications fail or complications develop, surgery to remove the colon (colectomy) may be recommended. While this sounds drastic, surgery can be life-saving and eliminates ulcerative colitis because the diseased colon is removed.

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What You Can Do During a Flare

While medication is essential, supportive care matters too.

Stay Hydrated

Diarrhea can cause dehydration quickly. Drink fluids regularly.

Eat Gently

During a flare, you may tolerate:

• Low-fiber foods
• Soft foods
• Small, frequent meals

Avoid foods that worsen symptoms for you personally.

Avoid NSAIDs

Pain relievers like ibuprofen may worsen inflammation.

Rest

Fatigue is common during a flare. Your body needs energy to heal.

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Can Stress Cause a Flare?

Stress does not cause ulcerative colitis, but it can worsen symptoms and may trigger flares in some people. Managing stress through:

• Regular sleep
• Gentle exercise
• Mindfulness or breathing exercises
• Counseling

can help support overall disease control.

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Preventing Future Flares

The most important way to prevent flares is consistent medical treatment, even when you feel well.

Key strategies include:

• Taking maintenance medications as prescribed
• Attending regular follow-ups
• Monitoring symptoms early
• Avoiding known triggers
• Getting recommended vaccines

Ulcerative colitis is a chronic condition. Long-term partnership with your doctor is essential.

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When to Speak to a Doctor Immediately

Do not wait if you experience:

• Severe abdominal pain
• Persistent high fever
• Heavy rectal bleeding
• Signs of shock (confusion, rapid heartbeat, weakness)
• Inability to keep fluids down

These symptoms can indicate serious complications and may be life-threatening.

Even milder symptoms that persist for several days should prompt a call to your gastroenterologist. Early treatment often prevents hospitalization.

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The Bottom Line

An ulcerative colitis flare happens when inflammation in your colon becomes active again. This inflammation is driven by immune system dysfunction and can be triggered by infections, medication changes, or other stressors.

The good news: most flares are manageable with prompt medical treatment. The key is recognizing symptoms early and working closely with your doctor.

If you're noticing new or worsening digestive symptoms and want to better understand whether they align with Ulcerative Colitis, an AI-powered symptom checker can help guide your next steps before seeing a healthcare provider.

Ulcerative colitis is serious—but it is treatable. With proper care, many people achieve long periods of remission and maintain a full, active life.

If you think your symptoms could be severe or life-threatening, speak to a doctor immediately or seek emergency medical care.