Published on: 4/28/2025
Numbness throughout your body may result from nerve damage called peripheral neuropathy, which can occur from conditions like vitamin deficiencies, chemical exposure, kidney problems (uremic neuropathy) or infections such as untreated syphilis (tabes dorsalis). Treatment focuses on finding and managing the underlying cause.
When your body feels numb all over, it means that the nerves, which send messages to your brain, may not be working properly. One common reason is peripheral neuropathy, where nerves are damaged. For instance, if your kidneys are not removing toxins from your blood efficiently, waste can build up and irritate your nerves—a condition known as uremic neuropathy. Another possible cause is an infection like syphilis; if it is not treated, it can lead to a condition called tabes dorsalis, where nerve damage results in numbness. To know what is causing your numbness, a doctor will take a detailed history, perform a physical exam, and might order tests such as blood tests, imaging, or nerve studies. Once the underlying problem is found, treatment can include medications, dietary changes, vitamins, or other therapies designed to treat the root cause. In some cases, physical therapy and supportive care can help manage symptoms. If you experience such numbness, it is important to see a healthcare provider to get a proper diagnosis and take the right steps toward feeling better.
(References)
Beran R. Paraesthesia and peripheral neuropathy. Aust Fam Physician. 2015 Mar;44(3):92-5. PMID: 25770571.
Krishnan AV, Kiernan MC. Uremic neuropathy: clinical features and new pathophysiological insights. Muscle Nerve. 2007 Mar;35(3):273-90. doi: 10.1002/mus.20713. PMID: 17195171.
Bhandari J, Thada PK, Leslie SW, Ratzan RM. Tabes Dorsalis. 2024 Mar 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32491814.
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