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Published on: 1/27/2026

can ulcerative colitis cause weight gain?

Yes, ulcerative colitis can cause weight gain. There are several factors to consider; common drivers include corticosteroids that boost appetite and cause fluid retention, increased intake during remission, reduced activity, emotional eating, and improved absorption when inflammation is controlled. Weight gain can be healthy if you were underweight, but it is concerning if rapid or paired with swelling, shortness of breath, or high blood sugar symptoms; guidance on when to seek care and how to manage weight safely is outlined below.

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Explanation

Can Ulcerative Colitis Cause Weight Gain?

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects the lining of the large intestine (colon) and rectum. Many people associate UC with weight loss, diarrhea, and abdominal pain—especially during flares. However, a common and reasonable question is: can ulcerative colitis cause weight gain?

The short answer is yes, it can, but the reasons are often indirect and vary from person to person. Below is a clear, balanced explanation based on well-established medical knowledge and clinical guidelines, using plain language and practical examples.


Understanding Weight Changes in Ulcerative Colitis

Weight changes in ulcerative colitis are influenced by several factors, including:

  • Disease activity (flare vs. remission)
  • Medications
  • Appetite and diet changes
  • Physical activity levels
  • Mental and emotional health

While active inflammation often leads to weight loss, weight gain is more likely during remission or as a side effect of treatment.


How Ulcerative Colitis Can Lead to Weight Gain

1. Steroid Medications Are a Common Cause

One of the most common reasons for weight gain in ulcerative colitis is the use of corticosteroids (such as prednisone). These medications are effective at reducing inflammation but can have noticeable side effects.

Steroids may cause:

  • Increased appetite
  • Fluid retention (water weight)
  • Fat redistribution (often in the face, neck, or abdomen)
  • Changes in how the body processes sugar and fat

This type of weight gain can happen even if your eating habits don’t change much. It is usually more noticeable with higher doses or longer treatment courses.

Important note: Steroids are often intended for short-term use, and weight changes may improve once they are tapered or stopped under medical supervision.


2. Eating More During Remission

When ulcerative colitis symptoms improve, appetite often returns. This is a positive sign, but it can also lead to weight gain.

Common scenarios include:

  • Eating larger portions after long periods of restricted intake
  • Enjoying “safe foods” that are high in calories but low in fiber
  • Feeling relieved and less cautious about food choices

For some people, this leads to healthy weight restoration. For others, it may result in unintended weight gain, especially if calorie intake exceeds energy needs.


3. Reduced Physical Activity

During flares, fatigue, pain, and urgency can significantly limit movement. Over time, this can lead to:

  • Loss of muscle mass
  • Reduced metabolism
  • Difficulty returning to previous activity levels

Even after symptoms improve, some people remain less active due to fear of triggering symptoms or lingering fatigue. This imbalance between calories consumed and calories burned can contribute to gradual weight gain.


4. Emotional and Stress-Related Eating

Living with ulcerative colitis can be stressful. Stress, anxiety, or low mood may affect eating habits in ways that promote weight gain.

Examples include:

  • Eating for comfort during flares or uncertainty
  • Choosing processed or sugary foods that feel easier to tolerate
  • Irregular eating patterns

These behaviors are understandable and common—but over time, they can influence weight.


5. Improved Nutrient Absorption

When inflammation is controlled, the colon functions better. This can mean:

  • Better absorption of nutrients and calories
  • Less diarrhea and fluid loss
  • More stable digestion

For people who were underweight due to active disease, weight gain can be appropriate and beneficial. The key difference is whether the weight gain supports overall health or begins to cause new concerns.


Is Weight Gain Always a Problem in Ulcerative Colitis?

Not necessarily.

Weight gain may be:

  • Helpful if you were underweight or malnourished
  • Neutral if it stabilizes at a healthy level
  • Concerning if it happens rapidly, feels out of control, or is linked to medication side effects

What matters most is body composition, energy levels, and metabolic health, not just the number on the scale.


When Weight Gain May Signal a Medical Issue

While weight gain itself is not usually dangerous, certain patterns should be discussed with a healthcare professional:

  • Rapid or unexplained weight gain
  • Significant swelling in the legs, face, or abdomen
  • Weight gain alongside shortness of breath or fatigue
  • Signs of steroid-related complications (such as high blood sugar)

These situations deserve medical attention, especially if they develop quickly or feel unusual for you.


Managing Weight Gain with Ulcerative Colitis

Weight management with ulcerative colitis should be gentle, realistic, and medically informed. Extreme diets or aggressive weight loss plans can worsen symptoms.

Helpful strategies often include:

Nutrition Tips

  • Focus on balanced meals with protein, healthy fats, and tolerated carbohydrates
  • Limit highly processed foods when possible
  • Work with a dietitian familiar with ulcerative colitis if available
  • Adjust fiber intake based on symptoms and disease activity

Movement

  • Start with low-impact activities like walking or stretching
  • Increase gradually as energy allows
  • Choose activities that feel safe and sustainable

Medication Review

  • Ask your doctor whether steroid-sparing treatments are appropriate
  • Review all medications that may affect appetite or metabolism

Checking Your Symptoms and Patterns

If you’re unsure whether your weight changes are related to ulcerative colitis, treatment, or something else, it may help to review your symptoms in an organized way.

You might consider doing a free, online symptom check for Ulcerative Colitis to better understand patterns and decide whether follow-up care is needed.

This kind of tool does not replace medical advice, but it can support more informed conversations with your healthcare provider.


Can Weight Gain Be Prevented?

Not always—but it can often be managed.

Prevention focuses on:

  • Using the lowest effective dose of steroids for the shortest time needed
  • Monitoring weight regularly (without obsession)
  • Addressing stress and sleep
  • Seeking early guidance when changes start to feel uncomfortable

Weight changes are part of the broader picture of living with ulcerative colitis, not a personal failure.


The Bottom Line

Ulcerative colitis can cause weight gain, most often due to medications like steroids, improved appetite during remission, reduced activity, and emotional factors. For some people, weight gain is a sign of healing. For others, it may be an unwanted side effect that deserves attention.

What matters most is your overall health, symptom control, and quality of life.

If weight gain feels rapid, distressing, or comes with other symptoms, speak to a doctor. Any signs that could be serious or life-threatening—such as severe swelling, breathing problems, or major changes in blood sugar—should be addressed promptly by a medical professional.

With the right support and individualized care, weight changes related to ulcerative colitis can usually be understood and managed in a safe, realistic way.

(References)

  • * Alkhayyat M, Alshami M, Alqatawnah M, Al-Hammoud R, Mansoor E, Alsuwaidi A, Hammami MB. Weight gain after medical therapy for inflammatory bowel disease. World J Gastroenterol. 2023 Mar 22;29(11):1722-1736. doi: 10.3748/wjg.v29.i11.1722. PMID: 36984813. https://pubmed.ncbi.nlm.nih.gov/36984813/

  • * Koutsochristou V, Kapsoritakis AN, Kapsoritaki E, Sideri S, Dimoulios P, Giannakopoulou D, Dimidis A, Vlachaki M, Giannakidou S, Dounis E, Nakos A, Kountouras J. Changes in body composition in inflammatory bowel disease: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):15-28. doi: 10.17235/reed.2020.7301/2020. PMID: 32808544. https://pubmed.ncbi.nlm.nih.gov/32808544/

  • * Nic Suibhne T, Raftery T, Walsh C, Moran C, Kennedy B, Coffey JC, Cullen G, Walsh P. Obesity in Inflammatory Bowel Disease. J Crohns Colitis. 2020 Feb 28;14(2):247-257. doi: 10.1093/ecco-jcc/jjz154. PMID: 31696225. https://pubmed.ncbi.nlm.nih.gov/31696225/

  • * Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. Weight gain and obesity in patients with inflammatory bowel disease. Curr Gastroenterol Rep. 2016 Nov;18(11):61. doi: 10.1007/s11894-016-0530-5. PMID: 27613589. https://pubmed.ncbi.nlm.nih.gov/27613589/

  • * Sarin M, Long MD, Barnes EL, Kappelman MD, Dulai PS, Martin CF, Shah SA, Siegel CA. Does remission of inflammatory bowel disease lead to weight gain? A cross-sectional analysis from the Crohn's and Colitis Foundation Partners Cohort. Inflamm Bowel Dis. 2023 Oct 1;29(10):1511-1518. doi: 10.1093/ibd/zzad007. PMID: 36625299. https://pubmed.ncbi.nlm.nih.gov/36625299/

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