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Published on: 2/10/2026
For women 65+, vitamin B3 in the niacinamide form helps maintain brain energy and memory, supports nerves, and strengthens aging skin by improving barrier function, hydration, tone, and repair. Many older adults may not get enough due to reduced intake or absorption; about 14 mg/day from food or a low-dose supplement can meet needs, with niacinamide preferred and higher doses only with medical guidance. There are several factors to consider. See below for food sources, signs of deficiency, safety and medication interactions, and when to speak with a doctor to decide on testing or supplementation.
As women age, the body's nutritional needs change. One nutrient that often deserves renewed attention after age 65 is Vitamin B3 (Niacinamide). This form of vitamin B3 plays a quiet but essential role in keeping the brain sharp, the skin resilient, and the body's cells functioning properly. While it doesn't get the same spotlight as vitamin D or calcium, niacinamide is deeply involved in how we think, remember, and age.
Below is a clear, evidence-based look at why Vitamin B3 (Niacinamide) matters for women 65+, how it supports brain and skin health, and what to consider when deciding whether you're getting enough.
Vitamin B3 comes in several forms. The two most common are:
Niacinamide is the form most often used for daily nutrition and skin health because it:
Vitamin B3 (Niacinamide) helps the body make NAD+, a molecule every cell needs to create energy and repair DNA. As we age, NAD+ levels naturally decline, which is one reason this vitamin becomes more important later in life.
Several age-related changes can increase the risk of low vitamin B3 levels:
Women, in particular, may also experience changes in skin integrity and cognitive resilience after menopause, both of which are linked to adequate vitamin B3 status.
The brain uses more energy than any other organ. Vitamin B3 (Niacinamide) helps brain cells:
Low levels may contribute to mental fatigue, slower thinking, or difficulty concentrating.
Research from respected academic and government health institutions has linked adequate vitamin B3 intake to:
While vitamin B3 is not a cure for dementia, it plays a supportive role in keeping brain cells functioning as they should.
Vitamin B3 (Niacinamide) is involved in nerve repair and maintenance. For women 65+, this may help with:
Any new or worsening neurological symptoms should always be discussed with a doctor.
Dermatologists have studied Vitamin B3 (Niacinamide) extensively, especially for aging skin.
Niacinamide works from the inside (nutrition) and the outside (topical creams), which is why it's commonly recommended for mature skin.
Severe deficiency of Vitamin B3 can lead to a condition called pellagra. While uncommon in developed countries, it still occurs, especially in older adults with limited diets or absorption problems.
Classic symptoms include:
If you're experiencing any combination of these symptoms and wonder whether they could be related to Pellagra, a free AI-powered symptom checker can help you understand your risk and determine if you should seek medical evaluation.
General recommendations for older women are about 14 mg per day of vitamin B3 from food and supplements combined. Many women meet this through diet, but not all.
If appetite is low or meals are repetitive, intake may fall short.
A low-dose Vitamin B3 (Niacinamide) supplement may be considered if:
Important points:
Excessive vitamin B3 intake can stress the liver or interact with medications, which is why professional guidance matters.
Vitamin B3 (Niacinamide) is generally safe at recommended levels, but women 65+ should be cautious if they:
Always review supplements with a healthcare provider to avoid unintended interactions.
You should speak to a doctor if you experience:
A doctor can determine whether symptoms are related to Vitamin B3 (Niacinamide) or another underlying condition and can recommend appropriate testing or treatment.
Vitamin B3 (Niacinamide) is a foundational nutrient for healthy aging. For women over 65, it supports:
While many women get enough through food, others may benefit from a closer look at their intake. Paying attention to this often-overlooked vitamin is a practical step toward aging with clarity, comfort, and confidence.
If you have concerns, consider a symptom review, talk openly with your doctor, and make decisions based on credible medical guidance—not guesswork.
(References)
* Park KY, Hwang IS, Kim SM, Park HJ, Han SM, Kim BJ, Kang CN. The Effect of Niacinamide on the Skin and Brain: From Preclinical Evidence to Clinical Implications. Int J Mol Sci. 2023 Sep 26;24(19):14589. doi: 10.3390/ijms241914589. PMID: 37785233; PMCID: PMC10573902.
* Braidy N, Liu Y. Niacin in the treatment of Alzheimer's disease: preclinical and clinical evidence. Curr Alzheimer Res. 2017 Dec 29;15(1):1-10. doi: 10.2174/1567205014666171120124846. PMID: 29283973.
* Gehring W. Niacinamide: A Topical Vitamin with Broad Skin Benefits. J Clin Aesthet Dermatol. 2021 Jun;14(6):6-9. PMID: 34267440; PMCID: PMC8219662.
* Draelos ZD. Topical nicotinamide: a review of its use in cosmetic dermatology. J Clin Aesthet Dermatol. 2013 Dec;6(12):13-7. PMID: 24213791; PMCID: PMC3871992.
* Braidy N, Grant R, Chung RS, Sachdev P, Guillemin GJ. Therapeutic potential of nicotinamide for the treatment of neurodegenerative diseases. Curr Top Med Chem. 2008;8(10):802-8. doi: 10.2174/156802608784961556. PMID: 18598797.
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